Navigation Links
Misread heart muscle gene a new clue to risk of sudden cardiac death
Date:9/16/2013

Scientists have discovered that a drug which increases the risk of sudden cardiac death interacts with mistranslated protein-coding genes present in heart muscle.

The cardiac drug flecainide was developed to prevent and treat serious arrhythmias in the ventricles - the main pumps of the heart. These cause very rapid heart rates which can be lethal if unchecked. However in clinical trials, flecainide, and its sister molecule encainide, were reported to more than double the risk of sudden cardiac death.

Joint work by researchers in the Department of Chemistry and Warwick Medical School at the University of Warwick, and at the SEEK drug discovery group through subsidiary Tangent Reprofiling Limited, is now allowing insight into how cardiac death risk might be increased by these drugs. The method involves persuading viruses to provide a read-out on their surface of proteins related to human heart disease.

Genes that code for proteins, including those from the heart, may be read differently to normal - by starting at a different "letter" in the genetic code - these are called alternative reading frame (ARF) proteins, a bit like a very simple old cipher.

In experiments just published in the Royal Society of Chemistry journal Chemical Communications, the researchers show that flecainide appears to interact with just such an ARF protein, the "normal" version of which is crucial to heart function. This opens the way to further research that may illuminate the positive and negative elements of flecainide's action.

Paul Taylor, Associate Professor in Organic Chemistry, commented "Genes provide the code for cells to make proteins. This new research indicates that flecainide is able to interact with an unexpected translation of the gene coding for the protein - myosin regulatory light chain - a crucial component in the contraction of heart muscle fibres."

Associate Professor of Chemistry Andrew Marsh added "The work is particularly important as it represents a new way to uncover interactions of drugs such as flecainide with ARF proteins. The fuller biomedical significance of these unusual, 'mistranslated' proteins is only just becoming recognised."

Dr Suzanne Dilly, Head of Chemical Biology at SEEK, said " I am delighted to see publication of these important results, which were enabled by sharing of expertise and technology between an excellent academic team and our drug discovery group."

Professor of Clinical Pharmacology and Therapeutics Donald Singer said "Adverse effects of drugs can be very serious. Our work shows an unexpected consequence of adverse effects of a drug: providing clues to new causes for disease and new ideas for treatments. There is clear potential to apply these methods to understanding unexplained risks of other medicines".


'/>"/>

Contact: Paul Taylor
p.c.taylor@warwick.ac.uk
44-024-765-24375
University of Warwick
Source:Eurekalert

Related biology news :

1. Nymi by Bionym launches using your unique heartbeat to unlock your world
2. Your fingers pulse holds the key to your hearts health
3. Youthful stem cells from bone can heal the heart, Temple scientists report
4. Risk factors help predict outcomes for children with rare heart condition
5. Bacterial toxins cause deadly heart disease
6. Visualized heartbeat can trigger out-of-body experience
7. New study redefines how plaques grow in heart disease
8. Calcium linked to increased risk of heart disease and death in patients with kidney disease
9. A heart of gold
10. MS drug shows promise for preventing heart failure
11. Protein targeted for cancer drug development is essential for normal heart function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2016)... 2016 Einzigartige ... und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler Kommunikationsdienste, ... SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie einzusetzen. ... Möglichkeit angeboten, im Rahmen mobiler Apps neben ...
(Date:3/18/2016)... March 18, 2016 --> ... Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter ... companies in the border security market and the continuing migration ... Europe has led visiongain to publish ... success. --> defence & security companies in ...
(Date:3/14/2016)... Florida , March 14, 2016 ... the growing mobile commerce market, announces the airing of a ... channels starting the week of March 21 st .  The ... CNBC, including its popular Squawk on the Street show. ... focused on the growing mobile commerce market, announces the airing ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... Melbourne, FL (PRWEB) , ... May 25, 2016 , ... ... of eight she tore her cruciate ligament in her left knee. Lady’s owner Hannah ... , a central Florida board-certified veterinary surgeon, to repair her cruciate ligament and help ...
(Date:5/24/2016)... ... May 24, 2016 , ... Media ... The new Media Cybernetics corporate branding reflects a results-driven revitalization for a company ... analysis. The re-branding components include a crisp, refreshed logo and a new web ...
(Date:5/23/2016)... May 23, 2016 - Leading CRO,s Use ... - Frontage Implement a Single Platform to Manage End-to-end Operations ... Within the Bioanalytical lab Frontage Laboratories, a full-service contract ... and China , has selected IDBS, ... In addition to serving as the global electronic lab notebook (ELN), ...
(Date:5/20/2016)... , ... May 20, 2016 , ... Kablooe Design, a ... companies, today announced its official 25th anniversary of the business. “We have worked hard ... grateful to our customers for the privilege and honor of serving their product design ...
Breaking Biology Technology: