Navigation Links
Miscarriage and infertility treatment increase pre-eclampsia risk

Repeated miscarriages and hormone treatment for infertility give an increased risk of pre-eclampsia among pregnant women. This comes from a new study from the Norwegian Institute of Public Health. More than 20 000 first-time mothers from the Norwegian Mother and Child Cohort Study (MoBa) were included in the study.

Normal risk

  • First-time mothers who had not miscarried or had problems getting pregnant had a 5.2 % risk of pre-eclampsia.

Risk after miscarriage

  • Women who had three or more miscarriages had a 50 % increased risk of pre-eclampsia compared with women who had not miscarried.
  • Women who had one or two miscarriages are not thought to be at higher risk.
  • Among women who had both miscarriages and treatment for infertility, the risk for pre-eclampsia was 13 %.

Risk after infertility treatment

  • The study also shows that women who had infertility treatment had a 25 % higher risk of pre-eclampsia.
  • Women who became pregnant after hormone treatment to stimulate ovulation had a doubled risk of pre-eclampsia compared to women without treatment.
  • Assisted conception treatment was not linked to an increased risk, even though hormone stimulation is part of the procedure.
  • Different causes of infertility (polycystic ovary syndrome, blocked Fallopian tubes etc.) can probably explain the difference in risk for pre-eclampsia. It is likely that factors in mothers that cause infertility may also give an increased risk of pre-eclampsia.
  • It is less likely that the treatment itself explains the increased risk, even if this cannot be excluded.

The study has been recently published in the British Journal of Obstetrics and Gynaecology, BJOG.

Placenta important for normal development

The causes of pre-eclampsia are unknown, but involve the placenta. The placenta is important for normal development of the pregnancy. Failure in the development and function of the placenta seems to be an important mechanism in the development of pre-eclampsia but no-one knows why. The results from this study show that the protective effect seen after earlier normal pregnancies (births or terminations) is not present among women with repeated miscarriages. The study indicates that common causal factors linked to the placenta's development and function may be present in infertility, repeated miscarriages and pre-eclampsia.

Facts about pre-eclampsia

  • Affects 3-5 % of all pregnant women.
  • Greatest risk among first-time mothers.
  • Appears in second half of pregnancy
  • Recognised by high blood pressure and protein in mother's urine.
  • In mild cases the mother can be unaffected by the condition, but in serious cases, pre-eclampsia can be life-threatening for mother and baby, with organ failure and danger of seizures among mothers.
  • The child risks poor growth and development due to insufficient placenta function.
  • The only treatment is delivery of baby and placenta.
  • Pre-eclampsia is therefore an important cause of premature birth.
  • Among women who have given birth earlier, the risk is approximately halved. The same applies to women who have had earlier terminations. It is unknown why earlier normal pregnancies protect against pre-eclampsia in later pregnancies.


Contact: Media Contact
Norwegian Institute of Public Health

Related biology news :

1. Statins may prevent miscarriages
2. Proteins in sperm unlock understanding of male infertility says new study
3. Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
4. USC researchers explore genetic causes for male infertility
5. UC Davis team refines cancer treatments to reduce potential nerve damage
6. In just 5 years, gene discovery to clinical trial of potential treatment
7. Leeds research points to new therapy for hepatitis C treatment
8. Epilepsy drug shows potential for Alzheimers treatment
9. First trial in patients with a potential treatment of the incurable ALS muscle disease
10. Scientists developing food allergy treatment
11. Inherited genetic cause, possible treatment found for complex lung disorder
Post Your Comments:
(Date:11/4/2015)... , November 4, 2015 ... market report published by Transparency Market Research "Home Security Solutions ... and Forecast 2015 - 2022", the global home security solutions ... bn by 2022. The market is estimated to expand ... from 2015 to 2022. Rising security needs among customers ...
(Date:10/29/2015)... 2015   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that it has ... as one of only three finalists for a ... and Growing" category. The Tekne Awards honor Minnesota ... technology innovation and leadership. iMedNet™ eClinical ...
(Date:10/29/2015)... Va. , Oct. 29, 2015 Daon, ... today that it has released a new version of ... customers in North America have ... IdentityX v4.0 also includes a FIDO UAF certified ... are already preparing to activate FIDO features. These customers ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ - Aeterna Zentaris ... that its business and prospects remain fundamentally strong ... Zoptrex™ (zoptarelin doxorubicin) recently received DSMB recommendation to ... completion following review of the final interim efficacy ... 2 Primary Endpoint in men with heavily pretreated ...
(Date:11/25/2015)... PORTLAND, Oregon , November 25, 2015 /PRNewswire/ ... Deep Market Research Report is a professional and ... Genomics industry.      (Logo: ... basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including ...
(Date:11/24/2015)... ... 24, 2015 , ... The United States Golf Association (USGA) today announced Dr. ... Award. Presented annually since 1961, the USGA Green Section Award recognizes an individual’s distinguished ... , Clarke, of Iselin, N.J., is an extension specialist of turfgrass pathology in ...
(Date:11/24/2015)... VANCOUVER , Nov. 24, 2015 /CNW/ - iCo ... ICOTF), today reported financial results for the quarter ... are expressed in Canadian dollars and presented under ... the United States ," said Andrew ... "These advancements regarding iCo-008 are not only value ...
Breaking Biology Technology: