Navigation Links
Minneapolis Heart Institute selected to participate in Cardiovascular Cell Therapy Research Network
Date:4/4/2012

MINNEAPOLIS, April 2, 2012 The Cardiovascular Cell Therapy Research Network (CCTRN), a nationwide U.S. network funded by the National Institutes of Health's (NIH) National Heart, Lung and Blood Institute (NHLBI) has selected the Minneapolis Heart Institute (MHI) as one of its seven U.S. centers of excellence. The network will receive $63 million from the NIH and NHLBI over the next seven years to help achieve its mission of driving public health advances in cardiovascular cell therapy for the treatment of cardiovascular diseases.

MHI was integral to the success of the first CCTRN initiativea series of clinical studies that took place over five years involving five sites using bone marrow stem cells in patients with heart disease, and in which nearly 50 percent of the patients were enrolled in Minnesota. As principal investigator, Timothy D. Henry, MD, director of research at the MHI, will be responsible for a network of Minnesota hospitals including the Minneapolis Heart Institute at Abbott Northwestern Hospital in Minneapolis, the University of Minnesota in Minneapolis, Mayo Clinic in Rochester, United Hospital in St. Paul, Mercy Hospital in Coon Rapids and Hennepin County Medical Center in Minneapolis.

This extension of CCTRN already has three trials planned, including

  • An allogeneic mesenchymal cell for patients with advanced heart function requiring left ventricular assist device;
  • An enhanced autologous bone marrow cell for patients with claudication (leg pain while walking); and
  • A combination of a bone marrow cell and a novel cardiac derived cell for patients with heart failure.

"These trials will play a key role in identifying the benefits of cell therapy in patients with cardiovascular disease. The Minneapolis Heart Institute at Abbott Northwestern Hospital has been a leader in cardiovascular cell therapy research with more than 300 patients treated for a variety of conditions including acute heart attack, heart failure, ischemic heart disease and peripheral arterial disease," Henry said. "The first CCTRN was highly successful in achieving the NIH's goal of promoting clinical research and has led to the expansion of the network to seven clinical centers for seven years.

Henry noted the remarkable progress in cell therapy over the past several years. Currently, there are several large Phase 3 trials, which if proven efficacious, will lead to cell therapy added to the armamentarium for treating patients with challenging cardiovascular diseases. The CCTRN in particular is critical to provide key insights into the preferred cell, and method of delivery to increase the chance of success.

The CCTRN was created to support the collaboration of physicians, researchers and support staff with expertise in innovative stem cell therapies and experience in leading clinical trials that evaluate leading edge treatments for heart disease.

"Stem cell therapy holds great promise for treating heart disease, and researchers involved in CCTRN are helping determine how these promising therapies might be most beneficial to patients," said Sonia I. Skarlatos, PhD, NHBLI's deputy director of the division of cardiovascular sciences and program director of CCTRN. "This new round of funding is an important step in helping to improve cardiovascular health."

The CCTRN also includes the University of Miami, the University of Florida, Stanford University, Texas Heart Institute, Indiana University and University of Louisville.

Cardiovascular disease remains the leading cause of death in the United States, claiming nearly 900,000 lives each year and more lives than the next five leading causes of death combined. One in three Americans suffer from some form of cardiovascular disease and associated costs are estimated at $432 billion in 2007.


'/>"/>

Contact: Kristin Wincek
kwincek@mhif.org
612-863-0249
Minneapolis Heart Institute Foundation
Source:Eurekalert

Related biology news :

1. Insects scientists to meet in Minneapolis
2. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
3. Cell therapy using patients own bone marrow may present option for heart disease
4. Geological Society of America Cordilleran section meets in the heart of Mexico
5. Heart-powered pacemaker could one day eliminate battery-replacement surgery
6. A change of heart
7. First study to show that bisphenol A exposure increases risk of future onset of heart disease
8. Pancreatic hormone linked with severe heart disease in obese and diabetic patients
9. New ability to regrow blood vessels holds promise for treatment of heart disease
10. Stem cell study in mice offers hope for treating heart attack patients
11. Freeze-dried heart valve scaffolds hold promise for heart valve replacement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... Germany , March 9, 2016 ... country,s government identified that more than 23,000 public service ... or had been receiving their salary unlawfully.    ... African country,s government identified that more than 23,000 public ... name or had been receiving their salary unlawfully.    ...
(Date:3/8/2016)... 2016   Valencell , the leading innovator ... has secured $11M in Series D financing. The ... venture fund being launched by UAE-based financial services ... investors TDF Ventures and WSJ Joshua Fund. Valencell ... triple-digit growth and accelerate its pioneering innovation in ...
(Date:3/3/2016)... March 3, 2016  2016FLEX, organized by FlexTech, ... highlighting advancements in flexible, hybrid and printed electronics. ... attendance - have gathered for short courses, technical ... of electronics. The Flex Conference celebrates its 15 ... companies, R&D organizations, and universities contributing to the ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... The Pittcon Organizing Committee ... Chuck has been a volunteer member of Committee since 1987. Since then, he ... of directors and treasurer and was chairman for both the program and exposition committees. ...
(Date:4/27/2016)... ... 2016 , ... NDA Partners Chairman Carl Peck, MD ... Consultant. Mr. Clark was formerly a Vice President with US Pharmacopeia, where ... monographs based on analytical methods. NDA Partners Expert Consultants are top tier ...
(Date:4/27/2016)... MedDay, a biotechnology company focused on the treatment ... Moukheibir as Chairman of its Board of Directors. ... , who contributed to the rapid development of the Company ... started her career in strategy consulting and investment banking in ... .  She held C-Suite level roles in some of ...
(Date:4/26/2016)... , ... April 26, 2016 , ... ... lithography systems, announces the latest technology innovation for its Volume Pattern Generator (VPG) ... demand for production of advanced photomasks as well as a solution for mid ...
Breaking Biology Technology: