Navigation Links
Mining bacterial genomes reveals valuable 'hidden' drugs
Date:8/1/2010

A new tool to excavate bacterial genomes that potentially hide a rich array of pharmaceutical treasures has led to the discovery of a novel antibiotic. The study, reported in the August issue of Microbiology, could lead to new treatments for serious diseases that are rapidly acquiring multi-drug resistance.

Scientists from the University of Groningen in The Netherlands successfully used a 'genome mining' approach to find and activate a group of genes in the bacterium Streptomyces coelicolor. This resulted in the production of a new antibacterial compound that was effective against several bacterial strains, including Escherichia coli.

Streptomyces is a common soil bacterium that is well-known for its antibiotic-producing capabilities. In 2002, genomic sequencing of one Streptomyces species, S. coelicolor, revealed several groups of genes whose function was unknown. By digging deeper and removing a molecule that specifically inactivates one of the mystery gene groups, known as cpk, the researchers in this study were able to 'awaken' the genes, to find that they produced the new antibiotic, in addition to a bright yellow pigment.

This is the first time a genome mining approach to drug discovery has been successfully used in Streptomyces. "The strategy is a powerful and innovative way of searching for new antibiotic production capabilities in bacteria," said Dr Eriko Takano who led the study. "As bacterial infections previously considered as mild and easily curable are suddenly becoming lethal and completely unresponsive to all existing medication, it is crucial that new antibiotics are discovered at a sufficiently rapid rate," she said.

The same approach for 'awakening' new antibiotic production pathways could also be used to tap other micro-organisms, such as filamentous fungi, for sources of biologically active compounds. Aside from antibiotics, these compounds may include other antimicrobials or antitumour agents. "There are several thousand other uncharacterized groups of genes that have been found recently in microbial genome sequences. This opens up a rich treasure trove of new potential drugs for clinical use," explained Dr Takano.


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert  

Related biology news :

1. Sex on the brain: Doublesex gene key to determining fruit fly gender
2. Plants in mining areas can cure soil affected by contamination in very short time
3. Eminent group of scientists call for moratorium on issuance of mountaintop mining permits
4. Examining diabetes through a new lens
5. New research examining essential drugs, emerging botanicals supported by USP Awards
6. First neuroimaging study examining motor execution in children with autism reveals new insights
7. Study examining role of genetics and environment in type 1 diabetes
8. In the ring: Researchers fighting bacterial infections zero in on microorganisms soft spots
9. Bacterial diversity of Tablas de Daimiel studied for first time
10. New bacterial signaling molecule could lead to improved vaccines
11. Antibacterial silver nanoparticles are a blast
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mining bacterial genomes reveals valuable 'hidden' drugs
(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
(Date:3/24/2017)... , March 24, 2017 The Controller General ... Controller Mr. Abdulla Algeen have received the prestigious international IAIR ... Continue Reading ... ... picture) and Deputy Controller Abdulla Algeen (small picture on the right) have ...
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft ... 8.8% over the next decade to reach approximately $14.21 billion by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... , ... October 12, 2017 , ... ... with the pharmaceutical and biotechnology industries to improve patient outcomes and quality of ... trends in analytical testing are being attributed to new regulatory requirements for all ...
(Date:10/11/2017)... ... October 11, 2017 , ... Personal eye wash is a basic first aid supply for ... time. So which eye do you rinse first if a dangerous substance enters both eyes? ... Eye Wash with its unique dual eye piece. , “Whether its dirt and debris, ...
(Date:10/11/2017)... the Netherlands and LAGUNA HILLS, Calif. ... The Institute of Cancer Research, London ... use MMprofilerâ„¢ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients ... trial known as MUK nine . The University of ... trial, which is partly funded by Myeloma UK, and ICR ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
Breaking Biology Technology: