Navigation Links
Mimicking nature at the nanoscale: Selective transport across a biomimetic nanopore
Date:6/20/2011

Researchers at Delft University of Technology and the University of Basel have established a biomimetic nanopore that provides a unique test and measurement platform for the way that proteins move into a cell's nucleus. In the journal Nature Nanotechnology (June 19 - online), they report an artificial nanopore that is functionalized with key proteins which mimicks the natural nuclear pore. Upon testing the transport of individual proteins through the biomimetic pore, they found that most proteins cannot move through, but some specific ones can indeed pass. This is the hallmark of the intriguing selectivity that is also found in natural pores. The biomimetic pore is fully functional and can be used as a testing platform for studies of drug delivery into a cell's nucleus.

The nuclear pore complex

"Human cells have a nucleus, and proteins and RNA need to get in and out. This is regulated by small holes, called nuclear pore complexes. These are essential biological pores that act as gatekeepers of the cell nucleus. They transport proteins and RNA in and out of the nucleus in a highly selective manner, which means that some go through but others are blocked from passing. There is much debate on how this intriguing selectivity is achieved. Given the fact that it is very difficult to perform high-resolution measurements in the complex environment of the living cell, the exact mechanism is hard to resolve." Professor Cees Dekker, director of the Kavli Institute of Nanoscience at Delft and leader of this research, explains. In the new research by Dekker's group in collaboration with the group of dr. Roderick Lim of the University of Basel, they were able to make a biomimetic nanopore a synthetic pore that imitates the nuclear pore which acts as a new, powerful platform to monitor transport of individual proteins across.

Biomimetic nanopore

Dekker: "One promising approach to study this nuclear transport is biomimetics t
'/>"/>

Contact: Prof. Cees Dekker
c.dekker@tudelft.nl
Delft University of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mimicking nature, water-based artificial leaf produces electricity
2. Boston Univ., Veterans Affairs find sports brain trauma may cause disease mimicking ALS
3. Wildlife Conservation Society finds wild cat mimicking monkey calls
4. Some vocal-mimicking animals, particularly parrots, can move to a musical beat
5. GigaBlitz will turn high-resolution images of nature into global inventory of organisms, habitats
6. Nanotechnologists must take lessons from nature
7. How natures best ideas inspire innovative new technologies
8. Nature helps to solve a sticky problem
9. 2011 PerkinElmer Signature Genomic Laboratories Travel Award winner announced
10. Nature paper calls for carbon labeling
11. New data published in Nature Genetics demonstrate that tiny LNA-based compounds developed by Santaris Pharma A/S inhibit entire disease-associated microRNA families
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... One day about eight years ago, Katia Silvera , ... her father were on a field trip in a mountainous ... they had never seen before. , Unable to identify it, ... The orchid turned out to be an unnamed species. So ... . , "Lophiaris" is the genus name, comprising about 40 ...
(Date:4/17/2014)... of forests in the Amazon help create tinderbox ... rapid and widespread forest loss during drought years, ... show that forests in the Amazon could reach ... forest fires lead to large-scale loss of trees, ... professor of geography, Penn State. , "We documented ...
(Date:4/17/2014)... Current Biology on April 17 have discovered little-known ... insects, which represent four distinct but related species in ... of an animal with sex-reversed genitalia. , "Although ... Neotrogla is the only example in which ... from Hokkaido University in Japan. , During copulation, which ...
Breaking Biology News(10 mins):Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3In sex-reversed cave insects, females have the penises 2
... Mannitol, a sugar alcohol produced by fungi, bacteria, and algae, ... sweetener is also used in the medical field it,s ... excess fluids and used during surgery as a substance that ... drugs. Now Profs. Ehud Gazit and Daniel Segal of ...
... populations are declining worldwide and a major cause is a ... two-year study shows they can also die from this pathogen, ... that just spreads the disease. When researchers raised the ... least one strain of this pathogen, Batrachochytrium dendrobatidis , ...
... SAN FRANCISCO (June 16, 2013)Male mice who were fed a ... offspring who also had higher levels of body fat, a ... primarily in male offspring, despite their consumption of a low-fat ... Endocrine Society in San Francisco, Calif. , "We,ve identified a ...
Cached Biology News:Artificial sweetener a potential treatment for Parkinson's disease 2Bullfrogs may help spread deadly amphibian fungus, but also die from it 2Obese male mice father offspring with higher levels of body fat 2
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled ... 2pm EST (11am PST), “Natural Language Processing: Converting Raw ... technology can turn raw, heterogeneous data into actionable knowledge ... online webinar will last approximately one hour. , Synopsis: ...
(Date:1/14/2014)... The largest international professional organization of scientists ... derivatives thereof has endorsed an educational program that ... challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural Product ...
(Date:1/14/2014)... 2014 Global Record Systems, LLC, ... technology solutions for patients, physicians, the biopharmaceutical industry, ... today the signing of a three-year Research Collaboration ... Administration (FDA). This initiative is designed to ...
(Date:1/14/2014)... Altadena, CA (PRWEB) January 14, 2014 ... Angeles County), California, and Montreal, Canada, has big ideas ... and non-fiction. The press's goals are to produce high-quality, ... e-books to support local businesses. , The first ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... March 7, 2012 Molecular Detection Inc. (MDI), ... the speed and accuracy of infectious disease diagnosis, ... million financing.  The funds are primarily being used ... the detection of sepsis and gastrointestinal (GI) diseases.  ...
... 2012   Proteonomix, Inc. (OTC/BB: PROT) announced today ... institutional investors, pursuant to which the Company has agreed ... stock at an aggregate purchase price of approximately $3.8 ... shares of Proteonomix common stock) and Series A, Series ...
... including Drexel University,s Dr. Yury Gogotsi has given the ... of the electrodes of supercapacitors the low-cost, lightweight ... many other applications. In a piece published in the ... and his collaborators from universities in France and England, ...
Cached Biology Technology:Molecular Detection Inc. Completes $1.5 Million Financing to Advance New Tests for Sepsis and GI Disorders 2Molecular Detection Inc. Completes $1.5 Million Financing to Advance New Tests for Sepsis and GI Disorders 3Molecular Detection Inc. Completes $1.5 Million Financing to Advance New Tests for Sepsis and GI Disorders 4Proteonomix Announces a Private Placement of $3.8 Million 2Proteonomix Announces a Private Placement of $3.8 Million 3Proteonomix Announces a Private Placement of $3.8 Million 4Drexel's Gogotsi and team advance understanding of energy storage mechanisms in Nature Materials 2
MultiWash III w/ 12-portStandard Manifold...
...
... Performance, 5 ml. The same high ... Streptavidin columns for fast, reliable purification ... Tricorn 5/50 GL, XK 16/20, or ... are required.Extremely useful for exploiting either ...
...
Biology Products: