Navigation Links
Mimicking natural evolution with 'promiscuous reactions' to improve the diversity of drugs
Date:8/24/2014

A revolutionary new scientific method developed at the University of Leeds will improve the diversity of 'biologically active molecules', such as antibiotics and anti-cancer agents.

The researchers, who report their findings online today in the journal Nature Chemistry, took their inspiration from evolution in nature. The research may uncover new pharmaceutical drugs that traditional methods would never have found.

"Nature produces some amazing structures with really interesting biological activity, but the plant or animal did not design them. Instead the organisms gradually evolved both the chemical structures and the methods to produce them over millennia because they were of benefit. We wanted to capture the essence of this in our approach to discovering new drugs," said George Karageorgis, a PhD student from the School of Chemistry and the Astbury Centre for Structural Molecular Biology at the University of Leeds, and first author of the study.

The traditional method for discovering new drugs involves preparing new biologically active molecules by adjusting the chemical structure of an existing one slightly and analysing the results. This trial and error method is both time consuming and limits the variety of new types of drugs that are developed.

"There is a known problem with limited diversity in drug discovery. It's like a baker always going to the same storage cupboard and using the same ingredients, yet hoping to create something that tastes different," said Dr Stuart Warriner from the School of Chemistry and the Astbury Centre for Structural Molecular Biology at the University of Leeds, a co-author of the research paper.

"Our novel approach is like taking lots of different ingredients including things you may never think will work together and trying different combinations of these in each cup of a cupcake tray. If the result 'tastes' promising then we use this as the starting point for anoth
'/>"/>

Contact: Sarah Reed
s.j.reed@leeds.ac.uk
44-011-334-34196
University of Leeds
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mimicking living cells: Synthesizing ribosomes
2. Combinations of estrogen-mimicking chemicals found to strongly distort hormone action
3. Penn team mimicking a natural defense against malaria to develop new treatments
4. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
5. Hormone-mimicking chemicals cause inter-species mating
6. A semi-artificial leaf faster than natural photosynthesis
7. How long does it take to make a natural fracture?
8. The Rim Fire 1 year later: A natural experiment in fire ecology and management
9. Natural-terrain schoolyards reduce childrens stress, says Colorado University-Boulder study
10. A natural way to monitor, and possibly control populations of, stink bugs
11. Mouse study: Natural birth may strengthen the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)...   Marvin Test Solutions , a trusted ... military, aerospace, and manufacturing organizations, today announced the ... TS-900 PXI semiconductor test platform . The TS-960 ... to customers at a fraction of the footprint ... "Our semiconductor customers asked for ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/21/2014)... 20, 2014 Strict laws against distracted driving ... the North American and European automotive sector towards gesture ... recognition systems that are intuitive and able to retrieve ... industry. New analysis from Frost & ... in Europe and ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... Soybean production has continued to increase in the Northeast ... the crop and many experienced growers planting alongside corn crops. ... with a corn planter in 30-inch rows instead of 7.5-inch ... a Cornell University scientist, investigated the response of two soybean ...
... L. Boren announced today that OU is establishing an ... expertise to benefit Oklahoma and the nation, including emerging ... led by a national expert, who will be appointed ... million gift from Corix, a multi-utility infrastructure company, which ...
... grant totaling $2.2 million shows how the University of ... using technology to advance the cutting-edge field of personalized ... their genetic make-up. The grant also highlights the ... Institute (CCTSI) to bring scientific discoveries to the bedside ...
Cached Biology News:OU establishes a new water and sustainability institute 2OU establishes a new water and sustainability institute 3Personalizing medicine 2Personalizing medicine 3
(Date:12/22/2014)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... development of autologous cell therapies, announced today the publication ... in conjunction with co-authors from Kyoto University and the ... ongoing clinical research using dermal sheath cup (DSC) cells ... The paper entitled " Hair Follicle Dermal Stem Cells ...
(Date:12/22/2014)... Calif. , Dec. 22, 2014  ( www.competitivehealth.com ... CoPatient, an online medical bill review and advocacy service, ... in the FREE WellCard Savings discount health services marketplace. ... bill that was more than they expected to pay. ... reduce health care costs, WellCard Savings is pleased to ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced a new ... network of more than 20 contributing fertility practices ... access to a national pool of frozen donor ... of Memphis is the only fertility clinic in the ... Dr. William Kutteh , director of Fertility Associates of ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of ... Nick Maroulis, Pharm.D. to the newly created position of ... this position, Dr. Maroulis will continue to manage the ... our multi-site pharmacies as the company expands. Dr. Maroulis ... time he has served in many different capacities in ...
Breaking Biology Technology:Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... 4, 2011 Enox Biopharma, Inc., a leader in the ... today announced that it has appointed John C. Rewcastle, Ph.D., ... Enox, Dr. Rewcastle served as Medical Director of EDAP TMS ... Medical, a private medical device company. Prior to this, he ...
... Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX ) today announced ... presenting at the 29th Annual J.P. Morgan Healthcare Conference, being ... in San Francisco. Mr. Bentsur,s presentation is scheduled to take ... p.m. EST). A live audio webcast of Mr. ...
... 4, 2011 Reportlinker.com announces ... report is available in its ... title=,The 2011 Clinical Chemistry And ... Product Development Opportunities And Business ...
Cached Biology Technology:Enox Biopharma, Inc. Appoints Dr. John Rewcastle as CEO 2Enox Biopharma, Inc. Appoints Dr. John Rewcastle as CEO 3Keryx Biopharmaceuticals to Present at 29th Annual J.P. Morgan Healthcare Conference 2Reportlinker Adds The 2011 Clinical Chemistry And Immunodiagnostics Markets US, Europe, Japan: Product Development Opportunities And Business Expansion Strategies For Instrument And Reagent Suppliers 2
... Radiolabeled Ligands\n\nReceptor-related research has long been enabled ... ligands selected to keep pace with new ... products and services for receptor research and ... If you do not find exactly what ...
... and SYBR Safe DNA Gel Stain combo offers these ... buying these same products separately ... bromide Eliminates risks to ... and RNA fragments from 100 bp to >30 kb. ...
... easily imported for data analysis , Automatic grid, ... template assignment ... Extensive background and signal options to optimize, ... results , ...
... MATra-si Reagent optimized for siRNA applications, contains ... with the nucleic acid of interest. Exploiting ... is then rapidly drawn towards and delivered ... transfection. MATra-si Reagent can be used for ...
Biology Products: