Navigation Links
Milk and risk of renal cell cancer: Genetic research sheds new light

PHILADELPHIA While previous research had suggested that drinking milk was related to factors that may increase the risk of renal cell cancer, results of a recent study exploiting the genetic contribution to variation in milk consumption suggest that this may not be the case.

"The data in this study provide no concrete evidence of a need to alter milk drinking in any way," said lead researcher Nicholas Timpson, Ph.D., lecturer in genetic epidemiology at the MRC CAiTE Center in the department of social medicine at the University of Bristol, United Kingdom. "If anything, the failure of genetic findings to replicate the association between milk and renal cell cancer suggests that fears that milk consumption might elevate cancer risk are likely to be unfounded."

These study results are published in the May issue of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Previously reported studies suggested a connection between milk intake and renal cell carcinoma risk, and whether this represents a causal association or is the result of bias is currently unclear. Timpson and colleagues used a genetic marker to try to help untangle this observation.

From 1999 through 2003 the researchers conducted a large, hospital-based, case-control study from four central and eastern European countries.

Using observational, genetic and phenotypic data, they determined whether the genetic variant at the gene MCM6 known to be associated with lactose tolerance may be used as a non-confounded and unbiased marker for milk consumption's link to cancer risk.

For adult milk drinkers vs. non-milk drinkers in this study, the difference in the odds of renal cell carcinoma was approximately 35 percent. However, when assessing the relationship in a more direct way by using genetic data there was no association between the two.

"We found evidence for the often-questioned relationship between milk consumption and cancer, yet when we used genotypes to verify this relationship, there was no corroboratory evidence," Timpson said. "This does suggest that the basic findings may be subject to the kinds of biases and inaccuracies that often upset epidemiological research, but that this study would need to be undertaken on a much larger scale in order to verify these initial findings."

Johanna Lampe, Ph.D., an editorial board member of Cancer Epidemiology, Biomarkers & Prevention who is not associated with this study, said this study demonstrates the complexities of evaluating dietary exposures and cancer risk.

"These results are a reminder to proceed with caution when interpreting data that suggest an association between intake of specific foods and risk of a particular cancer. Human diet is complex and typically involves adherence to certain dietary patterns that are also tied to other lifestyle behaviors," said Lampe, full member and nutrition scientist in the division of public health sciences at Fred Hutchinson Cancer Research Center, Seattle, Wash.


Contact: Tara Yates
American Association for Cancer Research

Related biology news :

1. Revolutionary drug could be new hope for adrenal cancer patients
2. DuoCort: New chronotherapy for adrenal insufficiency
3. New gene variant identified for nondiabetic end stage renal disease in African-Americans
4. Doctors may be giving the wrong dosage of adrenaline in an emergency because of labelling
5. Cancer: Primitive gene discovered
6. Cancer: The cost of being smarter than chimps?
7. From cars to cancer: UH professor employs auto industry tools for tumor therapy
8. Early detection of lung cancer: New data presented at multidisciplinary meeting
9. Cancer: Another step towards medication
10. Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
11. Hispanic women and breast cancer: An understudied group
Post Your Comments:
Related Image:
Milk and risk of renal cell cancer: Genetic research sheds new light
(Date:6/15/2016)... 2016 Transparency Market Research ... Market by Application Market - Global Industry Analysis Size Share ... the report, the  global gesture recognition market  was ... is estimated to grow at a CAGR of ... Increasing application of gesture recognition technology ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is ... partnership with VoicePass. By working together, ... experience.  Because VoiceIt and VoicePass take slightly different ... engines increases both security and usability. ... excitement about this new partnership. "This ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... , ... June 23, 2016 , ... STACS DNA Inc., ... Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field ... DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
Breaking Biology Technology: