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Milestone in live microscopy focus of $2 million NIH grant
Date:5/13/2009

minate specimens.

In order to create the third-generation TEM, which Browning and his team are calling a "Bio-DTEM," three new elements must be incorporated into the design: a custom-built system to hold an ultra-thin layer of fluid containing the biological sample to be imaged; a short-exposure-time imaging mode, to avoid the blurring problem created when molecules move through their fluid medium; and a new generation of scientific instrumentation to deliver optimum image contrast for biological samples and to correct image distortions generated by lenses.

"It should be noted that each of the components of our proposed new system are commercially available," said Browning. "Our work will be to bring them all together into a single instrument. With this grant from the NIH, I'm confident that we will be able to do so."

Five UC Davis colleagues will collaborate with Browning on the project: Peter Armstrong, Jodi Nunnari and Jon Scholey, professors of molecular and cellular biology; Wolf Heyer, professor of microbiology; and Stephen Kowalczykowski, distinguished professor of microbiology. In July, Browning will add an appointment in the Department of Molecular and Cellular Biology to his academic positions at UC Davis.


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Contact: Liese Greensfelder
lgreensfelder@ucdavis.edu
530-752-6101
University of California - Davis
Source:Eurekalert  

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