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Milestone in fight against deadly disease
Date:12/7/2010

e, VA), the University of Texas Southwestern Medical Center at Dallas (Dallas, TX), and the Washington University School of Medicine (St. Louis, MO), in addition to Northwestern University.

Mapping the structures of drug-resistant bacteria is also a priority for the two centers. "Drug-resistant bacteria are an increasing threat to us and we need to get new drugs to stay ahead of them," said Anderson, Principal Investigator of CSGID. "The recent years have brought not only an avalanche of new macromolecular structures, but also significant advances in the protein structure determination methodology that are now making their way into drug discovery. We provide the structural information so that in the future companies can develop new drugs to overcome resistance."

The structures solved by the Centers are immediately made available to the international scientific community through the NIH-supported Protein Data Bank (www.pdb.org), providing a "blueprint" for development of new drugs, vaccines and diagnostics.

The Centers are on track to ultimately identify nearly 500 more structures by the end of the current five-year NIH contract in 2012. Apart from the protein structures, the two Centers make available to the scientific community all the clones and purified proteins that they produce in order to facilitate a global collaboration in the fight against deadly diseases.


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Contact: Erin White
ewhite@northwestern.edu
847-491-4888
Northwestern University
Source:Eurekalert

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