SEATTLE & CHICAGO Scientists at Seattle Biomedical Research Institute (Seattle BioMed) and Northwestern University Feinberg School of Medicine have reached a major milestone in the effort to wipe out some of the most lethal diseases on the planet. As leaders of two large structural genomics centers, they've experimentally determined 500 three-dimensional protein structures from a number of bacterial and protozoan pathogens, which could potentially lead to new drugs, vaccines and diagnostics to combat deadly infectious diseases. Some of the structures solved by the centers come from well-known, headline-grabbing organisms, like the H1N1 flu virus. Portraits of these protein structures, ranging from the plague, cholera and rabies to H1N1 can been seen on the websites www.csgid.org and www.ssgcid.org.
The Center for Structural Genomics of Infectious Diseases (CSGID), which is led by Wayne Anderson, Professor of Molecular Pharmacology and Biological Chemistry at Feinberg (Chicago, IL), and the Seattle Structural Genomics Center for Infectious Disease (SSGCID), led by Peter Myler, Full Member at Seattle BioMed and Affiliate Professor of Global Health and Medical Education & Biomedical Informatics at the University of Washington, were created in 2007 through contracts from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). The Centers' mission is to apply genome-scale approaches in solving protein structures from biodefense organisms, as well as those causing emerging and re-emerging diseases.
"By determining the three-dimensional structure of these proteins, we can identify important pockets or clefts and design small molecules which will disrupt their disease-causing function," said Myler. "Each solved structure provides an important piece of new knowledge for scientists about a wide variety of diseases."
|Contact: Erin White|