Navigation Links
Milestone discovery in cell behaviors

A team of international molecular scientists, led by a Monash University researcher has discovered a new, fast mechanism by which cells communicate change for example their location during spreading of a cancer in the human body to adjacent cells.

The discovery sheds new light on cell behaviour and could lead to the development on new drugs to combat diseases such as cancer, rheumatoid arthritis and Alzheimer's disease.

The team led by Monash University Associate Professor Martin Lackmann found that for one particular communicator between cells, an enzyme known as A-Disintegrin-And-Metalloprotease 10 (ADAM10), a change in the shape of its contender (communication partner) will start the communication process.

Scientists are interested in ADAM10 - and the proteins that are split by this protease because it is critical in cellular mechanisms that underlie several major diseases.

"This communication process between cells forms the basis for the way in which certain diseases progress. This discovery will change how we understand cell behaviour and change how we consider the design of therapeutic drugs in this area" Associate Professor Lackmann said.

"This new concept in understanding of how cells communicate identifies a process that is much simpler than previously thought and which will profoundly impact the direction of future biomedical research in this area," he said.

"The research team found that instead of using complex signalling pathways, this communication system is really very direct and simple. In this case it is a transient switch in the overall shape of the contending cell surface receptor itself which activates the ADAM10 protease to communicate this change and its functional consequences to a neighbouring cell.

"The discovery of this switch opens new avenues for the development of drugs that recognise this changed shape and prevent the signalling to other cells, thus slowing or even halting the spread of disease.

The discovery was made using fluorescence and electron microscopy techniques, which allowed the observation of intact cells at single molecule resolution the changes in the shape of the cell surface receptor that occur during cell-to-cell communication.

The discovery was published online today in the open-access journal PLoS Biology.


Contact: Samantha Blair
Monash University

Related biology news :

1. A new milestone in the GMES Space Component Program successfully achieved
2. Secure Services Corp. Achieves Milestone in United States Identity Protection with the Launch of the SSC SHAPE Card Management Solution
3. A gentle touch for better control, a quantum mechanical con, and milestone PRL papers
4. Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen
5. Milestone achieved toward production of malaria treatment using synthetic biology and fermentation
6. ExcellGene and Khner achieved milestone in development of novel 250 Liter mammalian cell culture bioreactors
7. Milestone in live microscopy focus of $2 million NIH grant
8. Lockheed Martin Team Completes Key Design Milestone on Federal Bureau of Investigations Next Generation Identification Program
9. Discovery may help defang viruses
10. Stomach stem cell discovery could bring cancer insights
11. Symposium marks 30th anniversary of discovery of third domain of life
Post Your Comments:
(Date:11/9/2015)... Nov. 09, 2015 ... of the "Global Law Enforcement Biometrics ... --> ) has announced ... Enforcement Biometrics Market 2015-2019" report to ... Markets ( ) has announced the ...
(Date:10/29/2015)... , Oct. 29, 2015  The J. Craig ... report titled, "DNA Synthesis and Biosecurity: Lessons Learned and ... Department of Health and Human Services guidance for synthetic ... 2010. --> --> ... also has the potential to pose unique biosecurity threats. ...
(Date:10/29/2015)... Oct. 29, 2015 Today, LifeBEAM ... partnership with 2XU, a global leader in technical ... smart hat with advanced bio-sensing technology. The hat ... to monitor key biometrics to improve overall training ... the two companies will bring together the most advanced ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... and HOLLISTON, Mass. , Nov. 25, ... HART ), a biotechnology company developing bioengineered organ ... Jim McGorry will present at the LD Micro ... at 2:30 p.m. PT. The presentation will be webcast ... days. Management will also be available at the conference ...
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... its business and prospects remain fundamentally strong and ... (zoptarelin doxorubicin) recently received DSMB recommendation to continue ... following review of the final interim efficacy and ... Primary Endpoint in men with heavily pretreated castration- ...
(Date:11/25/2015)... Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) ... chat discussion at the Piper Jaffray 27th Annual Healthcare ... discussion is scheduled for Wednesday, December 2, at 8:00 ... replay will be available for 14 days after the ... NormartVP, Corporate Communications and Business Development , BrewLife(858) 875-8629 ...
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica Richman and Zachary ... in their initial angel funding process. Now, they are paying it forward to ... early stage investments in the microbiome space. In this, they join other ...
Breaking Biology Technology: