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Mild thyroid dysfunction in early pregnancy linked to serious complications
Date:6/23/2012

-hormone production. At this time, only pregnant women with clinical symptoms of hypothyroidism are routinely tested. Once diagnosed, the condition can be effectively controlled with medication that replaces natural thyroid hormone with a synthetic version.

Investigators recruited 1,000 pregnant women in their first trimester of pregnancy for the study, as part of a larger project of routine thyroid screening during early pregnancy. They then measured the level of thyroid functioning using the TSA test.

Normal thyroid function was identified in 533 patients, and 263 had mild dysfunction. The remaining patients were diagnosed with hypothyroidism and withdrawn from the study for treatment. Follow-up continued until the completion of pregnancy.

Jacob and his team then compared rates of miscarriage, stillbirth, premature labor, and low birth weight. They also analyzed several other complications, as well, but these did not differ significantly between women with normal versus moderately low thyroid functioning.

"Our conclusions are that all pregnant women need to be screened for thyroid dysfunction at their first visit," Jacob said. "This should form the basis for the national societies to make a change in their guidelines." Christian Medical College and Hospital funded the study.


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Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

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