Navigation Links
Mild thyroid dysfunction in early pregnancy linked to serious complications
Date:6/23/2012

Even moderate thyroid dysfunction during early pregnancy significantly increases the risk of serious complications, underscoring the need for universal screening in the first trimester, a new study finds. The results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

"These findings add to the now increasing evidence from previous studies that all pregnant women, irrespective of their risk for thyroid problems, probably should be screened for thyroid dysfunction within the first three months of getting pregnant," said study lead author Jubbin Jagan Jacob, M.D., associate professor at Christian Medical College and Hospital, Ludhiana in Punjab, India.

Thyroid hormone is produced by the thyroid gland, which is located in the neck, and helps regulate the process of turning food into energy. Excessively low hormone production, or hypothyroidism, may cause symptoms like fatigue, sensitivity to cold temperatures, constipation, and depression.

During pregnancy untreated, hypothyroidism is associated with an increased risk of miscarriage, stillbirth, low birth weight, and other serious complications. Although previous research has suggested that women with moderate thyroid dysfunction, or subclinical hypothyroidism, also are more likely to suffer complications, the level of risk was uncertain.

In this study, investigators found that even mild thyroid dysfunction that did not meet the criteria for hypothyroidism greatly increased the risk of serious problems. Compared to pregnant women with normal thyroid function, the risk was:

  • doubled for miscarriage (≤20 weeks of pregnancy), premature labor, and low birth weight
  • seven times greater for still birth

Screening for hypothyroidism involves taking a thorough history of symptoms, as well as a simple blood test to measure levels of another hormone, called thyroid-stimulating-hormone, or TSH, that promotes thyroid-hormone production. At this time, only pregnant women with clinical symptoms of hypothyroidism are routinely tested. Once diagnosed, the condition can be effectively controlled with medication that replaces natural thyroid hormone with a synthetic version.

Investigators recruited 1,000 pregnant women in their first trimester of pregnancy for the study, as part of a larger project of routine thyroid screening during early pregnancy. They then measured the level of thyroid functioning using the TSA test.

Normal thyroid function was identified in 533 patients, and 263 had mild dysfunction. The remaining patients were diagnosed with hypothyroidism and withdrawn from the study for treatment. Follow-up continued until the completion of pregnancy.

Jacob and his team then compared rates of miscarriage, stillbirth, premature labor, and low birth weight. They also analyzed several other complications, as well, but these did not differ significantly between women with normal versus moderately low thyroid functioning.

"Our conclusions are that all pregnant women need to be screened for thyroid dysfunction at their first visit," Jacob said. "This should form the basis for the national societies to make a change in their guidelines." Christian Medical College and Hospital funded the study.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related biology news :

1. 23andMe identifies 5 significant genetic associations for hypothyroidism
2. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
3. Regenerated cells may restore vision after corneal dysfunction
4. Has modern science become dysfunctional?
5. Environmental estrogens affect early developmental activity in zebrafish
6. Autism Speaks awards nearly $2.9 million to fund autism research
7. Lab-engineered kidney project reaches early milestone
8. Early Bird Offers on Healthcare and Biotechnology Conferences, Save Up To 20% by Registering with Global Information
9. Early Bird Discounts Available on International Healthcare and Biotechnology Conferences, Save Up To $600 with Global Information
10. Clinical trials for Alzheimers disease preventative drug to begin early 2013
11. Nearly one-tenth of hemispheres mammals unlikely to outrun climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... HANOVER , Allemagne, March 14, 2016 /PRNewswire/ ... http://www.apimages.com ) - --> - ... ) - --> ... les solutions biométriques, fournit de nouveaux lecteurs d,empreintes ... lecteur LF10 de DERMALOG sera utilisé pour produire ...
(Date:3/10/2016)... 10, 2016 --> ... report "Identity and Access Management Market by Component (Provisioning, ... Governance), by Organization Size, by Deployment, by Vertical, and ... MarketsandMarkets, The market is estimated to grow from USD ... 2020, at a Compound Annual Growth Rate (CAGR) of ...
(Date:3/9/2016)... , March 9, 2016 ... government identified that more than 23,000 public service employees ... had been receiving their salary unlawfully.    --> ... country,s government identified that more than 23,000 public service ... or had been receiving their salary unlawfully.    ...
Breaking Biology News(10 mins):
(Date:5/5/2016)... 2016  Why are two uber-successful former agency presidents ... launching a new venture—yet going about things in ... truly helping clients raise the value of their offerings ... different type of collaboration. The result is ... and medical device sectors. Elevate specializes in shaping and ...
(Date:5/4/2016)... ... May 05, 2016 , ... ... support the National Stroke Association during National Stroke Awareness Month in May. ... Twitter pages throughout the month. CereScan will donate $1 up to a ...
(Date:5/4/2016)... ... ... Proove Biosciences, Inc. , the commercial and research leader in personalized pain ... partnership is designed to advance research in pain genetics in an effort to bring ... new agreement, researchers at Proove Biosciences are able to collaborate with Luda Diatechnko, MD, ...
(Date:5/4/2016)... ... May 04, 2016 , ... The Children’s Tumor Foundation ... that causes tumors to grow on nerves throughout the body. It affects 1 in ... numerous community events held during the month of May, as well as online activities, ...
Breaking Biology Technology: