Navigation Links
Mild blast injury causes molecular changes in brain akin to Alzheimer, Pitt team says
Date:4/24/2013

A multicenter study led by scientists at the University of Pittsburgh School of Medicine shows that mild traumatic brain injury after blast exposure produces inflammation, oxidative stress and gene activation patterns akin to disorders of memory processing such as Alzheimer's disease. Their findings were recently reported in the online version of the Journal of Neurotrauma.

Blast-induced traumatic brain injury (TBI) has become an important issue in combat casualty care, said senior investigator Patrick Kochanek, M.D., professor and vice chair of critical care medicine and director of the Safar Center for Resuscitation Research at Pitt. In many cases of mild TBI, MRI scans and other conventional imaging technology do not show overt damage to the brain.

"Our research reveals that despite the lack of a lot of obvious neuronal death, there is a lot of molecular madness going on in the brain after a blast exposure," Dr. Kochanek said. "Even subtle injuries resulted in significant alterations of brain chemistry."

The research team developed a rat model to examine whether mild blast exposure in a device called a shock tube caused any changes in the brain even if there was no indication of direct cell death, such as bleeding. Brain tissues of rats exposed to blast and to a sham procedure were tested two and 24 hours after the injury.

Gene activity patterns, which shifted over time, resembled patterns seen in neurodegenerative diseases, particularly Alzheimer's, Dr. Kochanek noted. Markers of inflammation and oxidative stress, which reflects disruptions of cell signaling, were elevated, but there was no indication of energy failure that would be seen with poor tissue oxygenation.

"It appears that although the neurons don't die after a mild injury, they do sustain damage," he said. "It remains to be seen what multiple exposures, meaning repeat concussions, do to the brain over the long term."


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. Nearly half of veterans found with blast concussions might have hormone deficiencies
2. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
3. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
4. US-born Latinas at great risk of having babies with retinoblastoma
5. Heart Damage Repaired By Reprogramming Resident Fibroblasts into Functioning Heart Cells
6. The State of Spinal Cord Injury Grand Rounds
7. Restoring paretic hand function via an artificial neural connection bridging spinal cord injury
8. Returning military personnel to duty following severe injury to the lower extremity
9. Potential early indicator of kidney injury identified
10. New therapy for heart failure may enhance bodys stem cell response at cardiovascular injury site
11. Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/4/2019)... MEMPHIS, Tenn. (PRWEB) , ... June 04, 2019 ... ... in contract manufacturing of orthopedic medical devices, today announced Q1-19 revenues of $31M, ... the industry combined with successful roll-out of strategic investments & operational excellence initiatives ...
(Date:6/4/2019)... ... , ... Most preclinical EEG visualization platforms offer tools intended ... on variations of amplitude, frequency or spike train detection. In the clinic, however, ... complexity and variability of the signal, and automation tools are used only in ...
(Date:6/1/2019)... FREDERICK, Md. (PRWEB) , ... May 31, 2019 ... ... legal firm Wilson Sonsini Goodrich & Rosati recently invested in BioFactura’s $6M Series ... WSGR, BioFactura is now securing value-added institutional investors who bring significant financial and ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today in ... are able to incorporate into human CD34+ cells, modifying their gene expression and ... increased the cells’ ability to lodge into bone marrow. This research performed by ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... from the USPTO providing proprietary interest to our methodology, processes, and diagnostic ... DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our proprietary sleep scoring ...
(Date:5/31/2019)... ... May 30, 2019 , ... A study released today in ... for the sustained release of human placental stem cell (HPSC)-derived conditioned medium (CM) ... deliver CM into the injured kidney, where it helped restore function and regenerate ...
(Date:5/15/2019)... , ... May 15, 2019 , ... Milton Hershey School® ... recognition for his work within the biomedical industry, where he is changing lives by ... devices. , “William Harding epitomizes the vision of our founders – Milton and ...
Breaking Biology Technology: