Navigation Links
Mild blast injury causes molecular changes in brain akin to Alzheimer, Pitt team says
Date:4/24/2013

A multicenter study led by scientists at the University of Pittsburgh School of Medicine shows that mild traumatic brain injury after blast exposure produces inflammation, oxidative stress and gene activation patterns akin to disorders of memory processing such as Alzheimer's disease. Their findings were recently reported in the online version of the Journal of Neurotrauma.

Blast-induced traumatic brain injury (TBI) has become an important issue in combat casualty care, said senior investigator Patrick Kochanek, M.D., professor and vice chair of critical care medicine and director of the Safar Center for Resuscitation Research at Pitt. In many cases of mild TBI, MRI scans and other conventional imaging technology do not show overt damage to the brain.

"Our research reveals that despite the lack of a lot of obvious neuronal death, there is a lot of molecular madness going on in the brain after a blast exposure," Dr. Kochanek said. "Even subtle injuries resulted in significant alterations of brain chemistry."

The research team developed a rat model to examine whether mild blast exposure in a device called a shock tube caused any changes in the brain even if there was no indication of direct cell death, such as bleeding. Brain tissues of rats exposed to blast and to a sham procedure were tested two and 24 hours after the injury.

Gene activity patterns, which shifted over time, resembled patterns seen in neurodegenerative diseases, particularly Alzheimer's, Dr. Kochanek noted. Markers of inflammation and oxidative stress, which reflects disruptions of cell signaling, were elevated, but there was no indication of energy failure that would be seen with poor tissue oxygenation.

"It appears that although the neurons don't die after a mild injury, they do sustain damage," he said. "It remains to be seen what multiple exposures, meaning repeat concussions, do to the brain over the long term."


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1

Related biology news :

1. Nearly half of veterans found with blast concussions might have hormone deficiencies
2. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
3. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
4. US-born Latinas at great risk of having babies with retinoblastoma
5. Heart Damage Repaired By Reprogramming Resident Fibroblasts into Functioning Heart Cells
6. The State of Spinal Cord Injury Grand Rounds
7. Restoring paretic hand function via an artificial neural connection bridging spinal cord injury
8. Returning military personnel to duty following severe injury to the lower extremity
9. Potential early indicator of kidney injury identified
10. New therapy for heart failure may enhance bodys stem cell response at cardiovascular injury site
11. Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2019)... ... September 17, 2019 , ... VISTAAR released ... primary strategy or as re-assurance / 2nd opinion to their internal strategies they formed ... of users when going into new markets, or planning to change their product elements ...
(Date:9/17/2019)... ... September 17, 2019 , ... Last week, Blackrock ... engineers from the Medical University of Warsaw, met at the Presidential Palace of ... creating a neuroprosthetic system as part of an initiative called "Startups in the ...
(Date:9/17/2019)... ... 17, 2019 , ... Dual-board certified periodontist and implant surgeon, ... of Implant Dentistry (ASID) Accreditation Courses. His lecture, “Understanding the Soft and Hard ... Modern Implant Dentistry course. Dr. Kim’s expertise comes from years of experience providing ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... August 13, 2019 , ... ... on prepackaged mobile phases for QC laboratories. After gaining a few significant clients, ... sciences approach into a valued supplier of manufacturing processing solutions, including reagents for ...
(Date:8/7/2019)... (PRWEB) , ... August 07, 2019 , ... Locus Agricultural ... breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , which is ... year—the largest impact any approach has offered to date. Results from the treatment of ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... for characterizing microbiome populations down to the strain level, has announced partnerships with ... and other products to companies and research organizations in Australia, Benelux, Indonesia, Korea, ...
(Date:8/6/2019)... Ill. (PRWEB) , ... August 06, 2019 , ... ... Southern Illinois University Edwardsville for the launch of a community project that will ... The three-year grant supports the project, entitled “A Youth-Led Citizen Science Network for ...
Breaking Biology Technology: