Navigation Links
Microtubule-based strategies for promoting nerve regeneration after injury
Date:8/8/2014

After injury, damaged axons have the capacity to regenerate, but the regenerative capacity of the axon, particularly axons of the central nervous system, is quite limited. This is because the damaged axons tend to retract, because they encounter obstacles such as scar tissue and inhibitory molecules, and because their growth rates simply do not match those of a juvenile axon. Prof. Peter W. Baas from Drexel University, USA focus on microtubules as among the most important factors in encouraging injured adult axons to regenerate. Microtubules are hollow polymeric filaments composed of tubulin subunits that provide structural support for the axon. In addition to their structural role, microtubules are an important substrate for many of the molecular motor proteins responsible for intracellular transport. Microtubules are intrinsically polar structures, with their "plus" ends favored for assembly over their "minus" ends. Molecular motor proteins interact with cargo such as membranous organelles that are transported in conjunction with the motor. In the axon, the microtubules are aligned into a paraxial array with the plus ends of the microtubules directed away from the cell body, thus establishing the directionality with which different motors convey their cargo. Microtubules gather together and funnel into the hillock region of the axon and then splay apart again at sites of branch formation and within the growth cone at the tip of the elongating axon. Microtubules are relevant to axonal growth and regeneration for reasons related to all of these factors. Additionally, it appears that the dynamic properties of microtubules are critically important especially in the distal tip of the axon, for the capacity of the axon to form a viable growth cone, to turn properly in response to external cues, and to grow with the vitality typical of the developing nervous system. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 13, 2014).


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Related biology news :

1. Bowman provides strategies to engage public with climate change solutions
2. New heart repair strategies discussed at UH lecture May 15
3. New review outlines screening strategies for osteoporosis in young adults
4. Strategies to improve renewable energy feedstocks
5. Smart growth strategies curb car use, greenhouse gas emissions, SF State study suggests
6. New anti-tumor cell therapy strategies are more effective
7. Whales foraging strategies revealed by new technology
8. Dartmouth research offers new control strategies for bipolar bark beetles
9. New research on migratory behavior of oceanic whitetip sharks can help shape conservation strategies
10. Climate-smart strategies proposed for spectacular US-Canadian landscape
11. University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Microtubule-based strategies for promoting nerve regeneration after injury
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the ... the Dow Jones Industrial Average edged 0.27% lower to finish ... 0.17%. Stock-Callers.com has initiated coverage on the following equities: Infinity ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... ). Learn more about these stocks by accessing their free ...
Breaking Biology Technology: