Navigation Links
Microtubule-based strategies for promoting nerve regeneration after injury

After injury, damaged axons have the capacity to regenerate, but the regenerative capacity of the axon, particularly axons of the central nervous system, is quite limited. This is because the damaged axons tend to retract, because they encounter obstacles such as scar tissue and inhibitory molecules, and because their growth rates simply do not match those of a juvenile axon. Prof. Peter W. Baas from Drexel University, USA focus on microtubules as among the most important factors in encouraging injured adult axons to regenerate. Microtubules are hollow polymeric filaments composed of tubulin subunits that provide structural support for the axon. In addition to their structural role, microtubules are an important substrate for many of the molecular motor proteins responsible for intracellular transport. Microtubules are intrinsically polar structures, with their "plus" ends favored for assembly over their "minus" ends. Molecular motor proteins interact with cargo such as membranous organelles that are transported in conjunction with the motor. In the axon, the microtubules are aligned into a paraxial array with the plus ends of the microtubules directed away from the cell body, thus establishing the directionality with which different motors convey their cargo. Microtubules gather together and funnel into the hillock region of the axon and then splay apart again at sites of branch formation and within the growth cone at the tip of the elongating axon. Microtubules are relevant to axonal growth and regeneration for reasons related to all of these factors. Additionally, it appears that the dynamic properties of microtubules are critically important especially in the distal tip of the axon, for the capacity of the axon to form a viable growth cone, to turn properly in response to external cues, and to grow with the vitality typical of the developing nervous system. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 13, 2014).


Contact: Meng Zhao
Neural Regeneration Research

Related biology news :

1. Bowman provides strategies to engage public with climate change solutions
2. New heart repair strategies discussed at UH lecture May 15
3. New review outlines screening strategies for osteoporosis in young adults
4. Strategies to improve renewable energy feedstocks
5. Smart growth strategies curb car use, greenhouse gas emissions, SF State study suggests
6. New anti-tumor cell therapy strategies are more effective
7. Whales foraging strategies revealed by new technology
8. Dartmouth research offers new control strategies for bipolar bark beetles
9. New research on migratory behavior of oceanic whitetip sharks can help shape conservation strategies
10. Climate-smart strategies proposed for spectacular US-Canadian landscape
11. University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars
Post Your Comments:
Related Image:
Microtubule-based strategies for promoting nerve regeneration after injury
(Date:11/16/2015)... Nov 16, 2015  Synaptics Inc. (NASDAQ: ... solutions, today announced expansion of its TDDI product ... touch controller and display driver integration (TDDI) solutions ... These new TDDI products add to the previously-announced ... TD4302 (WQHD resolution), and TD4322 (FHD resolution) solutions. ...
(Date:11/12/2015)...  Arxspan has entered into an agreement with ... use of its ArxLab cloud-based suite of biological ... will support the institute,s efforts to electronically manage ... internally and with external collaborators. The ArxLab suite ... Institute,s electronic laboratory notebook, compound and assay registration, ...
(Date:11/11/2015)... MedNet Solutions , an innovative SaaS-based eClinical technology company that ... announce that it will be a Sponsor of the ... held November 17-19 in Hamburg , Germany.  ... iMedNet , MedNet,s easy-to-use, proven and affordable eClinical ... able to deliver time and cost savings of up to ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... 2015 /PRNewswire/--  Mallinckrodt plc (NYSE: MNK ), ... has closed the sale of its global contrast media ... Euronext) in a transaction valued at approximately $270 million. ... a total of approximately 1,000 employees spread across the ... Louis area. This entire workforce and the ...
(Date:11/27/2015)... PUNE, India , November 27, 2015 ... --> Growing popularity of companion ... emerging in cancer biomarkers market with pharmaceutical ... develop in-demand companion diagnostic tests. ... --> Complete report on global ...
(Date:11/26/2015)... November 26, 2015 --> ... specializing in imaging technologies, announced today that it has received ... of the Horizon 2020 European Union Framework Programme for Research ... clinical trial in breast cancer. , --> ... --> --> The study aims ...
(Date:11/25/2015)... 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) announced ... stockholder rights plan (Rights Plan) in an effort to ... (NOLs) under Section 382 of the Internal Revenue Code ... PharmAthene,s use of its NOLs could be substantially limited ... in Section 382 of the Code. In general, an ...
Breaking Biology Technology: