Navigation Links
Microscopic cells race to victory in first World Cell Race at ASCB meeting
Date:12/2/2011

DENVER, CO, December 3, 2011--A "team" of fast-moving, bone marrow stem cells from a research laboratory in Singapore has run away with the first World Cell Race, finishing first with a cellular speed record of 5.2 microns per minute (or 0.000204 inches per minute) in results announced today at the 51st Annual Meeting of the American Society for Cell Biology (ASCB).

The mesenchymal bone marrow stem cells grown at the National University of Singapore by Yuchun Liu, PhD, were one of 70 cell lines entered by labs from all over the world and raced on specially designed micro-tracks, a few microns wide and 400 microns long. The micro-tracks, donated by CYTOO Cell Architects of Grenoble, France, were coated with fibronectin, a natural substrate on which the cells could get traction. The racing cell lines were frozen for shipment to one of six labs around the globe where they were thawed, stained with fluorescent dyes, and raced against the clock. The action was video recorded for 24 hours and the times were sorted by custom software created at the Institut Curie in Paris, according to Manuel Thry, PhD, who along with Ana-Maria Lennon-Dumnil, PhD, and Matthieu Piel, PhD, organized the World Cell Race. Piel and Lennon-Dumnil are at the Institut Curie. Thry is with the Institut de Recherche en Technologies et Sciences pour le Vivant (iRTSV) in Grenoble, France. The institute is part of the Commissariat l'Energie Atomique (CEA).

"We measured the position and speeds of all individual cells in each group," says Thry. "For each cell line, we then determined the fastest run over 400 microns."

Thry says the idea for a cell race came to them at last year's ASCB Annual Meeting in Philadelphia where the three French scientists were struck by the large number of papers and the lively discussions about cell migration. How cells move is one of the hottest fields in research today because of the implications in cancer where motilitythe ability of tumor cells to move autonomously--is critical to understanding how cancer metastasizes. Cell movement is also vital to normal biology including embryonic development and human growth. Thry says that the World Cell Race was a way to mix the fun of a scientific sporting event with serious research into how speed reflects the nature of certain cells.

The results of the race were announced in Denver as the climax of an ASCB Special Interest Subgroup titled, "Mechanisms for Rapid Cell Migration." More information on cell mobility can be found at: http://www.ascb.org/meetings/subgroup/subgroup.cfm#I

Finishing second and third place were cell lines provided by Odile Filhol-Cochet, PhD, of iRTSV/CEA in France. The second place winners were "wild type" normal mammary breast epithelial cells, clocked along the 400 micron track at 3.2 microns per minute. Third place award went to a cell culture of these mammary epithelial cells altered in the lab with a knocked-down casein kinase 2 and an overactive Ras pathway. The re-engineered cells roared down the track at 2.7 microns per minute.

In fourth place were human keratinocytes cultured from samples taken from patients suffering from Kindler syndrome, a rare genetic skin disorder, entered by Rumena Begum of King's College London, UK. Their speed over 400 microns was 2.5 microns per minute.

The winners will receive a Nikon camera and a World Cell Race medal.

In addition to being enjoyable, the first World Cell Race generated valuable data. "Data analysis revealed an unknown feature of cell migration," says Thry. "Fast cells were persistent⎯they rarely changed the direction of their migration. Slow cells were not persistent. They went back and forth." Correlating the speed of cells to their invasive behavior in cancer, for example, could uncover new approaches to treatment, Thry believes.

If the First World Cell Race is a success at ASCB, Thry hopes for a second running next year. "Maybe with additional games," he suggests. "Swimming and weightlifting."


'/>"/>

Contact: John Fleischman
jfleischman@ascb.org
513-706-0212
American Society for Cell Biology
Source:Eurekalert

Related biology news :

1. Nanotubes key to microscopic mechanics
2. Rising greenhouse gases profoundly impact microscopic marine life
3. New microscopic life aboard the RMS Titanic
4. Medical imaging breakthrough uses light and sound to see microscopic details inside our bodies
5. Microscopic solutions to worlds biggest problems
6. UW-built device reveals invisible world teeming with microscopic algae
7. New study documents use of hormone progesterone in simple microscopic aquatic animals
8. New technology enables machines to detect microscopic pathogens in water
9. Wine vine: Microscopic photography reveals bacteria destroying grape plant cell wall
10. Michigan State University study sheds light on microscopic flower petal ridges
11. Mighty diatoms: Global climate feedback from microscopic algae
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/28/2016)... , April 28, 2016 First quarter ... (139.9), up 966% compared with the first quarter of 2015 ... totaled SEK 589.1 M (loss: 18.8) and the operating margin was ... (loss: 0.32) Cash flow from operations was SEK 249.9 ... 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. The ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. Hays ... DNA as a Field Application Specialist. , “I am thrilled that Dr. Young ... DNA. “In further expanding our capacity as a scientific integrator, Hays brings a wealth ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... CA (PRWEB) , ... June 23, 2016 , ... ... software, is exhibiting at the Pennsylvania Convention Center and will showcase its product’s ... conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials ...
(Date:6/23/2016)... 2016  Amgen (NASDAQ: AMGN ) today ... life sciences incubator to accelerate the development of ... space at QB3@953 was created to help high-potential life ... many early stage organizations - access to laboratory infrastructure. ... launched two "Amgen Golden Ticket" awards, providing each winner ...
Breaking Biology Technology: