Navigation Links
Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer
Date:4/21/2009

DENVER, CO and AUCKLAND, NZ (April 21, 2009) MIS416, a novel microparticle-based immune response modifier, demonstrated the ability to significantly reduce the number and size of metastatic tumors in preclinical mouse models of lung and breast cancers, Innate Therapeutics (formerly Virionyx Corporation) announced. Research presented today at the American Association of Cancer Research (AACR) meeting in Denver, CO by researchers from the Auckland, NZ company and their colleagues at the David Geffen School for Medicine, University of California, Los Angeles showed that MIS416 significantly inhibited tumor growth and the formation of metastases when tested as a stand-alone agent. When administered as an adjunct to localized tumor irradiation, MIS416 also demonstrated synergistic activity against the recurrence of lung tumors. Moreover, in a therapeutic cancer vaccine model, MIS administered as a single agent significantly induced an anti-tumor cellular immune response without the reintroduction of previously harvested tumor antigens. This successful induction of adaptive immunity correlated with inhibition of tumor growth.

"On the basis of these findings, MIS416 appears to be a good candidate for clinical evaluation as an adjunct to existing cancer therapies such as surgery and radiation," said Gill Webster, Ph.D., chief scientific officer of Innate Therapeutics, who led the poster presentation. "In this clinical setting, MIS416 therapy may be able to contribute significantly towards limiting tumor reoccurrence or metastatic disease."

Immune response modifiers (IMRs) are agents that target the body's immune system to combat disease by mobilizing and expanding a broad range of intrinsic host defence mechanisms. Unlike first generation IMRs such as Toll-like receptor agonists or interferon alpha, each of which have a limited spectrum of activity and lack the ability to treat a broad range of malignant diseases, MIS416 acts on multiple pathways s
'/>"/>

Contact: Joan Kureczka
JKureczka@comcast.net
415-821-2413
Kureczka/Martin Associates
Source:Eurekalert

Page: 1 2

Related biology news :

1. Drug-embedded microparticles bolster heart function in animal studies
2. Device protects transplanted pancreatic cells from the immune system
3. Vitamin D may exacerbate autoimmune disease
4. New evidence explains poor infant immune response to certain vaccines, says MU researcher
5. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
6. A paradigm shift in immune response regulation
7. New origin found for a critical immune response
8. HIV adapts to escape immune response
9. Frogs immune system is key in fight against killer virus
10. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
11. Molecule that suppresses immune response under study in type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... Northridge, Calif. (October 16, 2014) – Post-menopausal women ... effect on hormone levels or genital bleeding, after ... of an investigational fermented soy germ-based nutritional supplement ... according to a new peer-reviewed pilot study reported ... Society (NAMS) annual scientific meeting. , "These ...
(Date:10/15/2014)... the pandemic risk from strains of influenza virus increases ... ourselves to become complacent that the most substantial threats ... , Influenza pandemics arise when a new virus strain ... immunity – spreads in the human population. There have ... the worst of which – the 1918 Spanish Flu ...
(Date:10/15/2014)... The Ebola virus is spreading rapidly and to an ... experienced in the past and the virus shows a ... been recorded before. For this reason, the German National ... of Science and Engineering, and the Union of the ... statement on the Ebola epidemic today. , In the ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... invites all journalists to attend its 64th Annual Scientific ... field of aging from November 18 to 22 ... charge. An estimated 3,500 professionals are expected to ... Veterans Memorial Convention Center and Sheraton Boston Hotel. The ...
... Later this week, the American Society of Plant Biologists (ASPB) ... to chart the future of the field. The Plant ... plant science research community in a process that will develop ... over the next decade. The summit will bring together ...
... researchers could help develop culturally appropriate conservation efforts and ... southwest China where deforestation is a major environmental issue. ... Religion and the Cultural Studies program, and An Jing, ... Studies, found a distinct link between the strong religious ...
Cached Biology News:Join GSA in Boston for the nation's premier aging conference 2ASPB convenes leaders to chart future of plant science research 2Religion and ecology among China's Blang people 2
(Date:10/22/2014)... San Diego, CA (PRWEB) October 22, 2014 ... laboratory balances from Sartorius, A & D Weighing, ... Sartorius CPA Semi-Micro Balance . The Sartorius ... looking for an affordable high-quality, precise, and user-friendly ... in manufacturing of laboratory equipment, their laboratory balances ...
(Date:10/22/2014)... October 22, 2014 According to ... by Service Type (Consulting, Integration, Deployment & Support), ... Deployment Model (Public, Private, Others (Hybrid & Community)) ... defines and segments the Cloud Professional Services Market ... forecasting of revenues. It also identifies the drivers ...
(Date:10/22/2014)... Oct. 22, 2014 Nuvilex, Inc. (OTCQB: NVLX) ... million people worldwide are living with diabetes, with  that ... 2030.  The global market for diabetes treatments is approximately ... people worldwide died from pancreatic cancer.  Pancreatic cancer is ... cancer in the United States , ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 The ... (Medication Dispensing Systems, Packaging and Labeling Systems, Table-top ... Automation) - Global Forecasts & Trends to 2019” ... and opportunities in North America, Europe, Asia-Pacific, and ... 101 market tables and 30 figures spread through ...
Breaking Biology Technology:Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
... 2011 Netsmart Technologies, Inc., a leading provider ... organizations nationwide, today announced an agreement with the ... for the provision of a comprehensive behavioral health ... be known as the Integrated Behavioral Health Information ...
... 1, 2011 Optimer Pharmaceuticals, Inc. (NASDAQ: ... at the 20th Annual Credit Suisse Healthcare Conference on ... AM Pacific Time). (Logo:   http://photos.prnewswire.com/prnh/20090413/LA97352LOGO ) ... will be accessible on the Investors page of the ...
... 2011 Elsevier, a world-leading provider of ... announced the availability of Elsevier Urban & Fischer ... life and health sciences, on SciVerse ScienceDirect . ... the renowned German imprint Urban & Fischer, contain journals ...
Cached Biology Technology:County of Los Angeles Selects Netsmart to Provide Comprehensive Behavioral Health Information System 2County of Los Angeles Selects Netsmart to Provide Comprehensive Behavioral Health Information System 3Elsevier Announces Availability of Urban & Fischer Journal Archives on SciVerse ScienceDirect 2
...
Recombinant Rat Leptin, CF...
Adhesive seal-tab, for HybriWell™ hybridization sealing system *set of 400*...
... cell culture systems provide an integrated ... staining and imaging. Each system uses ... optical-quality coverslips in cell culture plates. ... and ready to use. Individual chambered ...
Biology Products: