Navigation Links
Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer
Date:4/21/2009

DENVER, CO and AUCKLAND, NZ (April 21, 2009) MIS416, a novel microparticle-based immune response modifier, demonstrated the ability to significantly reduce the number and size of metastatic tumors in preclinical mouse models of lung and breast cancers, Innate Therapeutics (formerly Virionyx Corporation) announced. Research presented today at the American Association of Cancer Research (AACR) meeting in Denver, CO by researchers from the Auckland, NZ company and their colleagues at the David Geffen School for Medicine, University of California, Los Angeles showed that MIS416 significantly inhibited tumor growth and the formation of metastases when tested as a stand-alone agent. When administered as an adjunct to localized tumor irradiation, MIS416 also demonstrated synergistic activity against the recurrence of lung tumors. Moreover, in a therapeutic cancer vaccine model, MIS administered as a single agent significantly induced an anti-tumor cellular immune response without the reintroduction of previously harvested tumor antigens. This successful induction of adaptive immunity correlated with inhibition of tumor growth.

"On the basis of these findings, MIS416 appears to be a good candidate for clinical evaluation as an adjunct to existing cancer therapies such as surgery and radiation," said Gill Webster, Ph.D., chief scientific officer of Innate Therapeutics, who led the poster presentation. "In this clinical setting, MIS416 therapy may be able to contribute significantly towards limiting tumor reoccurrence or metastatic disease."

Immune response modifiers (IMRs) are agents that target the body's immune system to combat disease by mobilizing and expanding a broad range of intrinsic host defence mechanisms. Unlike first generation IMRs such as Toll-like receptor agonists or interferon alpha, each of which have a limited spectrum of activity and lack the ability to treat a broad range of malignant diseases, MIS416 acts on multiple pathways s
'/>"/>

Contact: Joan Kureczka
JKureczka@comcast.net
415-821-2413
Kureczka/Martin Associates
Source:Eurekalert

Page: 1 2

Related biology news :

1. Drug-embedded microparticles bolster heart function in animal studies
2. Device protects transplanted pancreatic cells from the immune system
3. Vitamin D may exacerbate autoimmune disease
4. New evidence explains poor infant immune response to certain vaccines, says MU researcher
5. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
6. A paradigm shift in immune response regulation
7. New origin found for a critical immune response
8. HIV adapts to escape immune response
9. Frogs immune system is key in fight against killer virus
10. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
11. Molecule that suppresses immune response under study in type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/17/2014)... 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend ... for medical sensors in biomedical applications. Chemical sensors ... and correct diagnosis during surgical procedures. The Global ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... Sept. 30, 2011 -- Molecular motion in proteins ... collaboration by researchers at the Department of Energy,s ... Tennessee, in research reported in Physical Review Letters. ... Governor,s Chairs Jeremy Smith and Alexei Sokolov, combined ...
... in the October issue of The American Naturalist ... with the help of the same phenomenon that fogs up ... Darwin University in Australia, tree frogs often plop themselves down ... Australia. When they return to their dens, condensation forms on ...
... the diaphragm muscles has received approval from the Food and ... Sclerosis (ALS), also known as Lou Gehrig,s disease. The ... patients breathe longer without the aid of a ventilator. ... Medical Center who helped develop and test DPS and who ...
Cached Biology News:High-performance simulation, neutrons uncover 3 classes of protein motion 2Tree frogs chill out to collect precious water 2Diaphragm pacing system receives FDA approval for use with ALS patients 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Lucigen Corporation has been awarded the maximum $250,000 ... a special SBIR grant program for its enzyme research. ... products and technologies with high potential value. , ,Under ... raised by Lucigen from outside investors. , ,The award ...
... For small businesses, sometimes getting the company name out ... is working to help these fledglings utilize the ... marketing company Constant Contact, Business Filings will now provide ... new customers. Constant Contact's clientele will also have access ...
... solution , ,ROCHESTER, Wis. Runzheimer ... announced Monday the formation of an exclusive partnership ... information to travel managers within the Concur Expense ... firm specializing in travel programs, policy and cost ...
Cached Biology Technology:Small businesses to benefit from Business Filings partnership 2Runzheimer and Concur develop travel management service 2
... Model SPD131DDA , Our most chemically resistant ... to handle the rigors and solvents of Combinatorial ... display, dual independent timers, an automatic bleeder valve ... pathway. , , Adjustable Vacuum Level ...
... a dedicated concentrator for efficient drying of ... The integrated system combines the SpeedVac™ Concentrator ... design, automatic pump and rotor control, and ... for heater time), makes the DNA120 indispensable ...
... George Paxinos Affiliation: School of Psychology, The ... Watson Affiliation: Curtin University of Technology, Perth, Australia ... atlas of the rat brain. It is ... mm) revison and extension of the compact 3rd ...
For absolute protein quantification. 4 peptides in 5 vials x 2 nmol per peptide...
Biology Products: