Navigation Links
Microfluidic platform gives a clear look at a crucial step in cancer metastasis
Date:9/20/2013

ears to heal itself, closing the gaps that the cell initially created. "That suggests that the endothelial barrier has some kind of active role in repairing itself after this invasion by the tumor cell," Chen says.

In addition to observing the extravasation of single tumor cells, the group also looked at the behavior of cell clusters -- two or more cancer cells that accumulate in a blood vessel. From their observations, the researchers found that almost 70 percent of cell clusters broke through a blood barrier, compared with less than 10 percent of single cells.

But some cells that make it out of the circulatory system may still fail to metastasize. To see whether a cell's ability to extravasate correlates with its metastatic potential, the group compared the efficiency of extravasation of different cancer cell lines. The lines included breast cancer cells, cells from fibrosarcoma (a cancer of the connective tissue), and a line of nonmetastatic cancer cells.

Sure enough, the team observed that the most metastatic cells (fibrosarcoma cells) were also the most likely to extravasate, compared with breast cancer and nonmetastatic cells -- a finding suggesting that targeting drugs to prevent extravasation may slow cancer metastasis.

Going forward, the group is looking into how likely a given cancer cell is to proliferate and aggregate with others once it has exited into the surrounding tissue. The researchers are modeling various tissues within the microfluidic platform, including bone, to study how cancer cells form the beginnings of a secondary tumor.

"Although this platform isn't an in-vivo platform and obviously can't capture all the aspects that happen in vivo, we've come a lot closer to creating an in-vitro platform that's even more physiologically relevant, high-resolution and high-throughput than a lot of previous platforms," Chen says.


'/>"/>

Contact: Andrew Carleen
acarleen@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UT Arlington engineer wins NSF award to support microfluidic analyses of tissue, cell samples
2. Engineers use droplet microfluidics to create glucose-sensing microbeads
3. LaserLock Technologies Files A New Provisional Patent Which Secures Player Identity On Internet Gaming Platforms
4. BluStor Introduces the Worlds First Platform to Protect the Full Stream of Mobile Security: Device, User, And Data
5. Pensoft Publishers integrate their journal platform with OpenAIRE
6. Surgical Theater, LLC sells first Surgical Rehearsal Platform to UH Case Medical Center
7. GEOLOGY speeding top science to online platform
8. BioFortis Inc., Introduces Next Generation Biobanking Software Platform for Biomarker-Based Clinical Research
9. HubSpot Certifies TREW Marketing for Integrated Marketing Platform
10. BGI Tech and BAB jointly develop transgenic mice platform for biomedical research
11. A drug-screening platform for ALS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... test provides a fast and accurate tool to ... shows. The newly developed test (TAM-TB assay) is ... tuberculosis in children. The test features excellent specificity, ... with speed of a blood test. The promising ... of tuberculosis in children, particularly in tuberculosis-endemic regions. ...
(Date:8/31/2014)... Nature Climate Change , suggests that if current trends ... the global targets for total greenhouse gas (GHG) emissions in ... think carefully about the food we choose and its environmental ... just one of a number of actions that need to ... is enough food for all. , As populations rise ...
(Date:8/29/2014)... recently, little has been known about what genetic changes ... of scientists, one of whom is a University of ... that genes controlling the development of the brain and ... The study was published Aug. 28 in Science ... is online at http://www.sciencemag.org/ ., The domestication of ...
Breaking Biology News(10 mins):New tuberculosis blood test in children is reliable and highly specific 2Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3
... of novel marine microbes could lead to more efficient ... such as epilepsy, diabetes, flu and other viruses, as ... as agrochemicals. Researchers at Heriot-Watt University and Plymouth ... Ingenza Ltd are searching for new enzymes for use ...
... associated diseases cost pig producers around the world hundreds ... Kansas State University virologists Dick Hesse and Bob Rowland ... such complex diseases. "Circovirus and its associated diseases ... porcine reproductive and respiratory syndrome and circovirus are a ...
... Banks National Marine Sanctuary is among the healthiest coral ... Mexico, according to a new NOAA report. The ... Benthic Habitats within the Flower Garden Banks National Marine ... within the sanctuary based on data collected in 2006 ...
Cached Biology News:Marine microbes creating green waves in industry 2Marine microbes creating green waves in industry 3K-State lab gives researchers the tools to study porcine circovirus associated diseases 2NOAA report finds flower garden banks sanctuary reefs among healthiest in Gulf 2
(Date:9/1/2014)... NEW YORK , Sept. 1, 2014 /PRNewswire/ ... report is available in its catalogue: ... Opportunities, 2019 http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html ... municipal corporations are the main governing bodies responsible ... management in cities. On an average, around 135,000 ...
(Date:8/31/2014)... September 01, 2014 Available spectra ... needs for research and cultivation of a wide ... Valoya’s proprietary LEDs with proven patented and pending ... uncompromised light uniformity in critical applications in contrast ... LEDs. , “Our customers have a large variety ...
(Date:8/29/2014)... 2014  Pfenex Inc. (NYSE MKT: PFNX), a ... high-value and difficult to manufacture proteins including biosimilar ... financial results for the second quarter ended June ... of our initial public offering, we have the ... candidates, derived from our proprietary protein expression platform," ...
(Date:8/29/2014)... Pittsburgh, PA (PRWEB) August 29, 2014 ... Chairman, Hub MacDonald, and colleague Koichiro Matsuda, Horiba Scientific, ... JASIS on September 5, 2014. JASIS , Asia’s ... September 3-5, 2014, in Makuhari Messe, Japan. , ... New Tools for Bioanalysis from Single Molecules to Single ...
Breaking Biology Technology:India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2
... 63 unique dust particles from their laboratory and that,s ... new kind of sensor when dust got stuck inside it, ... single dust particles. In a recent issue of The ... the discovery could aid the study respiratory diseases caused by ...
... 2011 Professor Ian Phillips of Keck Graduate Institute (KGI) ... patent for a novel procedure that involves stem cells in ... covers a two-step process developed by Phillips and Yao Liang ... of pure stem cells for transplantation into the heart or ...
... Oct. 5, 2011 A recent survey of California,s ... great potential for job growth in the state. ... percent in the past five years, according to a ... industry associations in the state, and Radford, a compensation ...
Cached Biology Technology:1 room -- 63 different dust particles? Researchers aim to build dust library 21 room -- 63 different dust particles? Researchers aim to build dust library 3KGI Professor Awarded Patent for Stem-Cell Therapy Aiding Heart-attack Patients 2California's Industrial Biotechnology Workforce: Creating Jobs and Leading Innovation 2California's Industrial Biotechnology Workforce: Creating Jobs and Leading Innovation 3
Homo sapiens similar to Cytosolic acyl coenzyme A thioester hydrolase Antigen: Peptide...
96 Well Base Plate...
... Inhibitor is a potent noncompetitive ... as RNase A. Like other ... Inhibitor is an acidic protein ... kDa. RNaseOUT inhibits RNase A ...
... and Recombinant RNasin Ribonuclease Inhibitors have broad ... of eukaryotic RNases of the neutral type ... effect by noncovalently binding to RNases in ... the binding of RNasin Ribonuclease Inhibitor to ...
Biology Products: