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Microchip reveals how tumor cells transition to invasion
Date:8/17/2014

, they found that the cells that stayed with the group started to once again express the epithelial proteins, indicating that they had reverted back to the epithelial cell type.

"That was a remarkable result," Wong said. "Based on these results, an interesting therapeutic strategy might be to develop drugs that downgrade mesenchymal sports cars back to epithelial economy models in order to keep them stuck in traffic, rather than aggressively invading surrounding tissues."

As for the technology that made these findings possible, the researchers are hopeful that it can be used for further research and drug testing.

"We envision that this technology will be widely applicable for preclinical testing of anti-migration drugs against many different cancer cell lines or patient samples," Wong said.


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Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University
Source:Eurekalert  

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