Navigation Links
Microbubble-delivered combination therapy eradicates prostate cancer in vivo
Date:5/10/2011

Richmond, Va. (May 10, 2011) Cancer researchers are a step closer to finding a cure for advanced prostate cancer after effectively combining an anti-cancer drug with a viral gene therapy in vivo using novel ultrasound-targeted microbubble-destruction (UTMD) technology. The research was conducted by scientists at Virginia Commonwealth University Massey Cancer Center, VCU Institute of Molecular Medicine and School of Medicine, in collaboration with colleagues from Washington University School of Medicine and Sanford-Burnham Medical Research Institute.

In their study, published in the journal Proceedings of the National Academy of Sciences, prostate cancer growth in mice with functioning immune systems was inhibited by sensitizing the cancer cells with the drug Sabutoclax (BI-97C1) and using UTMD technology to deliver a viral gene therapy that expresses the gene mda-7/IL-24. This powerful new approach to treating prostate cancer builds upon prior studies by principle investigator Paul B. Fisher, M.Ph., Ph.D., Thelma Newmeyer Corman Endowed Chair at VCU Massey, professor and chair of the Department of Human and Molecular Genetics in the VCU School of Medicine and director of the VCU Institute of Molecular Medicine.

Sabutoclax works by inhibiting the protein Mcl-1, which is known to promote cell survival by preventing a form of cell suicide known as apoptosis. Fisher's laboratory studies previously showed that the gene mda-7/IL-24 increases apoptosis in tumor cells, prevents tumor growth and blood vessel formation, synergizes with other cancer treatments and also regulates cellular immune responses while having no ill effects on normal, healthy cells. By showing the combined effectiveness of these agents, the researchers have discovered a novel treatment approach for prostate cancer.

"Successful execution of viral gene therapy is typically limited by the body's natural defenses, such as trapping the virus in the liver and attacking the virus with its n
'/>"/>

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Combination therapy provides hope for cure of dangerous infections of cystic fibrosis patients
2. Killing drug-resistant melanoma requires combination therapy
3. Combination therapy reduced HER2-positive breast cancers
4. Pertuzumab and trastuzumab combination improved efficacy for women with HER2-positive breast cancer
5. Novocure reports data showing TTF therapy in combination with chemotherapy has the potential to increase overall survival for patients with advanced non-small cell lung cancer
6. Grape news: New treatment combination safe alternative to sulfur dioxide
7. Study: Grass, fungus combination affects ecology
8. Investigators identify cleat/natural grass combination may be less likely to result in ACL injury
9. Diabetes drug kills cancer stem cells in combination treatment in mice
10. Old stain in a new combination
11. Latest advances in gene therapy for ocular disease are highlighted in Human Gene Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Profile Solutions, Inc. (OTC: PSIQ), a leading ... pleased to announce that Dr Gerry Bedore ... of its scientific advisory board. ... leader in technology-enhanced learning models. He was a co-founder ... studies and books focused on online student success and ...
(Date:4/20/2015)... 20, 2015 The announcement comes ... Glenbeigh Records Management (GRM), Ireland,s foremost ... Bank. Having built up an impressive track record of clients ... player within the records management sector in Dubai ... is GCC staffbase and employ a further eight staff members ...
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Institute of Technology (Caltech) have trained computers to automatically ... way for researchers to perform large-scale, high-throughput screens for ... computers to examine half an hour of video footage ... real time; characterizing the behavior of a new line ...
... controls the rapid production and differentiation of the stem ... discovery that could eventually open the door to more ... which blood cells proliferate out of control. ... scientists uncovered evidence that could lead to a protocol ...
... If cancer cells lack a certain protein, it could ... tissue, the first step towards forming metastases. Scientists at ... discovered the previously unknown cell signal factor SCAI (suppressor ... spread of tumor cells in laboratory tests. When the ...
Cached Biology News:Caltech researchers train computers to analyze fruit-fly behavior 2Caltech researchers train computers to analyze fruit-fly behavior 3Scientists identify key gene that protects against leukemia 2Scientists identify key gene that protects against leukemia 3How tumor cells move 2
(Date:5/29/2015)... 2015 In recent years, the biopharmaceutical industry ... Data that can generate valuable insights. Despite this, the ... Data have caused the biopharmaceutical sector to embrace Big ... According to a recent study by benchmarking firm, ... Big Data team or function in place; however, these ...
(Date:5/29/2015)... May 29, 2015 The Academy of ... thirteen high school graduates from across the nation. , ... to award qualified AMA Youth Members with scholarships to ... AMA Scholarship Program has awarded nearly $900,000 to college-bound ... model aviation organizations and individuals, AMA member donations, a ...
(Date:5/29/2015)... NEW YORK , May 29, 2015 /PRNewswire/ ... a specialty pharmaceutical and medical device company focused ... of primary and metastatic liver cancers, announces that ... the treatment of uveal melanoma patients with hepatic ... Delivery System, were highlighted in an on-line abstract ...
(Date:5/29/2015)...  Caris Life Sciences ® , a leading ... precision medicine, today announced the presentation of data ... of Caris Molecular Intelligence ® , the company,s ... identify targeted treatment options for patients with rare ... results of which are to be presented in ...
Breaking Biology Technology:New Study Details Current & Future Big Data Trends Across Medical Affairs Functions 2Academy of Model Aeronautics Awards $46,500 in Scholarships to College-Bound Model Aviation Pilots 2Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 2Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 3Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 4Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 3Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 4Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 6
... in Germany ... ... lpUnit=,PRN,; --> ... s = ,; var first_result; // Results are keyed by longUrl, so we need to grab the first ...
... demonstrated a new imaging tool for rapidly screening ... use in creating a new class of computers ... power than today,s. The semiconducting nanostructures might ... silicon components and circuits. However, one obstacle in ...
... Corporation acquires Toronto start-up CognoVision ... ... --> ... var first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var r ...
Cached Biology Technology:Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany 2Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany 3Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany 4Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany 5Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany 6Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany 7Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany 8Aeterna Zentaris Presents Encouraging Preclinical Data on Two Novel Orally Active Anti-Cancer Compounds at Major Conference in Germany 9Imaging tool may aid nanoelectronics by screening tiny tubes 2Imaging tool may aid nanoelectronics by screening tiny tubes 3Intel Corporation acquires Toronto start-up CognoVision 2Intel Corporation acquires Toronto start-up CognoVision 3Intel Corporation acquires Toronto start-up CognoVision 4Intel Corporation acquires Toronto start-up CognoVision 5Intel Corporation acquires Toronto start-up CognoVision 6Intel Corporation acquires Toronto start-up CognoVision 7
... Purity is >95%NEN Radiolabeled Ligands\n\nReceptor-related research has ... of new radiolabeled ligands selected to keep ... wide range of products and services for ... 400 state-of-the-art radioligands. If you do not ...
...
... Bioluminescence assay for monitoring acetylcholinesterase (AChE) activity. ... (less than 5 min), non-radioactive and easy ... uses the natural substrate, acetylcholine. A series ... of active AChE into a change in ...
... RTS AviTag E. coli Biotinylation Kit, Linear Template ... E. coli expression kits. (Cat. No. 3 186 ... to rapidly generate linear expression constructs by PCR ... on a combination of T7 RNA polymerase and ...
Biology Products: