Navigation Links
Microbiologists find defense molecule that senses respiratory viruses
Date:8/23/2009

SAN ANTONIO, Texas, U.S.A. A cellular molecule that not only can sense two common respiratory viruses but also can direct cells to mount a defense has been identified by microbiologists at The University of Texas Health Science Center at San Antonio.

The finding, published online Sunday, Aug. 23, by the journal Nature Immunology, could lead to new therapies for human respiratory syncytial virus (RSV) and influenza A (commonly known as flu), both of which are serious threats to people with weak immune systems, particularly infants up to age 1 and senior citizens age 65 and older.

"This molecule could be used to boost host immune defenses and stimulate vaccine efficacy against RSV and influenza A, especially among high-risk individuals," said senior author Santanu Bose, Ph.D., assistant professor of microbiology and immunology. Dr. Bose's laboratory team includes graduate student Ahmed Sabbath and research scientists Te-Hung Chang and Rosalinda Harnack.

Related to survival

The cellular molecule, called NOD2, recognizes these viruses and can instruct cells to defend against them. Researchers found that mice lacking the sensor survive for only 10 days after infection, compared with up to eight weeks for normal animals.

Identifying this sensor and understanding its key role could result in therapies that activate the NOD2 gene during or prior to infection, leading to enhanced protective immunity. The NOD2 sensor also has the potential to recognize other viruses, such as West Nile virus, yellow fever, Ebola and rabies.

Dr. Bose has multiple grants from the National Institutes of Health and the American Lung Association to continue this line of research. "In the future, studies will gear up to find out if NOD2 is a susceptibility gene for respiratory viruses, since frequent mutation of this gene has been found in humans," he said.

Possible clinical use

Once the study is designed and clinical partner affiliations are reached, the Bose team hopes to draw blood from severely infected, moderately infected and non-infected patients to test for levels of the sensor, which would allow predictions as to how individuals might respond to respiratory viral infections.

"This is a major breakthrough in understanding respiratory virus behavior and innate immune antiviral factors, and provides the basis for innovative therapies to improve host responses to infectious diseases," said Joel Baseman, Ph.D., professor and chairman of microbiology and immunology at the Health Science Center.

Dr. Baseman said microbiology and immunology faculty members in the university's Graduate School of Biomedical Sciences are doing fundamental and translational research that is the basis for the establishment of an airway disease research and vaccine center. The group includes Dr. Bose's co-authors on the NOD2 paper, Peter Dube, Ph.D., and Yan Xiang, Ph.D.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Related biology news :

1. Early detection and quick response are key to defense against anthrax attack
2. New discovery suggests trees evolved camouflage defense against long extinct predator
3. Sex involved in plant defense
4. Supply Chain Council Seminar Focuses on Defense and IT
5. Supply Chain Council Seminar Focuses on Defense and IT
6. Researchers discover primer to plant defense system
7. Reforming defense department acquisition policy: UM expert
8. Understanding natural crop defenses
9. CSC Awarded Department of Defense Biometrics Contract
10. SectorWatch.biz Issues Commentary for Investors of Homeland Defense Companies FOUR, MAGS, NSSC, PNTR, BCO, and CKP
11. ASM biodefense and emerging diseases research meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Microbiologists find defense molecule that senses respiratory viruses
(Date:2/11/2016)... , Feb. 11, 2016  According to new research ... mainstream. More than 200 fingerprint, iris, and eye-vein ... under 70 brand names. This includes market leaders ... ZTE. Acuity projects that 600 million biometric smartphones ... global installed base. Maxine Most , ...
(Date:2/11/2016)... Feb. 11, 2016  Vigilant Solutions announces today that its ... being used by Lee,s Summit Police ... location and arrest of a homicide suspect. ... covers around 65 square miles and is home to roughly ... has a single mobile license plate reader system and also ...
(Date:2/10/2016)... February 10, 2016 ... to 2016 iris recognition market report, combined ... is more widely accepted for border control. ... fingerprint and iris recognition technology in a ... avoid purchasing two individual biometrics devices. ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... ATLANTA , Feb. 11, 2016  Wellcentive ... a Portland, Oregon -based community ... to provide population health analytics, quality reporting and ... help FamilyCare strengthen its team of quality managers, ... reporting to the provider groups serving FamilyCare members. ...
(Date:2/11/2016)... BioInformant announces the February 2016 release of its ... and Technologies – Market Size, Segments, Trends, and Projections ... The first and only market research firm ... more than a decade of historical information on all ... type. This powerful 175 page global strategic report contains ...
(Date:2/10/2016)... /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), a ... Mitsui & Co. Ltd., its partner in the ... investing an additional CDN$25 million in the joint venture ... 30% to 40%.  Mitsui will also play a stronger ... Sarnia , providing dedicated resources alongside ...
(Date:2/10/2016)... is introducing a hybrid membership model which will provide ... joining or renewing through an organizational purchasing model. For ... employee in any size association or AMC office can ... benefits.   John H. Graham, IV , ... organizations of any size and their employees to gain ...
Breaking Biology Technology: