Navigation Links
Microbiologists find defense molecule that senses respiratory viruses
Date:8/23/2009

SAN ANTONIO, Texas, U.S.A. A cellular molecule that not only can sense two common respiratory viruses but also can direct cells to mount a defense has been identified by microbiologists at The University of Texas Health Science Center at San Antonio.

The finding, published online Sunday, Aug. 23, by the journal Nature Immunology, could lead to new therapies for human respiratory syncytial virus (RSV) and influenza A (commonly known as flu), both of which are serious threats to people with weak immune systems, particularly infants up to age 1 and senior citizens age 65 and older.

"This molecule could be used to boost host immune defenses and stimulate vaccine efficacy against RSV and influenza A, especially among high-risk individuals," said senior author Santanu Bose, Ph.D., assistant professor of microbiology and immunology. Dr. Bose's laboratory team includes graduate student Ahmed Sabbath and research scientists Te-Hung Chang and Rosalinda Harnack.

Related to survival

The cellular molecule, called NOD2, recognizes these viruses and can instruct cells to defend against them. Researchers found that mice lacking the sensor survive for only 10 days after infection, compared with up to eight weeks for normal animals.

Identifying this sensor and understanding its key role could result in therapies that activate the NOD2 gene during or prior to infection, leading to enhanced protective immunity. The NOD2 sensor also has the potential to recognize other viruses, such as West Nile virus, yellow fever, Ebola and rabies.

Dr. Bose has multiple grants from the National Institutes of Health and the American Lung Association to continue this line of research. "In the future, studies will gear up to find out if NOD2 is a susceptibility gene for respiratory viruses, since frequent mutation of this gene has been found in humans," he said.

Possible clinical use

Once the study is
'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Early detection and quick response are key to defense against anthrax attack
2. New discovery suggests trees evolved camouflage defense against long extinct predator
3. Sex involved in plant defense
4. Supply Chain Council Seminar Focuses on Defense and IT
5. Supply Chain Council Seminar Focuses on Defense and IT
6. Researchers discover primer to plant defense system
7. Reforming defense department acquisition policy: UM expert
8. Understanding natural crop defenses
9. CSC Awarded Department of Defense Biometrics Contract
10. SectorWatch.biz Issues Commentary for Investors of Homeland Defense Companies FOUR, MAGS, NSSC, PNTR, BCO, and CKP
11. ASM biodefense and emerging diseases research meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Microbiologists find defense molecule that senses respiratory viruses
(Date:12/17/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first ... The Galaxy S5 home button presents an ...
(Date:12/17/2014)... DENVER , Dec. 16, 2014  Automation ... is this more evident than at international borders. ... secure document scanners have allowed veteran travelers to ... Automated Passport Control (APC) Kiosks at an increasing ... the globe. According to ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... at a pro-inflammatory signaling molecule involved in immune ... what they are doing" in creating drugs based ... in the Oct. 1 issue of the Journal ... at Urbana-Champaign unveiled the crystal structure of mouse ...
... project website , The annual Educational Technology ... been granted to the project 'Virtual microscopy as a ... the university. The awarded project utilizes advanced digital imaging ... specimens over the internet. , 'Virtual specimens' incorporated ...
... additional insight into the evolutionary process by examining ... New York University Biology Professor Richard Borowsky, examined ... albinism in both populations was linked to Oca2--a ... form of albinism in humans. They observed different ...
Cached Biology News:Molecular research suggest shift needed in how some drugs are created 2Genetic analysis of cavefish reveals more about evolution 2
(Date:12/19/2014)...   ISN has released its third annual ... publication series. With data aggregated from over eight ... within its online contractor management platform, ISNetworld, this three-part ... (KPI) statistics. The Contractor ... is available in two industry specific volumes: Oil ...
(Date:12/17/2014)... December 17, 2014 Based on ... overall surgical imaging market is dominated by four ... surgical imaging market. These players include GE Healthcare ... Imaging (Germany). , Full Report Copy at ... GE Healthcare can be attributed to its strong ...
(Date:12/17/2014)... 17, 2014 Ipsen Biopharmaceuticals, Inc., ... ADR: IPSEY), today announced that Somatuline® ... Somatuline®) was approved by the U.S. Food and ... neuroendocrine tumors (GEP-NETs) in adult patients with unresectable, ... disease to improve progression-free survival (PFS). , “The ...
(Date:12/17/2014)... Xeno Diagnostics has again received an ... COLA inspection. Xeno has met all criteria for ... organization. Accreditation is earned only by laboratories that ... demonstrate continued accuracy in the performance of proficiency ... , While the Laboratory Excellence award ...
Breaking Biology Technology:ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
... JACKSONVILLE, Fla., Oct. 4, 2011 MSC Care ... and services to post-discharge and post-injury workers, compensation ... Integrated Healthcare Services, a national company also focused ... unique and comprehensive surgical implant cost management solution, ...
... NeoStem, Inc. (NYSE Amex: NBS ) ("NeoStem" ... on cell-based therapeutic development, today announced that the Company and ... at three upcoming October conferences: the 2011 World Stem Cell ... Bioprocessing. 2011 World Stem Cell Summit ...
... Sequenom, Inc. (NASDAQ: SQNM ), a ... announced the launch of its iPLEX ADME PGx panel ... absorption, distribution, metabolism, and excretion (ADME). This Research Use ... nucleotide polymorphisms (SNP), insertions and deletions (INDELS) and copy ...
Cached Biology Technology:MSC to Offer Surgical Implant Cost Management Solution through Acquisition of Integrated Healthcare Services 2NeoStem Announces Participation in Multiple October Conferences 2NeoStem Announces Participation in Multiple October Conferences 3NeoStem Announces Participation in Multiple October Conferences 4Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 3
Rat Dermal Fibroblasts (RDF) (>500,000 cells)...
...
... System is a compact, versatile & modular instrument ... purposes including: Intracellular, Extracellular, Transducer & Multi-channel ... NeuroLog Case & Power Supply unit (NL900D) forms ... are not only powered by this unit, but ...
37-1A9...
Biology Products: