Navigation Links
Microbiologists find defense molecule that senses respiratory viruses
Date:8/23/2009

SAN ANTONIO, Texas, U.S.A. A cellular molecule that not only can sense two common respiratory viruses but also can direct cells to mount a defense has been identified by microbiologists at The University of Texas Health Science Center at San Antonio.

The finding, published online Sunday, Aug. 23, by the journal Nature Immunology, could lead to new therapies for human respiratory syncytial virus (RSV) and influenza A (commonly known as flu), both of which are serious threats to people with weak immune systems, particularly infants up to age 1 and senior citizens age 65 and older.

"This molecule could be used to boost host immune defenses and stimulate vaccine efficacy against RSV and influenza A, especially among high-risk individuals," said senior author Santanu Bose, Ph.D., assistant professor of microbiology and immunology. Dr. Bose's laboratory team includes graduate student Ahmed Sabbath and research scientists Te-Hung Chang and Rosalinda Harnack.

Related to survival

The cellular molecule, called NOD2, recognizes these viruses and can instruct cells to defend against them. Researchers found that mice lacking the sensor survive for only 10 days after infection, compared with up to eight weeks for normal animals.

Identifying this sensor and understanding its key role could result in therapies that activate the NOD2 gene during or prior to infection, leading to enhanced protective immunity. The NOD2 sensor also has the potential to recognize other viruses, such as West Nile virus, yellow fever, Ebola and rabies.

Dr. Bose has multiple grants from the National Institutes of Health and the American Lung Association to continue this line of research. "In the future, studies will gear up to find out if NOD2 is a susceptibility gene for respiratory viruses, since frequent mutation of this gene has been found in humans," he said.

Possible clinical use

Once the study is designed and clinical partner affiliations are reached, the Bose team hopes to draw blood from severely infected, moderately infected and non-infected patients to test for levels of the sensor, which would allow predictions as to how individuals might respond to respiratory viral infections.

"This is a major breakthrough in understanding respiratory virus behavior and innate immune antiviral factors, and provides the basis for innovative therapies to improve host responses to infectious diseases," said Joel Baseman, Ph.D., professor and chairman of microbiology and immunology at the Health Science Center.

Dr. Baseman said microbiology and immunology faculty members in the university's Graduate School of Biomedical Sciences are doing fundamental and translational research that is the basis for the establishment of an airway disease research and vaccine center. The group includes Dr. Bose's co-authors on the NOD2 paper, Peter Dube, Ph.D., and Yan Xiang, Ph.D.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Related biology news :

1. Early detection and quick response are key to defense against anthrax attack
2. New discovery suggests trees evolved camouflage defense against long extinct predator
3. Sex involved in plant defense
4. Supply Chain Council Seminar Focuses on Defense and IT
5. Supply Chain Council Seminar Focuses on Defense and IT
6. Researchers discover primer to plant defense system
7. Reforming defense department acquisition policy: UM expert
8. Understanding natural crop defenses
9. CSC Awarded Department of Defense Biometrics Contract
10. SectorWatch.biz Issues Commentary for Investors of Homeland Defense Companies FOUR, MAGS, NSSC, PNTR, BCO, and CKP
11. ASM biodefense and emerging diseases research meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Microbiologists find defense molecule that senses respiratory viruses
(Date:2/8/2017)... 2017 Report Highlights The global ... $8.3 billion in 2016 at a compound annual growth ... Report Includes - An overview of the global market ... data from 2015 and 2016, and projections of compound ... the market on the basis of product type, source, ...
(Date:2/6/2017)... Feb. 6, 2017 According to Acuity ... driving border authorities to continue to embrace biometric ... are 2143 Automated Border Control (ABC) eGates and ... at more than 163 ports of entry across ... 2016 achieving a combined CAGR of 37%. APC ...
(Date:2/2/2017)... , Feb. 2, 2017  EyeLock LLC, a ... a new white paper " What You Should Know ... problem of ensuring user authenticity is a growing concern. ... authentication of users. However, traditional authentication schemes such as ... Biometric authentication offers an elegant solution to ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... , Feb. 16, 2017  ArmaGen, Inc., ... groundbreaking therapies to treat severe neurological disorders, today ... treated with AGT-181, the company,s investigational therapy for ... known as mucopolysaccharidosis type I, or MPS I). ... proof-of-concept (POC) study, presented today at the 13 ...
(Date:2/16/2017)... , Feb. 16, 2017   Biostage, Inc. ... "Company"), a biotechnology company developing bioengineered organ implants to ... bronchus and trachea, announced today the closing on February ... 20,000,000 shares of common stock and warrants to purchase ... of $8.0 million. The offering was priced at $0.40 ...
(Date:2/16/2017)...  Dermata Therapeutics, LLC, a biotechnology company developing ... of dermatological diseases, today announced it has completed ... into a $5 million credit facility with Silicon ... capital for general corporate purposes to further Dermata,s ... of serious diseases treated by dermatologists.   ...
(Date:2/16/2017)... 2017  Windtree Therapeutics, Inc. (Nasdaq: ... aerosolized KL4 surfactant therapies for respiratory diseases, announced ... showed that aerosolized KL4 surfactant reduced lung inflammation ... animal model. The Company believes that these preclinical ... that supports the role of KL4 surfactant as ...
Breaking Biology Technology: