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Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
Date:10/15/2007

preparation methods by providing an adaptable, massively parallel method for selective enrichment of genomic regions of interest. Roche NimbleGens sequence capture technology enables high-performance targeting of thousands of specific genes or loci using a single microarray hybridization-based enrichment process. The Baylor study1 used Roches Genome Sequencer FLX System to quickly and affordably sequence the enriched genomic regions for downstream analysis. 454 Sequencing technology is ideal for this targeted sequencing approach because of its long read lengths and highly accurate reads.

This new technology will replace polymerase chain reaction (PCR) for many purposes, said Gibbs. If the aim is to sequence a whole genome for everybody, this is a huge step in that direction.

The Nature Methods paper published by Baylor1 demonstrates that the sequence capture process is simpler, more accurate, more efficient and more cost-effective than the multiplex PCR that was previously used to prepare genomic samples for sequencing. In one experiment, more than 6,700 exons (the part of the genetic code that together form genes), were enriched and analyzed, as well as contiguous genomic regions of up to 5 million bases. Using the old technology this would have taken at least six months.

"Were delighted to have an opportunity to collaborate with scientists at Baylor HGSC on the development of this breakthrough technology," said Dr. Stan Rose, President of Roche NimbleGen. "The combination of these two Roche technologiesNimbleGen and 454has the potential to transform the market for DNA sequence analysis."


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Contact: Joleen Rau
jrau@nimblegen.com
608-218-7623
Russo Partners, LLC
Source:Eurekalert

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