CHAMPAIGN, Ill. Whenever it hears an unfamiliar song from a bird of the same species, a zebra finch stops chirping, hopping and grooming. It listens attentively for minutes at a time, occasionally cocking its head but otherwise immobile. Once it becomes familiar with the song, it goes back to its busy routine. (See video.)
In a new study, researchers discovered that levels of microRNAs short lengths of ribonucleic acid that appear to regulate protein production go up or down in the songbird brain after it hears a new song. These microRNAs likely represent a new class of regulatory agents that fine-tune the brain's response to social information, said University of Illinois cell and developmental biology professor David Clayton, who led the study.
MicroRNAs are part of a new frontier in genomic biology: the 90 percent of human DNA that doesn't code for proteins. This "dark matter of the genome" includes genes that are transcribed into many different types of RNA molecules. Scientists are still working to decipher their various structures and functions.
Previous studies found that brain microRNAs "undergo dramatic changes in expression during development and aging and have been functionally implicated in neurological disease," the authors wrote in their paper in BMC Genomics. MicroRNAs appear to regulate the expression of protein-coding genes by binding to messenger RNA (mRNA) transcripts, the blueprints for proteins, before they can be translated into proteins.
Clayton and other researchers have documented changes in the expression of many mRNAs in the songbird brain after it hears an unfamiliar song. But no studies have, until now, found evidence that microRNAs also contribute to the process by which the br
|Contact: Diana Yates|
University of Illinois at Urbana-Champaign