Navigation Links
MicroRNAs help control HIV life cycle
Date:6/25/2009

LA JOLLA, Calif., June 26, 2009 Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role in controlling the HIV life cycle. The study suggests that HIV may have co-opted this cellular defense mechanism to help the virus hide from the immune system and antiviral drugs. The research was published today in the journal Molecular Cell.

Tariq Rana, Ph.D., director of the Program for RNA Biology at Burnham, and colleagues, found that the microRNA miR29 suppresses translation of the HIV-1 genome by transporting the HIV mRNA to processing-bodies (P-bodies), where they are stored or destroyed. This results in a reduction of viral replication and infectivity. The study also showed that inhibition of miR29 enhances viral replication and infectivity. The scientists further demonstrated that strains of HIV-1 with mutations in the region of the genome that interact with miR29 are not inhibited by miR29.

"We think the virus may use this mechanism to modulate its own lifecycle, and we may be able to use this to our advantage in developing new drugs for HIV," said Dr. Rana. "Retroviral therapies greatly reduce viral load but cannot entirely eliminate it. This interaction between HIV and miR29 may contribute to that inability. Perhaps, by targeting miR29, we can force HIV into a more active state and improve our ability to eliminate it."

Rana's team looked at miR29 expression levels in infected and uninfected cells and found that miR29 expression was enhanced by HIV-1 infection. Blocking the activity of miR29 with interfering RNA resulted in increased replication and infectivity of the virus. The scientists tested the association of miR29 and HIV-1 by mutating both miR29 and its target region on the HIV virus. When either was altered, miR29s suppression
'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

2

GOOD

Page: 1 2

Related biology news :

1. MicroRNAs grease the cells circadian clockwork
2. Mass. Generals Warren Triennial Prize honors discoverers of microRNAs
3. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
4. Making sense of antisense microRNAs
5. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
6. Targeting children effective use of limited supplies of flu vaccine and could help control flu spread
7. Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds
8. Resilin springs simplify the control of crustacean limb movements
9. Study may aid efforts to prevent uncontrolled cell division in cancer
10. The challenges of avian influenza virus: Mechanism, epidemiology and control
11. Open-access membership: Reporting tool brings convenience and control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... the path of insulin action in cells in precise ... for understanding what goes wrong in diabetes. , ... David James from Sydney,s Garvan Institute of Medical Research, ... the prestigious journal Cell Metabolism . , First ... important role in the body because it helps us ...
(Date:5/20/2013)... University of Minnesota Medical School researchers from the Masonic ... University,s Brain Tumor Program, have developed a new mouse ... allow them to discover new genes and gene pathways ... published this week in the journal Nature Genetics ... in the lab of David Largaespada, Ph.D., professor in ...
(Date:5/20/2013)... URBANA - A National Science Foundation (NSF) planning grant ... Drying (CARD), a joint program of the University of ... Worcester, Mass. , "CARD will be devoted to research ... other agricultural products; forestry and paper products; chemical products; ... I professor of food science and human nutrition and ...
Breaking Biology News(10 mins):Insight into the dazzling impact of insulin in cells 2Insight into the dazzling impact of insulin in cells 3U of M researchers develop model for better testing, targeting of MPNST 2NSF approves planning grant for Center for Advanced Research in Drying 2
... WEST LAFAYETTE, Ind. - Bacteria are ... and cause disease - by manipulating a natural cellular process. , ... team that revealed how a pair of proteins from the bacteria ... protein in order to divert raw materials within the cell for ...
... Sweden, have used advanced light microscopy to show that a ... what it is mixed with. This may determine whether it ... able to identify specific cells and proteins in the skin ... understanding of the mechanisms behind contact allergy", says Carl Simonsson ...
... Scientists studying a unique collection of human skulls have ... have occurred independently through separate evolutionary events may have ... of Manchester and Barcelona examined 390 skulls from the ... human skull is highly integrated, meaning variation in one ...
Cached Biology News:Purdue scientists reveal how bacteria build homes inside healthy cells 2Purdue scientists reveal how bacteria build homes inside healthy cells 3Interactions between substances determine allergenic potential 2Human skull study causes evolutionary headache 2
(Date:5/22/2013)... and NEW ORLEANS , ... in the field of regenerative medicine, presented new data ... from Analysis Group (a leading health economics consultancy) demonstrating ... foot ulcers (DFU) and venous leg ulcers (VLU) place ... results of this research, which reveal annual costs of ...
(Date:5/22/2013)... Toronto, Ontario (PRWEB) May 22, 2013 ... of advanced sound therapy for tinnitus treatment. AudioNotch ... Destination Hearing . With clinic locations in both ... trusted provider of audiology and hearing services. AudioNotch's ... Zabell locations. , Upon entering a Destination Hearing ...
(Date:5/22/2013)... 2013 Alton Housing Authority was hit by ... said that their presence has already caused the company ... avoid such big spending, My Cleaning Products shared a way ... was said in the report that to clear the ... from that, its employees also attended a mandatory training on ...
(Date:5/22/2013)... May 22, 2013 The ability ... deciphering the information they encode. There are now ... (deep sequencing of ribosome protected fragments) that dramatically ... , Keynote speakers include Dr. Jonathan Weissman, an ... the Howard Hughes Medical Institute, who will present ...
Breaking Biology Technology:Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 2Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 3Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 4AudioNotch Tinnitus Treatment Launches Partnership With Destination Hearing 2Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2Monitoring Protein Synthesis One Codon at a Time Through Ribosome Profiling, a Webinar Hosted by Xtalks 2
... Cynvec LLC, a privately-held,biopharmaceutical company focused on developing ... the Sindbis viral vector, announced today,that it has ... effective immediately, to lead the company,s next phase ... Mr. Stonebanks will serve on Cynvec,s Board,of Directors., ...
... , - Revenues Expected to be up 26%, ... Site Limited ("The Binding Site" or the "Company"), a,privately-owned ... the year ended 30th September 2008. The full audited,results ... are expected to be GBP38.9 million, representing sales growth,of ...
... - Fourth quarter constant currency revenue growth of 12.9 ... percent, constant currency), and improving profitability reflects ... annual financial guidance for fiscal year 2009, BATESVILLE, ... ), announced unaudited financial results for its fiscal,fourth quarter ...
Cached Biology Technology:Cynvec LLC(SM) Appoints Former Johnson & Johnson Executive Frank D. Stonebanks as President and Chief Executive Officer 2Cynvec LLC(SM) Appoints Former Johnson & Johnson Executive Frank D. Stonebanks as President and Chief Executive Officer 3The Binding Site Announces Trading Update for Year Ended September 30th 2008 2The Binding Site Announces Trading Update for Year Ended September 30th 2008 3Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 2Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 3Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 4Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 5Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 6Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 7Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 8Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 9Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 10Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 11Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 12Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 13Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 14Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 15Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 16Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 17Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 18Hill-Rom Reports Fourth Quarter Revenue Growth of 14.1 Percent to $424 Million and Adjusted Earnings Per Fully Diluted Share From Continuing Operations of $0.58, an Increase of 52.6 Percent From the Prior Year 19
... An antibody made to the C-terminal VMAT2 ... kDa in postnuclear supernatants of CHO transfected ... cells (2). Some additional bands, both higher ... and remain unaffected by the inclusion of ...
... Metalloproteinase-2, Hinge Region By immunoblotting the antibody ... It reacts with free MMP-2 or MMP-2 ... buffered aqueous glycerol solution Solution in ... containing 50% glycerol and 15 mM sodium ...
Acetylcholinesterase from human and monkey....
...
Biology Products: