Navigation Links
MicroRNAs help control HIV life cycle
Date:6/25/2009

LA JOLLA, Calif., June 26, 2009 Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role in controlling the HIV life cycle. The study suggests that HIV may have co-opted this cellular defense mechanism to help the virus hide from the immune system and antiviral drugs. The research was published today in the journal Molecular Cell.

Tariq Rana, Ph.D., director of the Program for RNA Biology at Burnham, and colleagues, found that the microRNA miR29 suppresses translation of the HIV-1 genome by transporting the HIV mRNA to processing-bodies (P-bodies), where they are stored or destroyed. This results in a reduction of viral replication and infectivity. The study also showed that inhibition of miR29 enhances viral replication and infectivity. The scientists further demonstrated that strains of HIV-1 with mutations in the region of the genome that interact with miR29 are not inhibited by miR29.

"We think the virus may use this mechanism to modulate its own lifecycle, and we may be able to use this to our advantage in developing new drugs for HIV," said Dr. Rana. "Retroviral therapies greatly reduce viral load but cannot entirely eliminate it. This interaction between HIV and miR29 may contribute to that inability. Perhaps, by targeting miR29, we can force HIV into a more active state and improve our ability to eliminate it."

Rana's team looked at miR29 expression levels in infected and uninfected cells and found that miR29 expression was enhanced by HIV-1 infection. Blocking the activity of miR29 with interfering RNA resulted in increased replication and infectivity of the virus. The scientists tested the association of miR29 and HIV-1 by mutating both miR29 and its target region on the HIV virus. When either was altered, miR29s suppression
'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. MicroRNAs grease the cells circadian clockwork
2. Mass. Generals Warren Triennial Prize honors discoverers of microRNAs
3. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
4. Making sense of antisense microRNAs
5. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
6. Targeting children effective use of limited supplies of flu vaccine and could help control flu spread
7. Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds
8. Resilin springs simplify the control of crustacean limb movements
9. Study may aid efforts to prevent uncontrolled cell division in cancer
10. The challenges of avian influenza virus: Mechanism, epidemiology and control
11. Open-access membership: Reporting tool brings convenience and control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... July 31, 2014 Biometrics industry ... innovative smart technologies; companies turn towards digital currency: NXT-ID, ... ), Amazon.com Inc. (NASDAQ: AMZN ), Facebook ... GOOG ) and Microsoft Corporation (NASDAQ: MSFT) ... on the growing m-commerce market, announces a video featuring ...
(Date:7/31/2014)... While previous studies have shown that marine noise can ... scientists from the Universities of Bristol and Exeter and ... France have demonstrated that boat noise stops embryonic development ... hares, (specifically the sea slug Stylocheilus striatus ... to swim away and later feed on toxic alga ...
(Date:7/30/2014)... New York University is paving the way for ... civilians and military troops exposed to poisonous chemicalsparticularly ... An article in the current issue of the ... detoxifying organophosphates, which are compounds commonly used in ... developed by NYU School of Engineering Associate Professor ...
Breaking Biology News(10 mins):Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 3Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 4Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 6Boat noise impacts development and survival of sea hares 2Engineering a protein to prevent brain damage from toxic agents 2
... April 19, 2010 Scientists from The Scripps Research ... how certain genetic mutations lead to Type 1 diabetes. This ... 1 diabetes and other autoimmune diseases. The study was ... of Clinical Investigation on April 19, 2010, and will ...
... of the Carnegie Institution,s Department of Global Ecology, is ... sciences, the humanities and the arts, business, public affairs, ... the new class of members of the American Academy ... world,s most prestigious honorary societies, cited Field for his ...
... BUFFALO, N.Y. -- A University at Buffalo volcanologist, an expert ... how the jet stream -- the area in the atmosphere ... be the area most likely to be impacted by plumes ... Bursik, PhD, one of the foremost experts on volcanic plumes ...
Cached Biology News:Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes 2Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes 3Carnegie's Chris Field elected to American Academy of Arts & Sciences 2Volcanic ash research shows how plumes end up in the jet stream 2
(Date:7/31/2014)... 31, 2014 According to a ... for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, ... TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global ... - 2019," the global electrodes market for medical devices ... is estimated to reach a market worth USD 1,451.2 ...
(Date:7/31/2014)... Senomyx , Inc. (NASDAQ: ... taste science technologies to discover, develop, and commercialize ... ingredient supply industries, today reported financial results for ... second quarter with $33.6 million in cash and ... past quarter Senomyx achieved another important milestone with ...
(Date:7/31/2014)... San Francisco, Calif. (PRWEB) July 31, 2014 ... provides newly diagnosed patients with an overview of the ... the management of drug side effects, as well as ... , “We’re grateful to Dr. Sandy Srinivas for organizing ... 25-year survivor of kidney cancer. “Sandy and her colleagues ...
(Date:7/31/2014)... 31, 2014 Although RNA-Sequencing is ... first transcriptome-wide analyses appearing around 2008, RNA-Sequencing has ... RNA measurement. In the last several years, assays ... work with smaller input amounts, process degraded RNA, ... samples). On the bioinformatics side, there have been ...
Breaking Biology Technology:Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2
... ZyStor Therapeutics, Inc. will seek additional venture ... investigational new drug application, president and CEO Loren G. ... an informal gathering at the Innovation Monday program. He ... seek additional financing before filing the application for its ...
... solid revenue growth could not prevent Renaissance Learning, ... quarter of 2006, and as a result the company ... D. Paul said Tuesday. , ,Renaissance is a provider ... schools and districts. The company said net income, which ...
... Internet Protocol telephony gaining momentum in the private sector, ... Wisconsin product line of Norlight Telecommunications , the ... Cisco premise-based system, the Wisconsin-based voice and data provider ... vendor at a time when the telecommunications industry is ...
Cached Biology Technology:Milwaukee area biotech ZyStor seeks more funding 2Milwaukee area biotech ZyStor seeks more funding 3Renaissance earnings down 46 percent 2Norlight adds Cisco-based IP systems in Wisconsin 2
... White walled plates enhance luminescent signals ... fluorescence,• Not treated (or medium binding) ... and binds biomolecules through passive interactions,• ... of large molecules, such as antibodies, ...
...
... Columbus is a flexible, fully automated microplate strip ... to its fully automated microplate strip washing capability, ... and ease of operation. , ... include manifolds of 8, 12 or 16 channels, ...
... SBED Protein:Protein Interaction Reagent A powerful ... rapidly gained traction as an in vitro ... number of publications feature the exclusive Pierce ... study a variety of issues relating to ...
Biology Products: