Navigation Links
MicroRNAs have diagnostic and prognostic potential in urinary bladder cancer
Date:8/15/2013

did not. With one exception, no correlation was found between tumor stage and miRNA levels.

When all 15 of the selected miRNAs were considered together, they correctly classified 100% of tissues as either normal or malignant. Further analysis identified four miRNAs that led to 100% correct classification, and one miRNA (miR-130b) that by itself had an 81% accuracy rate. "These results underline the great potential of miRNAs to serve as diagnostic markers, as previously noted for other urological tumors," says lead investigator Klaus Jung, MD, the Department of Urology at the University Hospital Charit, Berlin and the Berlin Institute for Urologic Research.

The investigators found that tumor grading could not be correlated with overall survival. Yet, they were able to find two miRNAs that significantly correlated with survival: miR-141 and miR-205. miR-141 showed a trend (P=0.08) of being able to stratify patients with muscle-invasive tumors into two groups with different overall survival times. "This finding could be of clinical importance, but these results must be interpreted cautiously," says Dr. Jung. "However, previously published studies underline the possible prognostic potential of miRNAs to predict progression and disease-specific or overall survival in bladder cancer patients."

miRNAs are small non-coding RNAs that contain between 19 and 24 nucleotides. miRNAs regulate gene expression by degrading messenger RNAs or impairing their translation. In recent years there has been a growing interest in miRNAs as potential diagnostic and/or prognostic biomarkers in cancers and other diseases.


'/>"/>

Contact: Eileen Leahy
jmdmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. MicroRNAs in plants: Regulation of the regulator
2. MicroRNAs present exciting opportunities for cancer therapy and diagnosis
3. Genetic abnormality offers diagnostic hope for childrens cancer
4. 2012 Forecast for US Molecular Diagnostics Market Now Available From Global Information Inc.
5. Immunosignaturing: An accurate, affordable and stable diagnostic
6. New diagnostic tool determines aggressiveness of prostate cancer
7. Portable diagnostics designed to be shaken, not stirred
8. VolitionRX Raises Over $1 Million To Begin Clinical Trials of Blood Based Diagnostic Tests
9. Ultrasensitive biosensor promising for medical diagnostics
10. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
11. Report addresses challenges in implementing new diagnostic tests where they are needed most
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/11/2014)... , Nov. 11, 2014  Forensicon, Inc., a ... firm, is pleased to announce the promotion of ... Director of Digital Forensics. In Schiff,s new role as ... the team of digital forensics examiners and provide leadership ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
(Date:11/7/2014)... 2014 Leading Biometric companies aim to ... revolutionizing online transactions.  Companies in focus today are: NXT-ID, Inc. ... BABA ), Google Inc. (NASDAQ: GOOG ), ... EBAY ) and MasterCard Inc. (NYSE: MA) ... a biometric authentication company focused on the growing mobile commerce ...
(Date:11/6/2014)... November 6, 2014 - Insilico Medicine, Inc, a ... and age related diseases announced a research collaboration ... cancer, Champions Oncology, Inc (OTC: CSBR). , "There ... personalized medicine, but Champions Oncology,s TumorGraft technology is ... the chemotherapy regimen experimentally generating vast amounts of ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... of an animal cell is like a small city, ... and other life functions. A network of intercellular "highways," ... to move speedily about the cell to keep this ... the journal Proceedings of the National Academy of ...
... Calif. December 13, 2012 -- 23andMe, ... of Ancestry Composition, a new feature that provides state-of-the-art ... reference populations, the feature indicates what percent of a ... The analysis includes DNA inherited from all ancestors on ...
... developed a new method for studying parasite numbers in the ... the recording of video footage of worms inside seabird stomachs ... of parasites on seabird populations. The research is published today ... Ecology and Evolution . The research team trialled the ...
Cached Biology News:Study sheds light on how cells transport materials along crowded intercellular 'highways' 2Study sheds light on how cells transport materials along crowded intercellular 'highways' 323andMe's Ancestry Composition reveals people's ancestral origins going back 500+ years 2Scientists develop novel method to study parasite numbers in wild seabirds 2Scientists develop novel method to study parasite numbers in wild seabirds 3
(Date:11/21/2014)... England , Nov. 21, 2014   TRU-D SmartUVC ... will feature their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, ... this week from Nov. 23 to 26 at Stand 23. ... is the United Kingdom,s largest infection-related ... infection prevention societies to one of the leading events of ...
(Date:11/21/2014)... Angeles, CA (PRWEB) November 20, 2014 ... “A Short Walk to the Other Side” published ... an “Award-Winning Finalist in the “Fiction: Short Story” category ... , Jeffrey Keen, President and CEO of USA Book ... from mainstream and independent publishers, including Simon & Schuster, ...
(Date:11/21/2014)... The November 2014 issue of BioTechniques ( ... journal featuring the following articles:, , ... in the retina , DNA from fingermarks ... chromogenic substrates in zebrafish , Re-use of ... , Nuclear LC3-positive puncta in stressed cells ...
(Date:11/21/2014)... Dallas, Texas (PRWEB) November 21, 2014 ... China Sodium Ferrocyanide Industry” is a professional and ... it provides Sodium ferrocyanide information, like its ... well as industry overview. This report covers the ... well as global (such as the US, Europe, ...
Breaking Biology Technology:TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3
... Sept. 30, 2011 Life Technologies Corporation ... to protocols detailing key steps of the Ion PGM™ ... that are at the core of Ion semiconductor sequencing are ... PGM users, as well as scientists that are closely watching ...
... and VU University Amsterdam in the Netherlands have demonstrated that ... with which hydrogen gas is released when stored in a ... greater the speed at which the hydrogen gas makes its ... in the October issue of the scientific journal Advanced Energy ...
... 2011 Today BioSpace , the leading life ... Beach™ Hotbed Campaign, marking the 14th edition. ... across Southern California. Each company,s brand is added to ... is promoted online as well as at industry events ...
Cached Biology Technology:Open Ion Community Fuels Race to Win Three $1M Prizes 2Open Ion Community Fuels Race to Win Three $1M Prizes 3Open Ion Community Fuels Race to Win Three $1M Prizes 4Open Ion Community Fuels Race to Win Three $1M Prizes 5Hydrogen released to fuel cell more quickly when stored in metal nanoparticles 2BioSpace Spotlights Southern California's Life Science Community 2
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
Applications: Immunohistochemistry, ISH, FISH, CISH....
Immunogen: Synthetic peptide (KLH conjugated): L(506) S K S S S Q I R M S G L P A D N L A T(525) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Attachments: Clip bar for tubes 10 to 19 mm in diameter Overall Dimension Height IC: 6 (15.2) Overall Dimension Length IC: 18.5 (46.9) Overall Dimension Width IC: 4 (10.2)...
Biology Products: