Navigation Links
MicroRNAs grease the cell's circadian clockwork
Date:5/31/2009

wing cells to reduce the activity of certain genes at a given time.

"We have studied the role of a microRNA called miR-122, which is highly abundant in liver. It has caught considerable attention for its role in regulating cholesterol and lipid metabolism and in aiding the replication of hepatitis C virus" explains David Gatfield, one of Professor Schibler's collaborators.

Performance of the molecular oscillator

The researchers' team has discovered that miR-122 is tightly embedded in the output system of the circadian clock in hepatocytes. This microRNA regulates numerous circadian genes, impinging on the amplitude and duration of their expression. Conversely, the synthesis of miR-122 involves a transcription factor that is otherwise known for its function in the circadian clock.

and viral replication

"It will be exciting to investigate whether the connection between circadian rhythms and miR-122 also extends to this microRNA's role in hepatitis C virus replication", points out David Gatfield. Knowing whether viral multiplication is gated to specific times of the day would contribute significantly to our understanding of the life cycle of this formidable pathogen.

Scientists have uncovered over the past years the role of microRNAs in crucial physiological functions such as growth and programmed cell death, as well as carcinogenesis. Ueli Schibler's team adds a stone to this edifice by placing miR-122 within the clock gene machinery.


'/>"/>

Contact: Heather Cosel-Pieper
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Making sense of antisense microRNAs
2. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
3. Mass. Generals Warren Triennial Prize honors discoverers of microRNAs
4. ESF EURYI award winner aims to stop cancer cells reading their own DNA
5. Newly created cancer stem cells could aid breast cancer research
6. AIDS interferes with stem cells in the brain
7. Clemson scientists shed light on molecules in living cells
8. Social habits of cells may hold key to fighting diseases
9. UF scientists reveal how dietary restriction cleans cells
10. Human derived stem cells can repair rat hearts damaged by heart attack
11. Scientists identify embryonic stem cells by appearance alone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... fold them: modern materials that are light, flexible and ... skin or electronic paper. , Making such concepts affordable ... new way of working with copper nanowires and a ... Previous success in the field of ultra-lightweight "aerogel monoliths" ... and silver nanowires. , By turning instead to ...
(Date:8/28/2014)... study reports that an expansion of marine protected areas ... ecological functions. According to investigators from the Wildlife ... fish have focused on saving the largest numbers of ... provide key and difficult-to-replace ecological functions. , ... by fish species that also are food for millions ...
(Date:8/28/2014)... the University of Minnesota have developed an animal research ... for muscle regeneration research as well as studies of ... research is published in the current edition of the ... treatment for FSHD, which is thought by many to ... is an unusual genetic disorder because, unlike most genetic ...
Breaking Biology News(10 mins):Copper shines as flexible conductor 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2UMN researchers find animal model for understudied type of muscular dystrophy 2
... 18 announcement that only 25 to 34 of the Amur ... wild, World Wildlife Fund says the number must now be ... Anonymous tips led officers of two leopard anti-poaching squads to ... miles from Bamburovo village within the watershed of Alimovka River ...
... and the bees. But apparently when it comes to birds, ... the difference is genetic. Species with differentiated sex chromosomes (X ... that males and females get different-sized portions of sex chromosome ... But research published today in the Journal of Biology shows ...
... that low birthweight babies born with low sodium (salt) in ... sodium later in life. In the study, researchers also ... sodium blood serum consumed ~1700 mg more sodium per day ... These data, taken together with other recent findings, make it ...
Cached Biology News:Bird sex is something else 2Like salty food? Chances are you had low blood sodium when you were born 2Like salty food? Chances are you had low blood sodium when you were born 3
(Date:8/29/2014)... New York (PRWEB) August 29, 2014 ... valued at $5.6 billion in 2019. It is ... from 2013 to 2019, and was valued at ... report published by Transparency Market Research. , For ... visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, ...
(Date:8/29/2014)... August 29, 2014 Pittcon is pleased ... and colleague Koichiro Matsuda, Horiba Scientific, have organized a ... 5, 2014. JASIS , Asia’s largest analytical and ... in Makuhari Messe, Japan. , The four speakers ... Bioanalysis from Single Molecules to Single Cells” will present ...
(Date:8/29/2014)... Hills, NY (PRWEB) August 29, 2014 ... Burnt Hills Veterinary Hospital are seeking candidates to participate ... dogs with osteoarthritis. The ultimate goal of this ... donor stem cells into one or two arthritically affected ... treated joints. , Candidates for the current investigational ...
(Date:8/29/2014)... 29, 2014 Due to a misstatement posted ... the Adult Stem Cell Technology Center, LLC ( ASCTC ) ... cell therapy research that might benefit ALS patients. Because ... new stem cell technologies and therapeutic applications, FRC listed ASCTC ... Challenge donors who wish not to support research that ...
Breaking Biology Technology:Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3
... Bioscience Authority has taken bold action to significantly increase ... bioscience businesses -- and to lead the state,s economic ... in eight private venture capital funds. The KBA investments ... from around the country in Kansas bioscience companies. , ...
... Soligenix, Inc. (Soligenix or the Company), (OTC Bulletin Board: ... J. Rubin, MD, has been appointed to its Board ... career in the healthcare industry and government. Among his ... national health policy and management consulting firm The Lewin ...
... ... Scientific Advisory Board , ... Village, Calif. (PRWEB) October 9, 2009 -- Nanogea, a nano-biotech company focused on commercializing the ... Thomas Caskey and Dr. Saul Tendler have joined its scientific advisory board. , , ...
Cached Biology Technology:Kansas Bioscience Authority Commits $50 Million to Increase Venture Capital, Accelerate Bioscience Business Growth 2Kansas Bioscience Authority Commits $50 Million to Increase Venture Capital, Accelerate Bioscience Business Growth 3Soligenix Appoints Robert J. Rubin, MD, to its Board of Directors 2Soligenix Appoints Robert J. Rubin, MD, to its Board of Directors 3Soligenix Appoints Robert J. Rubin, MD, to its Board of Directors 4Nanogea Announces New Scientific Advisory Board Members 2Nanogea Announces New Scientific Advisory Board Members 3
... Special optically clear polystyrene formulation , High ... applications , Plates are certified for ... variation , Eight-well strips fit snugly ... while in use even if turned upside ...
12 breakable polypropylene strips of 8 wells each held in a rigid frame. Ideal for antibody assays....
...
... Human IgM Assay Kit to address the ... assay for Human IgM that eliminates the ... a simple mix-and-read assay that allows the ... ng/ml in approximately 30 minutes. The Pierce ...
Biology Products: