Navigation Links
MicroRNA suppresses prostate cancer stem cells and metastasis
Date:1/16/2011

HOUSTON A small slice of RNA inhibits prostate cancer metastasis by suppressing a surface protein commonly found on prostate cancer stem cells. A research team led by scientists at The University of Texas MD Anderson Cancer Center reported today in an advance online publication at Nature Medicine.

"Our findings are the first to profile a microRNA expression pattern in prostate cancer stem cells and also establish a strong rationale for developing the microRNA miR-34a as a new treatment option for prostate cancer," said senior author Dean Tang, Ph.D., professor in MD Anderson's Department of Molecular Carcinogenesis.

MicroRNAs, or miRNAs, are short, single-stranded bits of RNA that regulate the messenger RNA expressed by genes to create a protein.

Cancer stem cells are capable of self-renewal, have enhanced tumor-initiating ability and are generally more resistant to treatment than other cancer cells. They are associated with tumor recurrence and metastasis, the lethal spreading of cancer to other organs. These capacities are more prevalent in cancer cells that feature a specific cell surface protein called CD44, Tang said.

"CD44 has long been linked to promotion of tumor development and, especially, to cancer metastasis," Tang said. "Many cancer stem cells overexpress this surface adhesion molecule. Another significant finding from our study is identifying CD44 itself as a direct and functional target of miR-34a."

MicroRNA goes up, CD44 and cancer stem cells fall

In a series of lab experiments with cell lines, human xenograft tumors in mice and primary human prostate cancer samples, the researchers demonstrated that miR-34a inhibits prostate cancer stem cells by suppressing CD44.

  • miR-34a is greatly reduced in prostate cancer cells that express high levels of CD44 on the cell surface. In 18 human prostate tumors, the microRNA was expressed at 25 to 70 percent of the levels found i
    '/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists identify novel inhibitor of human microRNA
2. MicroRNAs grease the cells circadian clockwork
3. MicroRNAs help control HIV life cycle
4. MicroRNA in human saliva may help diagnose oral cancer
5. Scientists use microRNAs to track evolutionary history for first time
6. Penn biologists determine microRNA activity is suppressed in mouse ovum
7. Pitt researchers discover big role for microRNA in lethal lung fibrosis
8. MicroRNA network study implicates rewired interactions in cancer
9. Study of microRNA helps NIH scientists unlock secrets of immune cells
10. Red blood cells have a tiny but effective protector -- microRNA
11. Newly identified RNA sequence is key in microRNA processing
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MicroRNA suppresses prostate cancer stem cells and metastasis
(Date:12/10/2014)... NEW YORK , Dec. 8, 2014 You,ve ... online banking account but can,t remember your password, site key ... birthday? Who was your first grade teacher? ... launches the app that will finally put an ... PINs – 1U TM . 1U leverages a ...
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... the University of Leeds, has found that a common ... monoxide poisoning. Animal studies have shown that the ... deaths from arrhythmias irregular or abnormally paced heartbeats ... The findings could have important implications for the development ...
... August 6, 2012 Individuals with mutations in BRCA1 and ... and ovarian cancers. Families at risk have been seeking ... but the standard method of direct sequencing is labor-intensive, costly, ... BRCA2 genes. A group of Canadian scientists has developed ...
... is able to source food from the land as well as ... University of London has found. Scientists analysed the behaviour of ... the water level of the lake was low, the crayfish found ... journal PLoS ONE today (3 August 2012). Lead ...
Cached Biology News:Anti-angina drug shows protective effects from carbon monoxide 2Anti-angina drug shows protective effects from carbon monoxide 3New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer 2Crayfish species proves to be the ultimate survivor 2
(Date:12/24/2014)... On Friday, December 19, 2014, President ... and Continuing Resolution Appropriations Act of 2015, which ... eligible to receive funding through the Congressionally Directed ... of Defense (DoD). The Hydrocephalus Association (HA), working ... is celebrating this victory for the over 1 ...
(Date:12/24/2014)... CA (PRWEB) December 23, 2014 Pipette.com ... where their Twitter followers can submit their #HolidayInTheLab pictures ... and their lab mates. , For those struggling to ... mates, the Pipette.com Holiday in the Lab Contest provides ... Pipette.com Twitter followers to send pictures of their ...
(Date:12/24/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ) ... Application (CTA) with the United Kingdom,s ... approval to initiate clinical trials for the continued development ... on the Company receiving CTA regulatory approval, the Company ... the safety, tolerability and dose escalation of Anatabine Citrate ...
(Date:12/22/2014)... HILL, N.C. , Dec. 22, 2014 /PRNewswire/ ... today announced that it has signed a letter ... company that has developed and patented a nanotechnology-based ... medical diagnostics products that enable rapid on-site collection ... alcohol use/abuse and health issues in an immediate, ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2
... ... has linked a developmental checkpoint in the differentiation of hematopoietic progenitors into specific T cell ... this week, the discovery lends support to a new model for the development of blood ... (PRWeb UK) ...
... Mass. , July 1 X-Chem, Inc. ... with Roche to apply X-Chem,s proprietary platform to the ... high-value therapeutic targets. As part of the agreement, Roche ... discovery milestones, and technology access fees. Roche will have ...
... June 30 RSB Spine, LLC, a medical device company ... disc disease, today announced a 50% sales increase for the second quarter ... the company reported record sales for the month of June. , ... RSB Spine Chief Executive Officer ...
Cached Biology Technology:The Last Checkpoint to T Cell Fate 2X-Chem and Roche Enter Into Drug Discovery Collaboration and License Agreement 2
... DNA Engine Opticon 2 real-time PCR detection ... for fluorescence excitation (470-505 nm) and two ... 540-700 nm). The Opticon 2 system is ... which includes a thermal gradient feature. This ...
Fingerprinting II Basic software is used for analyzing fingerprint sample types (electrophoretic gels, HPLC and other chromatographic patterns, spectrophotometric and densitometric curves)....
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
... identification and library manager ... that adds capabilities for ... identification of unknowns against ... of the same taxon ...
Biology Products: