Navigation Links
MicroRNA network study implicates rewired interactions in cancer
Date:5/2/2010

g groups of miRNAs exhibiting highly related patterns of expression. Once relationships were recognized, they could then build a genetic network revealing the most highly connected miRNAs, called "hubs."

When comparing the miRNA networks built from normal tissues to the networks built from tumor samples, Croce's team found cases where the miRNA networks have been reprogrammed in cancer. In some cases, they found that the highly connected miRNA hubs changed between cancer and normal tissues.

They also identified even more extreme cases of tumor network changes. "Groups of miRNAs go awry and exit from the 'social network' altogether," Croce said. "In solid cancers there can be a few, or more, groups of such misbehaved miRNAs, while in leukemias we found only one or two." Some of these "unsocial" miRNAs have well-known roles in cancer, but others had not been implicated until now.

This work is particularly significant in that novel cancer genes have been discovered utilizing a strategy based on relationships, rather than up or down regulation of expression. "The miRNAs we discovered can now be used as targets for drug development," Croce added, "or to pinpoint candidate proteins, which, in turn, they regulate."


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Pitt researchers discover big role for microRNA in lethal lung fibrosis
2. Penn biologists determine microRNA activity is suppressed in mouse ovum
3. Scientists use microRNAs to track evolutionary history for first time
4. MicroRNA in human saliva may help diagnose oral cancer
5. MicroRNAs help control HIV life cycle
6. MicroRNAs grease the cells circadian clockwork
7. Scientists identify novel inhibitor of human microRNA
8. Mass. Generals Warren Triennial Prize honors discoverers of microRNAs
9. MicroRNA implicated as molecular factor in alcohol tolerance
10. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
11. Yale scientists show that a microRNA can reduce lung cancer growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2015)... 2015 The consulting company Frost & ... manufacturer DERMALOG and its customized solutions and products for ... of the Year Award". DERMALOG is particularly successful with a ... -Cross reference: Picture is available at AP Images ... On Thursday evening, in South Africa,s ...
(Date:8/19/2015)... 2015  VOXX International Corporation (Nasdaq: VOXX ... a Definitive Agreement to purchase the assets, inclusive ... leader EyeLock through an acquiring entity.  Upon consummation ... interest in the acquiring entity. The closing of ... diligence.  Expanding on its existing supply chain and ...
(Date:8/12/2015)... Florida , August 12, 2015 ... pace of mobile payment innovation and advanced biometrics technology ... replace the way consumers rely on using their credit ... with reinventing the future for payment services led by ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... worst enemy , Unlocking ancient rice secrets to overcome ... Reducing crop losses with cereals that respond to pest ... , Over 40 international research organisations are joining forces ... to improve food security in developing countries., Funding has ...
... culturally, and economically important plant in the Western United ... harvesters now have a comprehensive report about the species. ... Beargrass ( Xerophyllum tenax ), published by the U.S. ... gaps and areas for future research. It also documents ...
... with multiple sclerosis at the University of California, San Francisco ... exchange" that allows the disease-causing cells to move in and ... from spinal fluid and blood samples, are called B cells, ... but sometimes react strongly with the body itself. One of ...
Cached Biology News:Major international push to maximize bioscience research to help world's poorest farmers 2Major international push to maximize bioscience research to help world's poorest farmers 3Major international push to maximize bioscience research to help world's poorest farmers 4Beargrass, a plant of many roles, is focus of new report 2Multiple sclerosis 'immune exchange' between brain and blood is uncovered 2
(Date:8/28/2015)... ... August 28, 2015 , ... Pittcon is pleased to ... a session on chemical spectroscopic imaging at JASIS 2015 (Japan Analytical & Scientific ... analytical and scientific instruments show which will be held at International Conference Hall ...
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... Capital ... solve complex business problems, is pleased to announce their ranking as one of the ... ranking of the fastest-growing private companies across the nation. , “It is truly an ...
(Date:8/27/2015)... GUELPH, ON , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. ... the three and six-month periods ended June 30, 2015. Biorem,s complete ... ( www.sedar.com ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per ... , 2014 , 2015 , ... 9,398 , 4,433 Gross profit , 1,656 ...
(Date:8/27/2015)... 27, 2015 In response to recent ... and The US Postal Service to no longer ... ,select agents, by the CDC, Marken reaffirmed today ... sensitive shipments. Marken uses its flexible ... and certified personnel to ensure the safe and ...
Breaking Biology Technology:U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... this series on e-discovery, we discussed the amendments to ... to address and resolve issues regarding the discovery of ... or a system of satisfying your obligation to preserve ... at risk. This article discusses how to minimize ...
... Madison, Wis. - NimbleGen Systems , a manufacturer ... toward an initial public offering of stock following its acquisition ... , ,NimbleGen had sought to raise $75 million in the ... by the two companies, Roche will acquire 100 percent of ...
... - In an effort to revive Legislative support for ... at Republican skeptics, suggesting that GOP lawmakers are paying lip ... farmers, manufacturers, and entrepreneurs. , ,Doyle, in his most pointed ... more than 100,000 tons of biomass resources and would benefit ...
Cached Biology Technology:Finding Safe Harbor in a sea of electronic discovery 2Finding Safe Harbor in a sea of electronic discovery 3NimbleGen to discontinue IPO after Roche's $272.5 million acquisition 2NimbleGen to discontinue IPO after Roche's $272.5 million acquisition 3NimbleGen to discontinue IPO after Roche's $272.5 million acquisition 4
Template and primers for preparation of internal control spots...
Cross reactivity to St. Louis encephalitis (MSI-7) is determined by ELISA....
...
UV LAMP 254 NM 8 WATT, 1 EA. Category: Nucleid Acid Detection Systems....
Biology Products: