Navigation Links
MicroRNA network study implicates rewired interactions in cancer
Date:5/2/2010

May 3, 2010 Genes interact in complex networks that govern cellular processes, much like people connect a social network through relationships. Researchers are now discovering how biological networks change and are rewired in cancer. In a study published today in Genome Research (www.genome.org), scientists have analyzed the genetic networks of microRNAs in tumors, shedding light on how interactions go awry in disease.

MicroRNAs (miRNAs) are short RNA molecules encoded by plant, animal, and viral genomes that have garnered significant interest for their ability to regulate gene expression. Many critical biological processes are regulated by miRNAs, and recent evidence has shown that alterations in miRNA expression is involved in human tumor development and metastasis.

Investigations into the role of miRNAs in cancer up until now have largely focused on the function and expression of individual miRNAs, but miRNA function is more complex and interwoven. "MicroRNAs were always considered as singles, generally unrelated to each other in the miRNA world," said Ohio State University researcher Carlo Croce. "We did not know much about how miRNAs cooperate."

Because a single miRNA is likely to regulate many genes, and each target gene may be regulated by more than one miRNA, Croce and an international team of colleagues suggested that in order to capture the complex patterns of miRNA expression in cancer, the system must be thought of as a "social network" that coordinates the delicate balance of gene regulation.

Croce explained that in healthy tissues, miRNAs are connected in networks and different cell types have different network connections. In cancer, it is likely that normal network interactions have become disrupted or rewired, contributing to disease.

The group analyzed patterns of miRNA expression levels in a large set of normal and cancerous tissue samples, mapping groups of miRNAs exhibiting highly related patterns of expression. Once relationships were recognized, they could then build a genetic network revealing the most highly connected miRNAs, called "hubs."

When comparing the miRNA networks built from normal tissues to the networks built from tumor samples, Croce's team found cases where the miRNA networks have been reprogrammed in cancer. In some cases, they found that the highly connected miRNA hubs changed between cancer and normal tissues.

They also identified even more extreme cases of tumor network changes. "Groups of miRNAs go awry and exit from the 'social network' altogether," Croce said. "In solid cancers there can be a few, or more, groups of such misbehaved miRNAs, while in leukemias we found only one or two." Some of these "unsocial" miRNAs have well-known roles in cancer, but others had not been implicated until now.

This work is particularly significant in that novel cancer genes have been discovered utilizing a strategy based on relationships, rather than up or down regulation of expression. "The miRNAs we discovered can now be used as targets for drug development," Croce added, "or to pinpoint candidate proteins, which, in turn, they regulate."


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Related biology news :

1. Pitt researchers discover big role for microRNA in lethal lung fibrosis
2. Penn biologists determine microRNA activity is suppressed in mouse ovum
3. Scientists use microRNAs to track evolutionary history for first time
4. MicroRNA in human saliva may help diagnose oral cancer
5. MicroRNAs help control HIV life cycle
6. MicroRNAs grease the cells circadian clockwork
7. Scientists identify novel inhibitor of human microRNA
8. Mass. Generals Warren Triennial Prize honors discoverers of microRNAs
9. MicroRNA implicated as molecular factor in alcohol tolerance
10. Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
11. Yale scientists show that a microRNA can reduce lung cancer growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... , February 8, 2016 ... platform which presents innovation for clients, comfort and ... called VoiceKey. --> Worldcore is ... innovation for clients, comfort and unbeatable security, with ... --> Worldcore is the first ...
(Date:2/3/2016)... , February 3, 2016 ... new market research report "Automated Fingerprint Identification System Market ... Latent Search), Application (Banking & Finance, Government, Healthcare, and ... by MarketsandMarkets, the market is expected to be worth ... of 21.0% between 2015 and 2020. The transformation and ...
(Date:2/2/2016)... This BCC Research report provides a ... the recent advances in high throughput ‘omic platforms ... forward. Includes forecast through 2019. Use ... opportunities that exist in the bioinformatic market. Analyze ... well as IT and bioinformatics service providers. Analyze ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... -- Spectra BioPharma Selling Solutions (Spectra) is a new ... the experience, expertise, operational delivery and customer focus ... Created in concert with industry leading commercial experts, ... tactical needs of its clients by providing value-based ... and non-personal promotion. --> ...
(Date:2/11/2016)... Feb. 11, 2016   BioInformant announces the ... Cell Research Products, Opportunities, Tools, and Technologies – Market ... The first ... stem cell industry, BioInformant has more than a decade ... cell market, by stem cell type. This powerful 175 ...
(Date:2/10/2016)... 2016 Early-career researchers from ... , Uganda and Yemen ... and nutrition   Indonesia , Nepal ... and Yemen are being honored for their accomplishments ... also celebrated for mentoring young women scientists who are pursuing careers in ...
(Date:2/10/2016)... -- IsoRay, Inc. (NYSE MKT: ISR), a medical technology company ... for the treatment of prostate, brain, lung, head and ... for the second quarter and six months of fiscal ... --> --> Revenue was $1.19 ... ended December 31, 2015, a 12% increase compared to ...
Breaking Biology Technology: