Navigation Links
MicroRNA molecule found to be a potent tumor-suppressor in lung cancer
Date:9/16/2013

COLUMBUS, Ohio New research shows that microRNA-486 is a potent tumor-suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung-cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

The preclinical study was led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James). It found that microRNA-486 (miR-486) directly targets the insulin growth-factor pathway, which is important for cell survival and proliferation. Alternations in the pathway are believed to play an early role in tumor initiation and progression.

The researchers further found that miR-486 is itself regulated by the tumor-suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR-486 is partially dependent upon functional p53.

Published in the Proceedings of the National Academy of Sciences, the study suggests that miR-486 might serve as a biomarker for lung-cancer patients who might respond to treatment with insulin-growth-factor inhibitors.

"It wasn't known whether miR-486 functioned as an oncogene or a tumor-suppressor gene in lung cancer," says co-corresponding author Patrick Nana-Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC James Molecular Biology and Cancer Genetics Program.

"miR-486 appears to be a biomarker for lung cancer, but its mechanisms of action remain unclear," he says. "These findings show that miR-486 serves a tumor-suppressor function in lung cancer, and that miR-486 action is partially dependent on p53."

"This partial reliance of one tumor-suppressor on another was a surprise," says principal investigator and co-corresponding author Carlo M. Croce, MD, director of Ohio State's Human Cancer Genetics program and the John W. Wolfe Chair in Human Cancer Genetics at the OSUCCC James. "We don't know yet what implications, if any, this might have for the development of targeted therapies."

MicroRNAs are a class of short, non-coding RNAs that regulate the translation or degradation of messenger RNA and therefore the proteins that cells make. Research is showing that certain microRNAs are frequently dysregulated in cancer.

Nana-Sinkam and his colleagues examined lung-tumor samples from 81 patients with stage-1 nonsmall-cell lung cancer and tumor-cell lines. Analyses identified miR-486 as the most decreased of microRNAs in the cells, so the researchers chose it for further investigation.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center
Source:Eurekalert

Related biology news :

1. MicroRNA controls malignancy and resistance of breast cancer cells
2. Its a trap! New laboratory technique captures microRNA targets
3. MicroRNAs in plants: Regulation of the regulator
4. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
5. MicroRNAs present exciting opportunities for cancer therapy and diagnosis
6. Triple-negative breast cancer subtypes identified using microRNA
7. Study: MicroRNA cooperation mutes breast cancer oncogenes
8. MicroRNAs have diagnostic and prognostic potential in urinary bladder cancer
9. Biomarkers Market: Epigenetic & MicroRNA Biomarkers Report
10. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
11. Droplet Digital PCR enables reproducible quantification of microRNA biomarkers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... Who risk to be deprived of its imprint in ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT EACH ... using capacitive technology represent a fast growing market, especially ... increase of 360% of the number of fingerprint sensor ... market between 2014 and 2017 (source : N+1 Singer, ...
(Date:3/1/2017)... March 1, 2017  Aware, Inc. (NASDAQ: AWRE), a ... Richard P. Moberg has resigned, effective March ... Chief Financial Officer and Treasurer of Aware citing a ... as a member of the Board of Directors of ... co-Chief Executive Officer and co-President, General Counsel has been ...
(Date:2/28/2017)... -- News solutions for biometrics, bag drop and New ... At ... 16 March, Materna will present its complete end-to-end passenger journey, ... a real benefit for passengers. To accelerate the whole passenger ... point solutions to take passengers through the complete integrated process ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... March 28, 2017 , ... T3D Therapeutics, ... new orally administered treatment for Alzheimer’s disease (AD), today announced that Dr. Kathleen ... we seek to uniquely treat the metabolic dysfunctions inherent in Alzheimer’s disease and ...
(Date:3/27/2017)... ... March 27, 2017 , ... IsoPlexis Corporation (IsoPlexis), a venture ... and more through a single-cell precision engineering platform, today announced it has received ... in the laboratory of Dr. James Heath at the California Institute of Technology, ...
(Date:3/27/2017)... , March 27, 2017 Infectex Ltd., a Russian portfolio ... 2b-3 clinical study of SQ109 added to the standard drug therapy regimen in patients ... scientists at Sequella, Inc. ( USA ) and the US National Institutes ... ... Maxwell Biotech Venture Fund Logo ...
(Date:3/27/2017)... 27, 2017 The new research portal ... library of reports on Valero Energy , offering extensive ... petrochemical industries. ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO) The latest ... go green. Ethanol today, even though touted as a green ...
Breaking Biology Technology: