Navigation Links
MicroRNA molecule found to be a potent tumor-suppressor in lung cancer
Date:9/16/2013

COLUMBUS, Ohio New research shows that microRNA-486 is a potent tumor-suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung-cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

The preclinical study was led by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James). It found that microRNA-486 (miR-486) directly targets the insulin growth-factor pathway, which is important for cell survival and proliferation. Alternations in the pathway are believed to play an early role in tumor initiation and progression.

The researchers further found that miR-486 is itself regulated by the tumor-suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR-486 is partially dependent upon functional p53.

Published in the Proceedings of the National Academy of Sciences, the study suggests that miR-486 might serve as a biomarker for lung-cancer patients who might respond to treatment with insulin-growth-factor inhibitors.

"It wasn't known whether miR-486 functioned as an oncogene or a tumor-suppressor gene in lung cancer," says co-corresponding author Patrick Nana-Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC James Molecular Biology and Cancer Genetics Program.

"miR-486 appears to be a biomarker for lung cancer, but its mechanisms of action remain unclear," he says. "These findings show that miR-486 serves a tumor-suppressor function in lung cancer, and that miR-486 action is partially dependent on p53."

"This partial reliance of one tumor-suppressor on another was a surprise," says principal investigator and co-corresponding author Carlo M. Croce, MD, director of Ohio State's Human Cancer Genetics program and the John W. Wolfe Chair in Human Cancer Genetics at the OS
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. MicroRNA controls malignancy and resistance of breast cancer cells
2. Its a trap! New laboratory technique captures microRNA targets
3. MicroRNAs in plants: Regulation of the regulator
4. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
5. MicroRNAs present exciting opportunities for cancer therapy and diagnosis
6. Triple-negative breast cancer subtypes identified using microRNA
7. Study: MicroRNA cooperation mutes breast cancer oncogenes
8. MicroRNAs have diagnostic and prognostic potential in urinary bladder cancer
9. Biomarkers Market: Epigenetic & MicroRNA Biomarkers Report
10. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
11. Droplet Digital PCR enables reproducible quantification of microRNA biomarkers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... creating a new professorship in tissue engineering to ... Molecular Engineering and the Marine Biological Laboratory, supported ... and Eugene Bell Foundation., The Eugene Bell Professorship ... for Molecular Engineering. That endowed chair holder also ... Eugene Bell Center for Regenerative Biology and Tissue ...
(Date:7/11/2014)... researchers at the National Institute of Standards and ... their work more effectively, they often prove that ... was the case recently for M. Lorna De ... the growing specialization of glycomics. Glycomics is the ... glycans that are attached to proteins and lipids ...
(Date:7/11/2014)... animals often develop relationships with other group members to ... wild chacma baboons the strategy for grooming activities shows ... just published in the scientific journal Biology Letters ... baboons is not practiced without ulterior motives. To be ... the individual, while grooming another individual can provide access ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2Baboons groom early in the day to get benefits later 2
... cancer researchers have discovered a process that may explain ... one day lead to new therapies that prevent defective ... reported June 8 in the advance online issue of ... Biology Organization (EMBO). , Tumor cells that grow aggressively ...
... that genes control traits such as eye and hair color. ... found that the genes of one organism not only control ... of thousands of other organisms in a community. , ... an entire ecosystem. , "We're pushing a whole new field ...
... are leading a nationwide clinical trial to determine whether ... treatment for early-stage breast cancer. , "By using ... tumor will respond to chemotherapy, we're hoping to more ... hormonal therapy alone and which patients will truly benefit ...
Cached Biology News:MIT sheds light on how tumor cells form 2It's all in the genes 2It's all in the genes 3New genetic test for breast cancer 2
(Date:7/10/2014)... Burkina Faso (PRWEB) July 10, 2014 ... Faso, today have access to an additional family ... increase access to contraception at all levels of ... a lower-dose formulation of a widely used contraceptive—Pfizer’s ... system. , Burkina Faso is the first of ...
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, and ... purchased a DNA test to unravel the ... a lifetime of memories, sharing, and closeness. In fact, ... genuinely brought the family closer together. , Recently, ... history and prior to taking the genetic ancestry ...
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
(Date:7/10/2014)... Calif., July 10, 2014   Ceres, Inc . ... seed company, announced today financial results for the three ... on its business. Ceres reported that the ... product performance this growing season in Brazil, which concluded ... the company,s sorghum evaluation areas for part of the ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... 32% Over Second Quarter 2007, - EPS of $0.63 per Basic Share, ... Charges of $1.36 per Basic Share, Increase of ... 56% Over Second Quarter 2007, SILVER ... announced its results of,operations for the quarter ended June 30, 2008., ...
... Granted in ... 2007, Expanding Commercial Protection, LONDON, July 31 ... biotechnology company, today announced that,the United States Patent and ... The Patent Office issued a ,Notice of,Allowance, for patent ...
... known that yeast, the humble ingredient that goes into our ... others. Glucose, their favorite food, provides more energy than any ... to ensure that they consume as much glucose as possible ... identified a previously unknown mechanism that allows yeast to shut ...
Cached Biology Technology:United Therapeutics Reports Second Quarter 2008 Financial Results 2United Therapeutics Reports Second Quarter 2008 Financial Results 3United Therapeutics Reports Second Quarter 2008 Financial Results 4United Therapeutics Reports Second Quarter 2008 Financial Results 5United Therapeutics Reports Second Quarter 2008 Financial Results 6Silence Therapeutics Receives Allowance from United States Patent and Trademark Office for its Core RNAi Patent 2Silence Therapeutics Receives Allowance from United States Patent and Trademark Office for its Core RNAi Patent 3Silence Therapeutics Receives Allowance from United States Patent and Trademark Office for its Core RNAi Patent 4New yeast trick for eating favorite food: Details in Nature paper 2New yeast trick for eating favorite food: Details in Nature paper 3
... Thermo Savant SpeedVac Concentrators set the standard ... SC110A SpeedVac uses a combination of centrifugal force, ... a single run., SC110A comes equipped with:, , ... chemical compatibility , ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
...
... series of vacuum concentrators/centrifugal evaporators offers a ... to rapid and safe concentration of heat-labile ... with oil-free or high vacuum pumps, a ... selection of rotors (eliminating sample loss by ...
Biology Products: