Navigation Links
MicroRNA controls malignancy and resistance of breast cancer cells
Date:5/4/2012

Many breast cancer patients are treated with a drug called tamoxifen. The substance blocks the effect of estrogen and thus suppresses the growth signals of this hormone in cancer cells. When resistance to the drug develops, tumor cells change their growth program: They change their behavior and shape, become more mobile and also adopt the ability to invade surrounding tissue. Scientists working with PD (Associate Professor) Dr. Stefan Wiemann of the German Cancer Research Center (DKFZ) have now also observed these changes in tamoxifen resistant breast cancer cells.

"Resistances to drugs are the main reason why therapies fail and disease progresses in many cancers," Wiemann explains. "We want to understand what goes on in the cells when this happens so we can develop better therapies in the future." Wiemann's co-worker, Dr. zgr Sahin, suspects that tiny pieces of RNA known as microRNAs play a role in resistance development. "These minuscule RNA snippets control many cellular processes by attaching themselves to target gene transcripts and thus repressing protein production."

By treating breast cancer cells in vitro with regular doses of tamoxifen, Sahin's team induced resistance of these cells to the drug. As resistance developed, the cancer cells switched to the development program that makes them grow even more invasively and more malignantly. Checking the complete spectrum of microRNAs in the resistant tumor cells, the investigators noticed that production of microRNA 375 was more strongly reduced than others. When they boosted the production of microRNA 375, the cells started responding again to tamoxifen and switched back to their normal growth program. "This strongly suggests that a lack of microRNA 375 both increases malignancy and contributes to resistance development," says zgr Sahin.

If microRNA 375 levels are low, breast cancer cells increase the production of metadherin. Apparently, microRNA 375 suppresses the production
'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists identify novel inhibitor of human microRNA
2. MicroRNAs grease the cells circadian clockwork
3. MicroRNAs help control HIV life cycle
4. MicroRNA in human saliva may help diagnose oral cancer
5. Scientists use microRNAs to track evolutionary history for first time
6. Penn biologists determine microRNA activity is suppressed in mouse ovum
7. Pitt researchers discover big role for microRNA in lethal lung fibrosis
8. MicroRNA network study implicates rewired interactions in cancer
9. Study of microRNA helps NIH scientists unlock secrets of immune cells
10. Red blood cells have a tiny but effective protector -- microRNA
11. Newly identified RNA sequence is key in microRNA processing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... a healthy source of protein, that,s not why the Millennials ... presented at Tops Club Inc.,s annual International Recognition Days convention ... 20-something women who want dishes that are quick, easy to ... basically seem to care less about any health benefits of ... to look good and because it,s quick to cook and ...
(Date:7/9/2014)... studies suggest that children delivered by Caesarean section have a ... it is still unknown why this is the case and ... Faculty of Health and Medical Sciences therefore decided to scrutinise ... system in a study of newborn mouse pups. ... section had developed a lower number of cells that strengthen ...
(Date:7/9/2014)... for another in a line of living stem cells ... this decade. As with any new technology, it brings ... in humans, for example--as well as questions and safety ... concerns to rest: using gene-editing techniques on stem cells ... cells. The new results were published July 3 in ...
Breaking Biology News(10 mins):Mouse study: Natural birth may strengthen the immune system 2No extra mutations in modified stem cells, study finds 2No extra mutations in modified stem cells, study finds 3
... Institute for Medical Research today unveiled a collaboration with ... (MIT) being spearheaded by GlaxoSmithKline (GSK), which aims to ... body,s organs and functions. This initiative is discussed in ... is a powerful collaboration between leaders in the field ...
... from turtles, and scientists who have just sequenced the first ... the shelled creatures, remarkable longevity and ability to survive for ... turtles use to protect their heart and brain from oxygen ... stroke, the researchers said. UCLA conservation biologist ...
... April 9, 2013 Many terrestrial animals are frequently observed ... a lion kill in the Serengeti or a buzzard swooping ... activity in the oceans is especially difficult, and often overlooked ... published in PLOS ONE titled, " White sharks ...
Cached Biology News:Feinstein Institute collaborates with GSK, UPenn, MIT to research body's electrical impulses 2Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations 2Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations 3Great white sharks 2
(Date:1/15/2014)... Jan. 15, 2014  Bill Jacobs Automotive, a group of car ... up with the Heartland Blood Center and offering free oil ... drive takes place Saturday, Jan. 18 at the Bill Jacobs ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal ... been selected by Buffalo BioBlower Technologies LLC ("B3") as ... SBIR Phase 2 award from the Army Corps of ... system that kills all biological contaminants and destroys VOCs ...
(Date:1/15/2014)... Cynvenio, a cancer diagnostics company focused ... analysis of tumor cells in the bloodstream, today announced ... decision support application powered by CollabRx, Inc. , ... test, Therapy Finder will provide breast cancer patients and ...
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3
... , , KENILWORTH, N.J., July ... results for the 2009 second quarter. , , ... have given us the strength to again power through tough challenges - ... said Fred Hassan, chairman and CEO. , , ...
... ... Accreditation and Compliance Excellence Solution , ... San Francisco, CA (PRWEB) July 21, 2009 -- Quantros, a leading ... industry , announced today the highly positive results East Jefferson General Hospital (EJGH) has ...
... ... Europe, Canada, and Russia requiring confidential, direct buyer representation for a ... Board Certified real estate attorney and Lic. Real Estate Broker, Christian ... broker and real estate attorney exclusively for premium property buyers, greatly ...
Cached Biology Technology:Schering-Plough Reports Financial Results for 2009 Second Quarter 2Schering-Plough Reports Financial Results for 2009 Second Quarter 3Schering-Plough Reports Financial Results for 2009 Second Quarter 4Schering-Plough Reports Financial Results for 2009 Second Quarter 5Schering-Plough Reports Financial Results for 2009 Second Quarter 6Schering-Plough Reports Financial Results for 2009 Second Quarter 7Schering-Plough Reports Financial Results for 2009 Second Quarter 8Schering-Plough Reports Financial Results for 2009 Second Quarter 9Schering-Plough Reports Financial Results for 2009 Second Quarter 10Schering-Plough Reports Financial Results for 2009 Second Quarter 11Schering-Plough Reports Financial Results for 2009 Second Quarter 12Schering-Plough Reports Financial Results for 2009 Second Quarter 13Schering-Plough Reports Financial Results for 2009 Second Quarter 14Schering-Plough Reports Financial Results for 2009 Second Quarter 15Schering-Plough Reports Financial Results for 2009 Second Quarter 16Schering-Plough Reports Financial Results for 2009 Second Quarter 17Schering-Plough Reports Financial Results for 2009 Second Quarter 18Schering-Plough Reports Financial Results for 2009 Second Quarter 19Schering-Plough Reports Financial Results for 2009 Second Quarter 20Schering-Plough Reports Financial Results for 2009 Second Quarter 21Schering-Plough Reports Financial Results for 2009 Second Quarter 22Schering-Plough Reports Financial Results for 2009 Second Quarter 23Schering-Plough Reports Financial Results for 2009 Second Quarter 24Schering-Plough Reports Financial Results for 2009 Second Quarter 25Schering-Plough Reports Financial Results for 2009 Second Quarter 26Schering-Plough Reports Financial Results for 2009 Second Quarter 27Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance 2Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance 3Miami Beach Real Estate Attorney Opens Miami Real Estate Brokerage for International Luxury Miami Beach Condo Buyers From Distressed Sellers 2Miami Beach Real Estate Attorney Opens Miami Real Estate Brokerage for International Luxury Miami Beach Condo Buyers From Distressed Sellers 3
... in a regulated environment, Pipette Tracker ... software that automates gravimetric pipette calibration ... that meets todays regulatory compliance requirements. ... solution that includes a full security ...
... Detection of the yolk protein Vtg in ... simple and sensitive biomarker for endocrine disrupting chemicals ... Vtg has become an accepted screening test for ... Vtg (rainbow trout) EIA kit is a double-antibody ...
... AAIPharmas Routine Testing Laboratory (RTL) ... developed over 25 years. ,,Microbial method ... used to monitor the conditions of ... quality for manufactured products,,We offer a ...
... whose sequence is from rat SCAMP 5. The sequence of ... - Q - P - Q - T - Q - ... - Y - T - Y - S - N(233). ... with the polyclonal antibody that reacts with this product and the ...
Biology Products: