Navigation Links
Micro-origami: USC folds up micrometer-scale 'voxels' for drug delivery
Date:4/29/2008

Researchers at the USC Information Sciences Institute have demonstrated a way to manufacture miniscule closed containers that might be used to deliver precise micro- or even nano-quantities of drugs.

According to ISI project leader Peter Will, who is also a research professor in the Viterbi School of Engineering, the new technique, described in a paper in the Journal of Micromechanics and Microengineering, is a two-step process.

Part one is the creation of flat patterns, origami, of exactly the fold up shapes familiar to kindergarten children making paper pyramids, cubes or other solids, except that these are as small 40 micrometers (m) on a side. (1 inch = 25,400 m)

Instead of paper, the USC researchers created the patterns in polysilicon sitting on top of a thin film of gold, using a well-established commercial silicon wafer process called PolyMUMPs. The next step was clearing the polysilicon off the hinge areas by etching.

When the blanks were later electrocoated with permalloy to make them magnetic, the photomask used left hinge areas uncoated, to make sure they were the places that folded.

Then the folding had to be accomplished. First the researchers bent the hinges by application of magnetic force to the permalloy. Water pressure and capillary forces generated by submerging the tiny blanks in water, and drying them off did the final folding into shape.

The experiments spend considerable time comparing various methods of controlling the closure effects of water drying with simple flaps designed to close over each other to form "envelops," the directing water from different directions sequence the closing. Varying the time of trying could produce tighter seams.

"Our experiments show" says the paper, that "the combination of partial folding of structures by magnetic actuation and liquid closure to bring the structures to their final closed state is an extremely promising techni
'/>"/>

Contact: Eric Mankin
310-448-9112
University of Southern California
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Fewer babies born after Caesarean delivery
2. Remarks Prepared for Delivery By Attorney General Michael B. Mukasey At the Ministerial Press Conference
3. e-SMART Technologies Continues Delivery of Its New Super SMART Card in South Korea
4. Researchers develop better membranes for water treatment, drug delivery
5. Carnegie Mellon researchers to develop new drug delivery system
6. Computer solution to delivery problem
7. Nanoengineers mine tiny diamonds for drug delivery
8. Jumping genes could make for safer gene delivery system
9. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Micro-origami: USC folds up micrometer-scale 'voxels' for drug delivery
(Date:8/26/2014)... are bringing a touch of color to glucose ... glucose monitoring material that changes color as glucose ... precise that doctors and patients may be able ... - something not possible using current point measurements ... to current continuous glucose monitoring technologies," said study ...
(Date:8/26/2014)... at the University of Illinois at Urbana-Champaign have ... paving the way for power-on-a-chip applications. , ... scale that amplify light and produce ultra-narrowband spectral ... electrical and computer engineering (ECE) at Illinois. "These ... power on a chip containing both electronic and ...
(Date:8/26/2014)... , August 26, 2014 ... Veröffentlichung von Oxygen Forensic Passware Analyst bekannt, ... die preisgekrönten Erfassungs- und Analysetools von Oxygen ... kombiniert.     Das neue Tool ... in einem einzigen nahtlosen Ablauf. Das neu ...
Breaking Biology News(10 mins):A glucose meter of a different color provides continuous monitoring 2A glucose meter of a different color provides continuous monitoring 3Symphony of nanoplasmonic and optical resonators produces laser-like light emission 2Oxygen Forensic Passware Analyst erfasst geschützte Mobilgerätedaten 2
... report describing the occurrence of pesticides in streams and ... are typically present throughout the year in most streams ... are less common in ground water. The report ... to affect humans. However in many streams, particularly ...
... a heart attack does not improve certain cardiac functions ... risk of death, according to a study in the ... widely available dietary supplement and is publicized as having ... sexual dysfunction, according to background information in the article. ...
... L-arginine following a heart attack does not improve certain ... an increased risk of death, according to a study ... is a widely available dietary supplement and is publicized ... failure and sexual dysfunction, according to background information in ...
Cached Biology News:Pesticides in the nation's streams and ground water 2Pesticides in the nation's streams and ground water 3Pesticides in the nation's streams and ground water 4An elephant tail 2Little known DNA repair enzyme may be a tumor suppressor gene 2
(Date:8/26/2014)... 26, 2014 Vycom announced today that ... specializes in chemical process equipment, has selected its Flametec ... Facility for Rare Isotope Beams (FRIB). This involved ... line made with Vycom’s Flametec PVC-C and Kytec PVDF ... essential parts of FRIB’s linear accelerator (known as LINAC). ...
(Date:8/26/2014)... 2014 Trovagene, Inc. (NASDAQ:  TROV) presented ... Moving Assays to the Clinic with an ... Cell Free Tumor DNA in Urine." In this ... Precision Cancer Monitoring (PCM) platform and results from ... detection of tumor DNA mutations from urine samples ...
(Date:8/26/2014)... , Aug. 26, 2014  Guardant Health, a ... of oncology diagnostic products, has been recognized today ... Technology Pioneer . As an innovator in ... 24 companies across a wide variety of industries ... Guardant360 ® , Guardant Health,s first ...
(Date:8/26/2014)... , Aug. 26, 2014 Albany Molecular ... that William S. Marth , President and Chief ... Stanley Global Healthcare Conference on Monday, September 8, 2014 ... audio webcast of the presentation can be accessed at ... The webcast will be archived for 90 ...
Breaking Biology Technology:Modutek Selects Vycom’s Flametec Materials for Michigan State University’s Superconductor Equipment 2Modutek Selects Vycom’s Flametec Materials for Michigan State University’s Superconductor Equipment 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 2Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 4Guardant Health Named a 2015 Technology Pioneer by World Economic Forum 2
... Pipeline-Grade Renewable Natural Gas ... Manure and Other Waste Products, TARRYTOWN, N.Y., June ... leader in the renewable bioenergy industry,will today mark the ... with a ground breaking ceremony. The Dublin, Texas,facility, owned ...
... for,Analytical Cytometry has bestowed its President,s Award for ... work on the discovery and,characterization of embryonic-like stem ... Institute of the University of Louisville and has,employed ... "I am highly honored to have been ...
... WA, June 11 /PRNewswire-FirstCall/ - Oncothyreon Inc.,(Nasdaq: ... that the first,patient has been treated in a ... advanced metastatic cancer. PX-12 is a proprietary small ... molecular,pathways that contribute to the growth, survival and ...
Cached Biology Technology:Environmental Power Holds Ground Breaking Ceremony for Renewable Natural Gas Facility at Rio Leche Estates 2Environmental Power Holds Ground Breaking Ceremony for Renewable Natural Gas Facility at Rio Leche Estates 3Environmental Power Holds Ground Breaking Ceremony for Renewable Natural Gas Facility at Rio Leche Estates 4Environmental Power Holds Ground Breaking Ceremony for Renewable Natural Gas Facility at Rio Leche Estates 5Stem Cell Researcher Wins Award for Excellence for Work With the ImageStream(R) System 2Oncothyreon initiates Phase 1b trial of PX-12 in patients with advanced metastatic cancer 2Oncothyreon initiates Phase 1b trial of PX-12 in patients with advanced metastatic cancer 3
... Clear yellow solution. In ... thimerosal, and other proprietary ... Diluent formulated to stabilize ... antibody conjugates at high ...
... software is used to predict ... DNA sequence up to 3,200 ... placement of primers and GC ... denaturing gradient gel electrophoresis (DGGE), ...
... The Mini-Sub cell GT cell and PowerPac ... gel electrophoresis of nucleic acids in agarose gels. ... tank, lid with cables and electrodes, a 7 ... ruler, two casting gates, and two 1.5 mm ...
... PowerPac basic power supply are used for submerged ... gels. The mini format cell includes a buffer ... bubble. The PowerPac basic power supply, 100-120 and ... mA, and 75 W. Power cord and instructions ...
Biology Products: