Navigation Links
Micro-RNA blocks the effect of insulin in obesity
Date:3/31/2011

gical Research and scientific coordinator of the Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases at the University of Cologne assume, therefore, that micro-RNAs may also play a role in type 2 diabetes. These short ribonucleic acid molecules can regulate the activity of genes and thus control protein production.

The research group in Cologne has now discovered a new mechanism that leads to insulin resistance of the cells. Accordingly, obese mice form excess miRNA-143 in their livers. This RNA molecule silences genes that are responsible for the activation of the enzyme AKT and therefore inhibits insulin from activating AKT. "AKT is important for glucose transport in the cell and for the inhibition of glucose synthesis in the liver. When the enzyme is inhibited, insulin fails to take effect and the blood sugar remains elevated," explains Jens Brning.

For their research study, the researchers compared normal weight mice with obese mice with type 2 diabetes. They discovered that the diseased animals produce more than twice as much miRNA-143 in their livers than the normal ones. Moreover, the researchers found only a low concentration of the protein ORP8 in the obese mice which formed large quantities of miRNA-143. ORP8 stimulates insulin to activate AKT and therefore reduces the sugar content of the blood. If ORP8 is lacking, insulin is unable to take effect and the AKT remains inactive.

The researchers do not yet know why obese mice form more miRNA-143 than their normal weight counterparts. "If we succeed in explaining the signalling paths in the cell that lead to the production of miRNA-143, we will have a starting point for the development of new drugs for the treatment of type 2 diabetes," explains Jens Brning in reference to future research plans.


'/>"/>

Contact: Dr. Cornelia Weigelt
weigelt@nf.mpg.de
49-221-472-6301
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2

Related biology news :

1. New evidence in plants shows micro-RNA can move
2. Morphine blocks tumor growth
3. New arsenic nanoparticle blocks aggressive breast cancer
4. Study shows adding UV light helps form Missing G of RNA building blocks
5. Applied physicists create building blocks for a new class of optical circuits
6. Supplement blocks the initiation of breast cell mutations by estrogens
7. Natural compound blocks hepatitis C infection
8. Vaccine blocks malaria transmission in lab experiments
9. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
10. New study shows you can have your candy and eat it too -- without adverse health effects
11. Satellites show effect of 2010 drought on Amazon forests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 15, 2014 The Defense Logistics ... easier to detect and prevent counterfeit microcircuits from ... the agency started performing an in-house microcircuit anti-counterfeit ... the authenticity of purchased microcircuits while increasing their ... control measures will be conducted at DLA,s Electronics ...
(Date:12/17/2014)...  Automation is fundamentally transforming the travel experience ... international borders. Over the past decade, ePassports, biometric ... travelers to self process through border control via ... an increasing number of airports, seaports, and land ... to Maxine Most , Principal at Acuity ...
(Date:12/11/2014)...  That blood pressure plays a role in human health ... medical term for high blood pressure – was first described ... cuff that,s used in measuring blood pressure was invented in ... about hypertension, its triggers and its effects. In fact, recent ... the best ways to treat it. For example, ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... girls exposed to high levels of the pesticide DDT ... to develop hypertension,when they become adults, according to a ... Previous studies have shown that adults exposed ... pressure. But this study, published online March 12 in, ...
... combination of extreme cold temperatures, man-made chemicals and a ... Arctic ozone hole of 2011, a new NASA study ... undergo ozone losses during the winter, the Arctic,s ozone ... Antarctic,s. This is because the three key ingredients needed ...
... was shown that pumpkins and cucumbers can be traced back ... an understanding of Cucurbitaceae evolution and diversity, a new checklist ... information on that family. The study was published in the ... are essential components of a healthy daily diet, not just ...
Cached Biology News:Prenatal exposure to pesticide DDT linked to adult high blood pressure 2NASA pinpoints causes of 2011 Arctic ozone hole 2NASA pinpoints causes of 2011 Arctic ozone hole 3A new checklist confirms Indian origins of pumpkins and cucumbers 2
(Date:12/24/2014)... December 23, 2014 Nashville Fertility Center ... elected treasurer for the American Society for Reproductive Medicine ... and research in reproductive medicine. In his new ... on the executive board and will have a voice ... Hill has actively supported ASRM since 1984 when he ...
(Date:12/24/2014)... 23, 2014 PharmaBoardroom,s new ... today and available for free download , digs deep ... and growth in the sector today. One area ... has been in developing a homegrown pharmaceutical manufacturing base, even ... still remains some way off. A cursory comparison with neighboring ...
(Date:12/22/2014)... , Dec. 22, 2014   ... a developer of pathogen-specific therapies for serious ... protecting the microbiome, today announced positive topline ... 1a clinical trial of SYN-004, the Company,s ... of Clostridium difficile (C. difficile) ...
(Date:12/22/2014)... The American Journal of Hematology/Oncology, ... reviews and editorials addressing developments and pathways related ... a provocative article exploring the role of follicle-stimulating ... treatment of prostate cancer. , The article ... possibility that there could be a connection to ...
Breaking Biology Technology:Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... John Madison, Wis. The ... to serve as general director for the WiSys ... technologies. , ,Founded in 2000 as a supplementary organization ... of the other 25 UW System campuses by protecting ...
... 2004, Inc. from Sharon Farmer. In the summer of ... meeting between Senator John Kerry and technology executives in Silicon ... of the presidential campaign, and I had no particular interest ... , ,Six months later, I had the opportunity to interview ...
... amid a group of Midwest technology consultants and you want to get ... work for free? Its an amazing thing. , ,You can ply your ... outstanding resume and all you have to do is hang out a ... and asking you to perform your services for no money. , ,When ...
Cached Biology Technology:WiSys new manager plans system-wide research awareness 2John Kerry talks technology 2John Kerry talks technology 3John Kerry talks technology 4Dont work for free on a maybe someday 2Dont work for free on a maybe someday 3Dont work for free on a maybe someday 4
... weight determinations for petroleum-based applications. Multiple solvents can be used, such as water, benzene, formamide, ... ... ... ...
Growth Medium / Media...
... the end of determination; triple-point calibration verification; refrigerator eliminates need for pumps and bath liquid; rapid cooldown; bench-saver ... * Range: 0-3000 mOsm/kg ... ... ...
Request Info...
Biology Products: