Navigation Links
Michigan Tech scientists identify genes linked to Lou Gehrig's disease
Date:9/9/2009

Michigan Technological University researchers have linked three genes to the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig's disease.

Professor Shuanglin Zhang leads the team of mathematicians that isolated the genes from the many thousands scattered throughout human DNA. He notes that their discovery does not mean an end to ALS, but it could provide scientists with valuable clues as they search for a cure.

It can't come any too soon. Zhang started showing symptoms of the disease himself four years ago. He now breathes with support from a respirator and works at home with the aid of a research assistant and his wife, Qiuying Sha, an assistant professor and member of his research team.

"I felt very urgent to find the genes for ALS," he says.

"This is very nice work," said Xiaofeng Zhu, an associate professor of epidemiology at Case Western Reserve University's School of Medicine. "It's very challenging to map genes for complex diseases, and while many statistical methods have been developed, most don't work well in practice. Zhang's group has developed a method to detect genes and gene-gene interaction in complex diseases and provided evidence that it works.

"Their findings will need to be confirmed by other researchers, but I think this will be very useful for the investigators who are trying to find genes underlying complex diseases such as ALS," said Zhu.

According to the ALS Association, only about 10 percent of patients have familial ALS, a directly inherited form of the usually fatal neuromuscular disorder. The remaining 90 percent, including Zhang, are diagnosed with the sporadic form of the disease. While scientists have long suspected that genetics plays a role in sporadic ALS, they have had no evidence to back it up, at least until now.

Everyone has the three genes in question. But in people with sporadic ALS, they differ from those in people who don't have ALS.

The mathematicians were not surprised when they tracked down the genes' street address. "Everybody has 23 chromosomes, and the three genes on chromosomes 2, 4, and 10 interact," explained Sha. "If you have this combination of the three genes, you are at high risk of developing the disease."

"It's really exciting, especially because my husband has sporadic ALS," she adds. "Maybe they can find a cure by blocking the genes."

According to the ALS Association, approximately 30,000 Americans have ALS, and about 5,600 new cases are diagnosed every year. The disease destroys the nerves in the brain and spinal cord that control voluntary movement, eventually leading to paralysis.

Zhang's team used a new statistical method to analyze the genetic codes of 547 individuals, 276 with sporadic ALS and 271 without. Their method, a two-locus interaction analysis approach, allows the researchers to identify multiple genes associated with a complex illness.

The data set they analyzed was provided by National Institute of Neurological Disorders and Stroke (NINDS) Human Genetics Resource Center at the Coriell Institute (http://ccr.coriell.org/ninds), a publicly funded "bank" or repository for human cells, DNA samples, clinical data, and other information that aims to accelerate research on the genetics of nervous system disorders.

"Ideally, we should confirm our results in a second data set, but we don't have one available," Sha says.

ALS is not the first condition they have tackled. Using data sets provided by University of Cambridge, Zhang, Sha and their colleagues have also identified 11 genes linked to type 2 diabetes, which has reached epidemic proportions in the U.S.

The team hopes to apply their methods to other medical conditions, but has been hampered by the lack of genetic information: most data sets are not freely available to researchers. Zhang found out about the ALS data sets serendipitously, while searching the ALS Association website for information on his condition.

"Unfortunately, we don't have access to more data sets," said Sha. "If we did, we could analyze even more diseases."


'/>"/>

Contact: Marcia Goodrich
mlgoodri@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert  

Related biology news :

1. Climate change driving Michigan mammals north
2. University of Michigan installs second Genomatix Genome Analyzer
3. Lake Michigan fish populations threatened by decline of tiny creature
4. Michigan Tech researchers link 11 genetic variations to type 2 diabetes
5. Scientists discover new genetic variation that contributes to diabetes
6. Einstein scientists move closer to a safer anthrax vaccine
7. Scientists begin to untangle root cause of Alzheimers disease
8. NOAA scientists map fish habitat and movements at Grays Reef Marine Sanctuary
9. Scientists study possible responses to climate emergencies
10. Finding the ZIP-code for gene therapy: Scientists imitate viruses to deliver therapeutic genes
11. Caltech neuroscientists find brain region responsible for our sense of personal space
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Michigan Tech scientists identify genes linked to Lou Gehrig's disease
(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree ... products targeting the needs of consumers who are incorporating medical marijuana into their ... Phoenix, Arizona. , As operators of two successful Valley dispensaries, The Giving Tree’s ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. ... to perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s ...
(Date:10/6/2017)... , ... October 06, 2017 , ... ... a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial for ... Dana-Farber Cancer Institute. The event is free and open to the public, but ...
Breaking Biology Technology: