Navigation Links
Michigan Tech scientists identify genes linked to Lou Gehrig's disease
Date:9/9/2009

Michigan Technological University researchers have linked three genes to the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig's disease.

Professor Shuanglin Zhang leads the team of mathematicians that isolated the genes from the many thousands scattered throughout human DNA. He notes that their discovery does not mean an end to ALS, but it could provide scientists with valuable clues as they search for a cure.

It can't come any too soon. Zhang started showing symptoms of the disease himself four years ago. He now breathes with support from a respirator and works at home with the aid of a research assistant and his wife, Qiuying Sha, an assistant professor and member of his research team.

"I felt very urgent to find the genes for ALS," he says.

"This is very nice work," said Xiaofeng Zhu, an associate professor of epidemiology at Case Western Reserve University's School of Medicine. "It's very challenging to map genes for complex diseases, and while many statistical methods have been developed, most don't work well in practice. Zhang's group has developed a method to detect genes and gene-gene interaction in complex diseases and provided evidence that it works.

"Their findings will need to be confirmed by other researchers, but I think this will be very useful for the investigators who are trying to find genes underlying complex diseases such as ALS," said Zhu.

According to the ALS Association, only about 10 percent of patients have familial ALS, a directly inherited form of the usually fatal neuromuscular disorder. The remaining 90 percent, including Zhang, are diagnosed with the sporadic form of the disease. While scientists have long suspected that genetics plays a role in sporadic ALS, they have had no evidence to back it up, at least until now.

Everyone has the three genes in question. But in people with sporadic ALS, they differ from those in people who
'/>"/>

Contact: Marcia Goodrich
mlgoodri@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Climate change driving Michigan mammals north
2. University of Michigan installs second Genomatix Genome Analyzer
3. Lake Michigan fish populations threatened by decline of tiny creature
4. Michigan Tech researchers link 11 genetic variations to type 2 diabetes
5. Scientists discover new genetic variation that contributes to diabetes
6. Einstein scientists move closer to a safer anthrax vaccine
7. Scientists begin to untangle root cause of Alzheimers disease
8. NOAA scientists map fish habitat and movements at Grays Reef Marine Sanctuary
9. Scientists study possible responses to climate emergencies
10. Finding the ZIP-code for gene therapy: Scientists imitate viruses to deliver therapeutic genes
11. Caltech neuroscientists find brain region responsible for our sense of personal space
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Michigan Tech scientists identify genes linked to Lou Gehrig's disease
(Date:5/20/2015)... 2015 Research ... the addition of the  "5-year Opportunity ... Market"  report to their offering.  ,     ... analyses trends in the iris recognition ... sectors, globally. Despite hardware pricing and ...
(Date:5/18/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
(Date:5/11/2015)... -- Curemark LLC, a privately held drug research and ... III double blind, randomized, placebo-controlled clinical trial to examine ... children ages 3-8 with Autism. Previously, Curemark announced the ... clinical trial for CM-AT in children ages 3-8 with ... chymotrypsin. This new trial will help determine whether all ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2
... Mass. (Dec. 15, 2008) Whitehead Institute researchers ... pluripotent stem (iPS) cells, cutting the number of ... to one. Scientists hope that these embryonic stem-cell-like ... ailments as Parkinson,s disease and diabetes. The ...
... and adults with the blood cancer mixed-lineage leukemia (MLL) typically ... first birthdays. Although there are varying causes of MLL, most ... MLL and the AF4 genes. When ... potent cancer-causing oncogene is created. Although researchers have known that ...
... who reminds you to floss might be your cardiologist instead ... a protein associated with inflammation (called CRP) is elevated in ... the inflammation coming from? A new research study by Italian ... shows that infected gums may be one place. Indeed, ...
Cached Biology News:Single virus used to convert adult cells to embryonic stem cell-like cells 2Tracking the molecular pathway to mixed-lineage leukemia 2
(Date:5/28/2015)... , May 28, 2015 Natera, Inc., ... a study published in Ultrasound in Obstetrics ... polymorphism (SNP)-based non-invasive prenatal test (NIPT) can identify ... A study based upon data ... pregnancies occur in about 1 in 1,000 pregnancies, ...
(Date:5/28/2015)... MARLBOROUGH, Mass. , May 28, 2015 ... company focused on discovering and developing innovative therapeutics, primarily ... the pricing of a public offering of 26 million ... per share for gross proceeds of approximately $10.4 million. ... stock, (ii) a 13-month overallotment purchase right to purchase ...
(Date:5/28/2015)... The Fertility Centers of New England is proud ... taken on a new and expanded role as Medical ... leadership, oversight and quality assurance for the practice. , ... team of experienced reproductive endocrinologists,” said Fertility Centers of ... “Her expertise and compassionate, individualized care have helped set ...
(Date:5/28/2015)... American Process Inc. (Atlanta, GA) ... recently signed a joint agreement to ... using nanocellulose, a rapidly emerging high performance, bioderived ... the limited number of feedstock materials available. Traditionally ... printed parts for load bearing applications. , ...
Breaking Biology Technology:First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 3RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 3
... Jeff Cunningham and Lynn Jordan , ... Laboratory, Hopkinton, Massachusetts, USA , ... handling device is an optional accessory to the Sciclone Advanced Liquid Handler ... to single wells or columns of 96 and 384 well microplates for ...
... Geoffrey Grove, Susan Ryan and Ed Alderman ... Department, Caliper Life Sciences, Inc., Hopkinton, MA 01748 , ... The High Volume Head is one of four multi-channel ... architecture of the device includes an array of 96 pistons, which are ...
... 1 and Brent Butler 2 , ... Hopkinton, Massachusetts, USA , ... USA , Introduction , ... commonly carried out using manual pipetting. As the demand for greater throughput of ...
Cached Biology Technology:Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 2Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 3Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 4Precision Testing for the Sciclone Advanced Liquid Handler Z8 Option 5Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 2Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 3Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 4Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 5Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 696 Well Pipetting Precision and Accuracy Using the RapidPlate 96/384 Workstation 296 Well Pipetting Precision and Accuracy Using the RapidPlate 96/384 Workstation 396 Well Pipetting Precision and Accuracy Using the RapidPlate 96/384 Workstation 4
Goat polyclonal to CHMP5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-NKDGVLVDEFGLPQ, corresponding to C terminal amino acids 202-215 of Human CHMP5 Entrez GeneID: ...
...
CD45/CD34 combination 50 tests...
... to ThPok ( Abpromise for all tested ... conjugated to KLH derived from within residues 500 ... the amino acid sequence is proprietary) ... Entrez Gene ID: 51043 ...
Biology Products: