Navigation Links
Michigan Tech scientists identify genes linked to Lou Gehrig's disease
Date:9/9/2009

Michigan Technological University researchers have linked three genes to the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig's disease.

Professor Shuanglin Zhang leads the team of mathematicians that isolated the genes from the many thousands scattered throughout human DNA. He notes that their discovery does not mean an end to ALS, but it could provide scientists with valuable clues as they search for a cure.

It can't come any too soon. Zhang started showing symptoms of the disease himself four years ago. He now breathes with support from a respirator and works at home with the aid of a research assistant and his wife, Qiuying Sha, an assistant professor and member of his research team.

"I felt very urgent to find the genes for ALS," he says.

"This is very nice work," said Xiaofeng Zhu, an associate professor of epidemiology at Case Western Reserve University's School of Medicine. "It's very challenging to map genes for complex diseases, and while many statistical methods have been developed, most don't work well in practice. Zhang's group has developed a method to detect genes and gene-gene interaction in complex diseases and provided evidence that it works.

"Their findings will need to be confirmed by other researchers, but I think this will be very useful for the investigators who are trying to find genes underlying complex diseases such as ALS," said Zhu.

According to the ALS Association, only about 10 percent of patients have familial ALS, a directly inherited form of the usually fatal neuromuscular disorder. The remaining 90 percent, including Zhang, are diagnosed with the sporadic form of the disease. While scientists have long suspected that genetics plays a role in sporadic ALS, they have had no evidence to back it up, at least until now.

Everyone has the three genes in question. But in people with sporadic ALS, they differ from those in people who
'/>"/>

Contact: Marcia Goodrich
mlgoodri@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Climate change driving Michigan mammals north
2. University of Michigan installs second Genomatix Genome Analyzer
3. Lake Michigan fish populations threatened by decline of tiny creature
4. Michigan Tech researchers link 11 genetic variations to type 2 diabetes
5. Scientists discover new genetic variation that contributes to diabetes
6. Einstein scientists move closer to a safer anthrax vaccine
7. Scientists begin to untangle root cause of Alzheimers disease
8. NOAA scientists map fish habitat and movements at Grays Reef Marine Sanctuary
9. Scientists study possible responses to climate emergencies
10. Finding the ZIP-code for gene therapy: Scientists imitate viruses to deliver therapeutic genes
11. Caltech neuroscientists find brain region responsible for our sense of personal space
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Michigan Tech scientists identify genes linked to Lou Gehrig's disease
(Date:7/25/2014)... and some of the smoke from those fires is drifting ... the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the Aqua satellite ... over the Great Lakes region of the United States. ... 23, 2014 (first image feature highlighted below) clearly shows the ... In the image, it is over Manitoba and parts ...
(Date:7/25/2014)... of biomedical engineering at the University of Houston, ... and artificial organ development., "Introduction to Tissue Engineering: ... entering into the field of artificial organ development. ... engineering at UH, served as a series editor ... are other published books on the subject of ...
(Date:7/25/2014)... complex congenital central nervous system disease that is ... tubes during the embryonic phase. Many patients have ... and neurocognitive retardation. Such problems decrease the patients, ... at Ankara Physical Medicine and Rehabilitation Education and ... children with SB, using the Pediatric Evaluation of ...
Breaking Biology News(10 mins):University of Houston researcher publishes textbook on tissue engineering 2
... GAINESVILLE, Fla. --- Imagine a Web site like Facebook, ... post quizzes like "What ,80s song are you?" scientists ... few mouse clicks separating them from information needed for ... $12.2 million National Center for Research Resources grant awarded ...
... , REDWOOD CITY, Calif., Oct. 20 DigitalPersona, ... solutions, today announced that WAND Corporation, a leading ... has integrated DigitalPersona technology into their NextGen POS ... now use fingerprint biometrics to boost cashier accountability ...
... a new approach to prepare ancient DNA with a ... an MU animal scientist, along with a team of ... tree" for cows and other ruminants, going back as ... allow scientists to understand the evolution of cattle, ruminants ...
Cached Biology News:UF receives $12.2 million to establish national network of scientists 2UF receives $12.2 million to establish national network of scientists 3WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 3MU research team establishes family tree for cattle, other ruminants 2
(Date:7/24/2014)... Quantum computers have yet to materialise. Yet, scientists ... making such computers faster. One such approach relies ... controlled by applying an electric field. A new ... coherently coupled quantum dots (TQDs) with electrical impulses ... for example, should TQDs be used as quantum ...
(Date:7/24/2014)... synthetic processes prefer to settle into equilibriuma state ... within the realm of non-equilibrium conditions where new ... energy and phases, such as temperature fluctuations, freezing ... to regulate their body temperature, airplanes to fly, ... , But even though these conditions exist ...
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Genomics and Proteomics Analytical Instruments Market 2014-2018" report ... Genomics is the study of the ... of the structure and functions of proteomes or sets ... and technology. Genomics involves the mapping of genes and ...
(Date:7/24/2014)... Calif. , July 24, 2014 SRI ... contract with the National Institute of Allergy and Infectious ... to conduct preclinical development of potential therapies for HIV ... drugs to treat HIV and AIDS and the complications ... as microbicides for preventing sexual transmission of HIV. ...
Breaking Biology Technology:New approach to form non-equilibrium structures 2Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... Index Shows Stronger Performance in Turbulent EconomyOAKBROOK TERRACE, Ill., ... association representing all segments of the high-tech industry, announced ... (Nasdaq: ILTI ) outperformed the Dow Jones ... (COMP) since its inception in 2008.On May 19, 2008, ...
... announced today that it raised US$650 million in committed ... III, LP. Aisling Capital will invest its third fund ... as well as in businesses that provide drug development, ... With a total of over US$1.6 billion in committed ...
... LONDON, Jan. 7 GlaxoSmithKline plc (LSE/NYSE: ... tender offer by its wholly-owned subsidiary Gemstone Acquisition Corporation ... (Nasdaq: GNLB ). The tender offer expired ... January 6, 2009.The depositary for the tender offer has ...
Cached Biology Technology:NASDAQ OMX AeA Illinois Tech Index Outperforms Market 2NASDAQ OMX AeA Illinois Tech Index Outperforms Market 3Aisling Capital Announces Close of US$650M Life Sciences Fund 2GlaxoSmithKline Successfully Completes Tender Offer for Shares of Genelabs Technologies, Inc. 2
... The Turn & Cast submarine gel systems used gasketed ... the gel in the tank. Turn it back and ... For added convenience, each Turn & Cast tray is ... near the edge of the tray and one in ...
The Holten Safe 2010 Class II Biological Safety Cabinets provide the most ergonomical working condition of comfort while incorporating the latest technology for safety, efficiency and performance....
... a dedicated fluorometer with sensitivity ... of assays in industrial and ... applications. Cell biology, immunology and ... application areas. Robot-friendly hardware and ...
... series of Class II Biological Safety ... certification to the world's highest safety ... the cabinets cannot be adjusted out ... low noise and arm rest ensure ...
Biology Products: