Navigation Links
Michigan Tech researchers link 11 genetic variations to type 2 diabetes
Date:4/1/2008

HOUGHTON, Mich.--Mathematicians at Michigan Technological University have developed powerful new tools for winnowing out the genes behind some of humanitys most intractable diseases.

With one, they can cast back through generations to pinpoint the genes behind inherited illness. With another, they have isolated 11 variations within genescalled single nucleotide polymorphisms, SNPs or snipsassociated with type 2 diabetes.

With chronic, complex diseases like Parkinsons, diabetes and ALS [Lou Gehrigs disease], multiple genes are involved, said Qiuying Sha, an assistant professor of mathematical sciences. You need a powerful test.

That test is the Ensemble Learning Approach (ELA), software that can detect a set of SNPs that jointly have a significant effect on a disease.

With complex inherited conditions, including type 2 diabetes, single genes may precipitate the disease on their own, while other genes cause disease when they act together. In the past, finding these gene-gene combinations has been especially unwieldy, because the calculations needed to match up suspect genes among the 500,000 or so in the human genome have been virtually impossible.

ELA sidesteps this problem, first by drastically narrowing the field of potentially dangerous genes, and second, by applying statistical methods to determine which SNPs act on their own and which act in combination. We thought it was pretty cool, Sha said.

To test their model on real data, Shas team analyzed genes from over 1,000 people in the United Kingdom, half with type 2 diabetes and half without. They identified 11 SNPs that, singly or in pairs, are linked to the disease with a high degree of probability. Their work has been accepted by the journal Genetic Epidemiology and is available online at http://www3.interscience.wiley.com/cgi-bin/abstract/117890704/ABSTRACT .

ELA is used to compare the genetic makeup of unrelated individuals to sort out disease-related genes. The team has also developed another approach, which uses a two-stage association test that incorporates founders phenotypes, called TTFP, that can examine the genomes of family members going back generations.

In the past, researchers have dealt with the nuclear family, parents and children, but this could go back to grandparents, great-grandparents . . . as far back as you want.

The team has published their findings in the European Journal of Human Genetics. An abstract is available at www.nature.com/ejhg/journal/v15/n11/abs/5201902a.html.

Now that theyve developed the software, the analysis is relatively simple, says Sha. But getting the genetic data to work on is not. We dont have the data sets yet to work with, she says, clearly frustrated. Thats the problem with having no medical school.

Those who do have data sets, however, can use the teams software to help find the causeand hopefully, the curesfor a panoply of illnesses. ELA is available in Windows and Linux versions at www.math.mtu.edu/~shuzhang/software.html, and TTFP is available by request.


'/>"/>

Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert

Related biology news :

1. UC San Diego researchers eliminate drug discovery bottleneck
2. Harvard researchers publish MRI images of genes in action in the living brain
3. Researchers use high tech in mold watermark to protect plastic products from piracy
4. Womens health-related scientific findings presented by University of Pittsburgh researchers
5. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
6. Yerkes researchers identify language feature unique to human brain
7. Stanford researchers developing 3-D camera with 12,616 lenses
8. 19 researchers selected as 2008 Leopold Leadership Fellows
9. Researchers discover how stealthy HIV protein gets into cells
10. Researchers at Stockholm University awarded the Descartes prize
11. Wisconsin researchers describe how digits grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free validated ... will showcase its product’s latest features from June 26 to June 30, 2016 ... on Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a division of ... and optimized exclusively for Okuma CNC machining centers at The International Manufacturing Technology ... among several companies with expertise in toolholding, cutting tools, machining dynamics and distribution, ...
Breaking Biology Technology: