Navigation Links
Michigan Tech researchers link 11 genetic variations to type 2 diabetes
Date:4/1/2008

HOUGHTON, Mich.--Mathematicians at Michigan Technological University have developed powerful new tools for winnowing out the genes behind some of humanitys most intractable diseases.

With one, they can cast back through generations to pinpoint the genes behind inherited illness. With another, they have isolated 11 variations within genescalled single nucleotide polymorphisms, SNPs or snipsassociated with type 2 diabetes.

With chronic, complex diseases like Parkinsons, diabetes and ALS [Lou Gehrigs disease], multiple genes are involved, said Qiuying Sha, an assistant professor of mathematical sciences. You need a powerful test.

That test is the Ensemble Learning Approach (ELA), software that can detect a set of SNPs that jointly have a significant effect on a disease.

With complex inherited conditions, including type 2 diabetes, single genes may precipitate the disease on their own, while other genes cause disease when they act together. In the past, finding these gene-gene combinations has been especially unwieldy, because the calculations needed to match up suspect genes among the 500,000 or so in the human genome have been virtually impossible.

ELA sidesteps this problem, first by drastically narrowing the field of potentially dangerous genes, and second, by applying statistical methods to determine which SNPs act on their own and which act in combination. We thought it was pretty cool, Sha said.

To test their model on real data, Shas team analyzed genes from over 1,000 people in the United Kingdom, half with type 2 diabetes and half without. They identified 11 SNPs that, singly or in pairs, are linked to the disease with a high degree of probability. Their work has been accepted by the journal Genetic Epidemiology and is available online at http://www3.interscience.wiley.com/cgi-bin/abstract/117890704/ABSTRACT .

ELA is used to compare the genetic makeup of unrelated individuals to sort out disease-related genes. The team has also developed another approach, which uses a two-stage association test that incorporates founders phenotypes, called TTFP, that can examine the genomes of family members going back generations.

In the past, researchers have dealt with the nuclear family, parents and children, but this could go back to grandparents, great-grandparents . . . as far back as you want.

The team has published their findings in the European Journal of Human Genetics. An abstract is available at www.nature.com/ejhg/journal/v15/n11/abs/5201902a.html.

Now that theyve developed the software, the analysis is relatively simple, says Sha. But getting the genetic data to work on is not. We dont have the data sets yet to work with, she says, clearly frustrated. Thats the problem with having no medical school.

Those who do have data sets, however, can use the teams software to help find the causeand hopefully, the curesfor a panoply of illnesses. ELA is available in Windows and Linux versions at www.math.mtu.edu/~shuzhang/software.html, and TTFP is available by request.


'/>"/>

Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert

Related biology news :

1. UC San Diego researchers eliminate drug discovery bottleneck
2. Harvard researchers publish MRI images of genes in action in the living brain
3. Researchers use high tech in mold watermark to protect plastic products from piracy
4. Womens health-related scientific findings presented by University of Pittsburgh researchers
5. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
6. Yerkes researchers identify language feature unique to human brain
7. Stanford researchers developing 3-D camera with 12,616 lenses
8. 19 researchers selected as 2008 Leopold Leadership Fellows
9. Researchers discover how stealthy HIV protein gets into cells
10. Researchers at Stockholm University awarded the Descartes prize
11. Wisconsin researchers describe how digits grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... MELBOURNE, Fla. , Feb. 1, 2016  Wocket® smart wallet ( ... actor and television personality, Joey Fatone . Las ... and greet fans. --> Las Vegas , ... --> The new video ad was filmed at the ... Joey appeared at the Wocket booth to meet and greet fans. ...
(Date:1/25/2016)... 2016   Unisys Corporation (NYSE: UIS ) today ... (JFK) International Airport, New York City , to ... attempting to enter the United States using ... pilot testing of the system at Dulles last year. ... JFK during January 2016. --> pilot testing of ...
(Date:1/22/2016)... http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ... "Global Biometrics Market in Retail Sector 2016-2020" ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced the ... in Retail Sector 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... DURHAM, N.C. , Feb. 8, 2016 Novan, Inc. ... named Chairman of the Board of Directors of Novan. In addition, ... Directors. North Carolina . ... The Company also announced that it received a total of $32.8 ... December 2015 from its private investor network originating throughout the Research ...
(Date:2/8/2016)... 8, 2016  BioElectronics Corporation (OTC Pink: BIEL), ... today that it is responding to a notice ... Securities and Exchange Commission posted on the agency ... of the Board of BioElectronics Corporation and the ... at The Fuqua School of Business, Duke University.   ...
(Date:2/8/2016)... ... ... Bulk food product inspection systems are specifically designed to ... production process. Despite frequently inspecting loose product prior to packaging, product inspection systems ... of dry powders. , Mettler-Toledo Product Inspection's brand-new white paper entitled "Improving Food ...
(Date:2/8/2016)... , Feb. 8, 2016  NanoViricides, Inc. (NYSE MKT: NNVC) ... CEO, Eugene Seymour , MD, MPH, will present information about ... the Waldorf-Astoria Hotel in New York City . ... be in the Windsor Room at 5:30PM EST. Registered attendees can ... New York City . --> ...
Breaking Biology Technology: