Navigation Links
Michigan Tech researchers link 11 genetic variations to type 2 diabetes
Date:4/1/2008

HOUGHTON, Mich.--Mathematicians at Michigan Technological University have developed powerful new tools for winnowing out the genes behind some of humanitys most intractable diseases.

With one, they can cast back through generations to pinpoint the genes behind inherited illness. With another, they have isolated 11 variations within genescalled single nucleotide polymorphisms, SNPs or snipsassociated with type 2 diabetes.

With chronic, complex diseases like Parkinsons, diabetes and ALS [Lou Gehrigs disease], multiple genes are involved, said Qiuying Sha, an assistant professor of mathematical sciences. You need a powerful test.

That test is the Ensemble Learning Approach (ELA), software that can detect a set of SNPs that jointly have a significant effect on a disease.

With complex inherited conditions, including type 2 diabetes, single genes may precipitate the disease on their own, while other genes cause disease when they act together. In the past, finding these gene-gene combinations has been especially unwieldy, because the calculations needed to match up suspect genes among the 500,000 or so in the human genome have been virtually impossible.

ELA sidesteps this problem, first by drastically narrowing the field of potentially dangerous genes, and second, by applying statistical methods to determine which SNPs act on their own and which act in combination. We thought it was pretty cool, Sha said.

To test their model on real data, Shas team analyzed genes from over 1,000 people in the United Kingdom, half with type 2 diabetes and half without. They identified 11 SNPs that, singly or in pairs, are linked to the disease with a high degree of probability. Their work has been accepted by the journal Genetic Epidemiology and is available online at http://www3.interscience.wiley.com/cgi-bin/abstract/117890704/ABSTRACT .

ELA is used to compare the genetic makeup of unrelated individuals to sort out disease-related genes. The team has also developed another approach, which uses a two-stage association test that incorporates founders phenotypes, called TTFP, that can examine the genomes of family members going back generations.

In the past, researchers have dealt with the nuclear family, parents and children, but this could go back to grandparents, great-grandparents . . . as far back as you want.

The team has published their findings in the European Journal of Human Genetics. An abstract is available at www.nature.com/ejhg/journal/v15/n11/abs/5201902a.html.

Now that theyve developed the software, the analysis is relatively simple, says Sha. But getting the genetic data to work on is not. We dont have the data sets yet to work with, she says, clearly frustrated. Thats the problem with having no medical school.

Those who do have data sets, however, can use the teams software to help find the causeand hopefully, the curesfor a panoply of illnesses. ELA is available in Windows and Linux versions at www.math.mtu.edu/~shuzhang/software.html, and TTFP is available by request.


'/>"/>

Contact: Marcia Goodrich
mtunews@mtu.edu
906-487-2343
Michigan Technological University
Source:Eurekalert

Related biology news :

1. UC San Diego researchers eliminate drug discovery bottleneck
2. Harvard researchers publish MRI images of genes in action in the living brain
3. Researchers use high tech in mold watermark to protect plastic products from piracy
4. Womens health-related scientific findings presented by University of Pittsburgh researchers
5. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
6. Yerkes researchers identify language feature unique to human brain
7. Stanford researchers developing 3-D camera with 12,616 lenses
8. 19 researchers selected as 2008 Leopold Leadership Fellows
9. Researchers discover how stealthy HIV protein gets into cells
10. Researchers at Stockholm University awarded the Descartes prize
11. Wisconsin researchers describe how digits grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Brooklyn, NY (PRWEB) , ... June 24, 2016 , ... ... 15mm, machines such as the Cary 5000 and the 6000i models are higher end ... height is the height of the spectrophotometer’s light beam from the bottom of the ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: