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Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's
Date:7/17/2008

el of PD-associated gastrointestinal (GI) dysfunction. She will use the model to test drugs that can alleviate this 'non-motor' symptom, which might also allow for better delivery of existing drugs such as levodopa that must pass through the GI tract to enter the bloodstream.

The following is a complete list of researchers who were awarded grants under Target Validation 2007. For grant abstracts and researcher bios, visit www.michaeljfox.org.

  • Roger J. Colbran, PhD, and Ariel Deutch, PhD,Vanderbilt University School of Medicine
    "CaMKII as a Therapeutic Target in Parkinson's Disease"

  • Ann M. Graybiel, PhD, Massachusetts Institute of Technology
    "Evaluation of the Striatum-enriched Genes CalDAG-GEF1 and CalDAG-GEF2 as Targets for the Treatment and Prevention of L-DOPA Induced Dyskinesia"

  • Pamela J. McLean, PhD, Massachusetts General Hospital (Harvard University)
    "Hsp90 as a Target for Neuroprotective Agents in Parkinson's Disease"

  • Kalipada Pahan, PhD, Rush University Medical Center
    "NBD Peptides in a Non-Human Primate Model of Parkinson's Disease"

  • Yvette F. Tache, PhD, University of California, Los Angeles
    "Mu Opioid Receptors as a Drug Target for Treating Motor Fluctuations in PD"

  • Malu G. Tansey, PhD, University of Texas Southwestern Medical Center
    "Dopaminergic Neuroprotection by Regulator of G-protein Signaling 10 (RGS10)"

  • Stephen F. Traynelis, PhD, and Stella Papa, MD, Emory University School of Medicine
    "Validation of the NR2D Subunit of the NMDA Receptor as a Therapeutic Target for Parkinson's Disease"

  • Danny G. Winder, PhD, Roger Colbran, PhD, and Eric Delpire, PhD, Vanderbilt University School of Medicine
    "NR2B as a Therapeutic Target in Parkinson's Disease"

  • Benjamin Wolozin, MD, PhD, Boston University School of Medicine
    "SIRT1 Activators as Therap
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Contact: Holly Barkhymer
hbarkhymer@michaeljfox.org
212-509-0995 x242
The Michael J. Fox Foundation for Parkinson's Research
Source:Eurekalert

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