Navigation Links
Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's
Date:7/17/2008

The Michael J. Fox Foundation for Parkinson's Research today announced approximately $2.4 million in total funding to nine research teams under its Target Validation initiative. This annual MJFF program provides intellectual and financial resources to help push potential PD drug targets forward toward clinical trials and ultimately the nearly five million Parkinson's patients worldwide.

"The discovery of a new potential therapeutic target generates great excitement among patients and researchers," said Katie Hood, CEO of The Michael J. Fox Foundation. "But to attract an industry sponsor with the resources and expertise to chaperone it through optimization, preclinical work and ultimately clinical testing, that target needs a critical mass of evidence behind it, demonstrating that it is involved in the disease and that manipulating it impacts symptoms or progression. MJFF's Target Validation program helps accumulate this evidence, reducing the risk of investment for industry and building the case for prioritization of the most promising targets in the pipeline."

Target validation is an essential and historically underresourced phase of drug development in which researchers work to determine whether a molecule or mechanism of interest is a true drug target. While researchers have continued to identify novel targets in recent years through genetic, biochemical and epidemiological studies, a lack of funding for validation studies has long been a major roadblock to the efficient translation of these discoveries into practical therapies that benefit people living with PD.

Projects funded in this cohort of Target Validation awardees fall into three categories: targets for therapies to alleviate symptoms of PD; approaches focused on dyskinesias, the excessive, uncontrollable movements brought on by long-term dopamine replacement therapy; and targets with potential to slow or stop progression of Parkinson's, something no currently approved treatment has been proven to do.

Two investigators will be continuing projects initiated under previous MJFF programs, reflecting the Foundation's desire to keep promising work moving forward quickly. Stephen F. Traynelis, PhD, of Emory University was funded under MJFF's Community Fast Track 2005 initiative to screen small-molecule compound libraries for molecules that inhibit a certain type of brain receptor called the NR2D-containing NMDA receptor in the basal ganglia, a part of the brain involved in Parkinson's disease. His new award will allow him to take this work to the next level, testing these molecules to see if they can reduce PD-like symptoms in rodent models. Kalipada Pahan, PhD, of Rush University is investigating a protein called NF-kB, which is involved in the inflammation process that some believe might trigger or promote continued loss of cells in the Parkinson's brain. Dr. Pahan has already shown that delivering specific inhibitors against NF-kB is neuroprotective in a rodent model of Parkinson's. He will now work to confirm his results in a non-human primate model of PD as the next step toward possible clinical trials.

Other investigators will be looking at various targets for possible relevance to therapeutic strategies for PD. Danny G. Winder, PhD, and Roger J. Colbran, PhD, both at Vanderbilt University and Ann M. Graybiel, PhD, at the Massachusetts Institute of Technology are each investigating new targets for possible roles in the development of dyskinesias. To identify strategies that could protect from loss of brain cells in PD, investigators Pamela J. McLean, PhD, of Massachusetts General Hospital (Harvard University), Malu G. Tansey, PhD, of University of Texas Southwestern Medical Center and Benjamin Wolozin, MD PhD, of Boston University School of Medicine will manipulate various proteins in PD animal models. Finally, Yvette F. Tache, PhD, of the University of California, Los Angeles, has developed a possible rodent model of PD-associated gastrointestinal (GI) dysfunction. She will use the model to test drugs that can alleviate this 'non-motor' symptom, which might also allow for better delivery of existing drugs such as levodopa that must pass through the GI tract to enter the bloodstream.

The following is a complete list of researchers who were awarded grants under Target Validation 2007. For grant abstracts and researcher bios, visit www.michaeljfox.org.

  • Roger J. Colbran, PhD, and Ariel Deutch, PhD,Vanderbilt University School of Medicine
    "CaMKII as a Therapeutic Target in Parkinson's Disease"

  • Ann M. Graybiel, PhD, Massachusetts Institute of Technology
    "Evaluation of the Striatum-enriched Genes CalDAG-GEF1 and CalDAG-GEF2 as Targets for the Treatment and Prevention of L-DOPA Induced Dyskinesia"

  • Pamela J. McLean, PhD, Massachusetts General Hospital (Harvard University)
    "Hsp90 as a Target for Neuroprotective Agents in Parkinson's Disease"

  • Kalipada Pahan, PhD, Rush University Medical Center
    "NBD Peptides in a Non-Human Primate Model of Parkinson's Disease"

  • Yvette F. Tache, PhD, University of California, Los Angeles
    "Mu Opioid Receptors as a Drug Target for Treating Motor Fluctuations in PD"

  • Malu G. Tansey, PhD, University of Texas Southwestern Medical Center
    "Dopaminergic Neuroprotection by Regulator of G-protein Signaling 10 (RGS10)"

  • Stephen F. Traynelis, PhD, and Stella Papa, MD, Emory University School of Medicine
    "Validation of the NR2D Subunit of the NMDA Receptor as a Therapeutic Target for Parkinson's Disease"

  • Danny G. Winder, PhD, Roger Colbran, PhD, and Eric Delpire, PhD, Vanderbilt University School of Medicine
    "NR2B as a Therapeutic Target in Parkinson's Disease"

  • Benjamin Wolozin, MD, PhD, Boston University School of Medicine
    "SIRT1 Activators as Therapy for Parkinson's Disease"


'/>"/>

Contact: Holly Barkhymer
hbarkhymer@michaeljfox.org
212-509-0995 x242
The Michael J. Fox Foundation for Parkinson's Research
Source:Eurekalert

Related biology news :

1. Michael A. Betts, Seasoned Financial Services Executive, Joins CIC Board of Directors
2. American Society for Microbiology honors Michael Bruce Zwick
3. Michael A. Betts, Seasoned Financial Services Executive, Joins CIC Board of Directors
4. Remarks Prepared for Delivery By Attorney General Michael B. Mukasey At the Ministerial Press Conference
5. Neuroscientist Michael Gazzaniga awarded Humboldt Prize
6. Balzan Foundation announces 2007 winners
7. Keck Foundation funds study of biological interactions with nanomaterials
8. Yu receives research funding from the Wallace H. Coulter Foundation
9. PETA awards $120,000 to Duluth Foundation for advancing non-animal tests
10. Simons Foundation awards Emory scientists $3M for autism gene research
11. Arizona State University launches biofuel initiative with BP and Science Foundation Arizona
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... Summit ... (NSCF) to support the development of a patient-specific stem cell therapy for the treatment ... the lab of Dr. Jeanne Loring at The Scripps Research Institute in San Diego, ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... support for Connecticut's innovative, growing companies, today announced the launch of VentureClash ... technology (fintech) companies. , “VentureClash looks to attract the best early-stage ...
(Date:4/27/2016)... ... 27, 2016 , ... Shimadzu Scientific Instruments (SSI) will be ... Business Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products ... can stop by booth 1021 to learn how Shimadzu’s instruments can help improve ...
(Date:4/27/2016)... British Virgin Islands (PRWEB) , ... April 27, ... ... Holding Company Ltd. (d/b/a Biohaven) is pleased to announce the appointment of John Tilton ... he was an Executive Director and one of the founding commercial leaders responsible ...
Breaking Biology Technology: