Engineering Conferences International (ECI) (email@example.com) and the Cell Culture Engineering (CCE) XII Conference (http://www.engconfintl.org/10ac.html) are proud to announce Prof. Michael J. Betenbaugh, as the winner of the 2010 Cell Culture Engineering Award. Mike Betenbaugh (http://www.jhu.edu/chembe/faculty-template/MichaelBetenbaugh.html) is Professor of Chemical and Biomolecular Engineering, at Johns Hopkins University, Baltimore, MD, USA.
Professor Betenbaugh's research has had a large impact on both fundamental and applied aspects of cell culture engineering over the past 20 years. His major contribution to the field is the concept that manipulating a cell's production machinery should be an integral part of the optimization of cell culture systems. He recognized early in his professional career that cell death and post-translational processing of proteins in eukaryotic cells often limits the productivity of insect and mammalian cell expression systems, and he pioneered the application of metabolic engineering to cell culture processes.
The first important area in metabolic engineering he worked on was the re-engineering of the cell's glycosylation machinery aiming for optimal, human-like protein glycosylation.
A second important area of metabolic engineering in cell culture was the manipulation of the apoptotic machinery of the cells in order to delay cell death and thus increase productivity.
His molecular-based approach of cell re-engineering represents a research paradigm that many others in the field have since embraced. Mike and his students have also devised novel analytical methods that enabled researchers to elucidate specific bottlenecks which can then be addressed via metabolic engineering. Also, Mike was one of the earli
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