Navigation Links
Mice with big brains provide insight into brain regeneration and developmental disorders
Date:5/15/2012

Scientists at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa) have discovered that mice that lack a gene called Snf2l have brains that are 35 per cent larger than normal. The research, led by Dr. David Picketts and published in the prestigious journal Developmental Cell, could lead to new approaches to stimulate brain regeneration and may provide important insight into developmental disorders such as autism and Rett syndrome.

Dr. Picketts and his team created the mice to learn more about Snf2l, which is known to play a role in packaging DNA and determining which genes are active versus inactive. They found that the mutant mice were completely normal, except that they had larger brains, more cells in all areas of the brain, and more actively dividing brain stem cells.

"This research represents a fundamental advance in our understanding of how the brain develops, and it also has important practical implications," said Dr. Picketts, Senior Scientist at OHRI and Associate Professor in the Faculty of Medicine at uOttawa. "If we could identify drugs that regulate Snfl2 activity, these could potentially be used to stimulate neural stem cells to help regenerate and repair damage in people who have suffered brain injuries or strokes. We're still at the early stages of this research, but the possibilities are very exciting."

The Snf2l mutant mice are also providing insight into developmental disorders that are associated with changes in brain size. For example, by studying these mice, Dr. Picketts and his team found that Snf2l controls the expression of a gene called Foxg1, which causes the intellectual disability disorder Rett syndrome in some people. While the mutant mice have high levels of Foxg1 and large brains, people with Rett syndrome lack Foxg1 and have small brains. This research shows that Snf2l and Foxg1 work against each other to balance brain size. Autism is also commonly associated with changes in brain size (one third of autistic individuals have a larger brain), however no studies have yet provided a direct link between Snf2l and autism.

"The connections between Snf2l and brain developmental disorders are intriguing," said Dr. Picketts. "We're looking forward to further unravelling these connections and hopefully applying this research to help people who suffer from these conditions."


'/>"/>

Contact: Jennifer Ganton
jganton@ohri.ca
613-614-5253
Ottawa Hospital Research Institute
Source:Eurekalert  

Related biology news :

1. Old and young brains rely on different systems to remember emotional content
2. Rice University psychologist finds womens brains recognize, encode smell of male sexual sweat
3. Our brains make their own marijuana: Were all pot heads deep inside
4. Snakes and how they helped our big brains evolve
5. Monkey brains signal the desire to explore
6. Scientists remove amyloid plaques from brains of live animals with Alzheimers disease
7. Stimulus grant of nearly $9 million to UC San Diego funds big study of young brains
8. Ladder-walking locusts show big brains arent always best
9. Bigger not necessarily better, when it comes to brains
10. New neuroimaging analysis technique identifies impact of Alzheimers disease gene in healthy brains
11. Psychopaths brains wired to seek rewards, no matter the consequences
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mice with big brains provide insight into brain regeneration and developmental disorders
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... at the Pennsylvania Convention Center and will showcase its product’s latest features from ... also be presenting a scientific poster on Disrupting Clinical Trials in The Cloud ...
(Date:6/23/2016)... ... 2016 , ... Velocity Products, a division of Morris Group, ... exclusively for Okuma CNC machining centers at The International Manufacturing Technology Show, IMTS, ... companies with expertise in toolholding, cutting tools, machining dynamics and distribution, Velocity SMART ...
(Date:6/23/2016)... PUNE, India , June 23, 2016 /PRNewswire/ ... culture media market research report to its pharmaceuticals ... company profiles, product details and much more. ... market spread across 151 pages, profiling 15 companies ... now available at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . ...
(Date:6/22/2016)... DUBLIN , June 22, 2016 Research ... and Global Markets" report to their offering. ... $39.4 billion in 2014 from $29.3 billion in 2013. The market ... (CAGR) of 13.8% from 2015 to 2020, increasing from $50.6 billion ... and projected product forecasts during the forecast period (2015 to 2020) ...
Breaking Biology Technology: