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Mice use specialized neurons to detect carbon dioxide in the air
Date:8/16/2007

For mice, carbon dioxide often means danger - too many animals breathing in too small a space or a hungry predator exhaling nearby. Mice have a way of detecting carbon dioxide, and new research from Rockefeller University shows that a special set of olfactory neurons is involved, a finding that may have implications for how predicted increases in atmospheric carbon dioxide may affect animal behavior. The finding is reported in the August 17 issue of the journal Science.

Most olfactory sensory neurons express odorant receptor molecules and reside within the lining of the nasal cavity that detect odors. But a small subset express an enzyme called guanylyl cyclase-D (GC-D). Peter Mombaerts, professor and head of the Laboratory of Developmental Biology and Neurogenetics at Rockefeller, and Andreas Walz, a research associate in Mombaerts' lab, created a strain of mice in which GC-D expressing neurons glow with a green fluorescent protein. These GC-D expressing neurons also project their nerve endings to an unusual structure in the back of the olfactory bulb called necklace glomeruli, which resemble a string of beads.

The Rockefeller team's collaborators in China, led by Minmin Luo at the National Institute of Biological Sciences in Beijing, found that all the GC-D expressing neurons in the olfactory epithelium were activated by exposure to carbon dioxide. Conversely, all the cells in the lining of the nasal cavity that were activated by carbon dioxide are the GC-expressing neurons.

"These findings show that a specialized subsystem has evolved in the mouse to detect carbon dioxide," says Mombaerts.

Carbon dioxide makes up about four-hundredths of one percent of the atmosphere. To determine the threshold for carbon dioxide detection in the mouse, the Beijing team trained mice to lick water when they received a whiff of air with higher levels of carbon dioxide. As the amount of carbon dioxide in the whiffs of air was decreased, the
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Contact: Zach Veilleux
Zach.Veilleux@rockefeller.edu
212-327-8982
Rockefeller University
Source:Eurekalert

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