Navigation Links
Mice have distinct subsystem to handle smell associated with fear
Date:7/23/2012

R proteins in these neurons. They found that while neurons expressing a given olfactory receptor connect to only two glomeruli, neurons that express a given TAAR connect to four to six glomeruli. They also found that while olfactory receptor neurons connect to glomeruli throughout the olfactory bulb, TAAR glomeruli tend to be clustered within an area at the top of the bulb. That area was implicated in instinctual behaviors by previous research.

In another experiment they found that the TAAR axons leading to glomeruli at the top of the bulb express a cell adhesion molecule that is associated with olfactory receptor axons leading only to glomeruli at the bottom part of the olfactory bulb.

What convinced Barnea and his colleagues that TAAR neurons constitute an olfactory subsystem were differences in how these neurons choose the receptor gene that they express. They used mice in which one TAAR gene is swapped with a marker that turns the cell blue. When the same strategy was used in olfactory receptor-expressing neurons, the blue marker was switched off and another olfactory receptor gene was selected. By contrast, TAAR-expressing neurons did not turn off the blue marker. They selected another TAAR gene, but continued to be stained blue.

This observation led Barnea and longtime collaborator Stavros Lomvardas of the University of CaliforniaSan Francisco to identify several other differences between TAAR neurons and olfactory receptor neurons in how the neurons carry out gene expression.

"The logic of gene choice in TAAR neurons is different," Barnea said. "Their patterns of projection [to the bulb] are different, and the mechanisms that control their projections are different. Altogether these observations suggest that it's a different subsystem."

The smell of fear?

TAARs were discovered in the nose in 2006 by Stephen Liberles of Harvard Medical School, one of Barnea's collaborators and co-authors of this pape
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Breast cancer in young women: A distinct disease
2. Fine-scale analysis of the human brain yields insight into its distinctive composition
3. Microbe that can handle ionic liquids
4. Mosquitoes -- how we smell is why they bite, research shows
5. A trained palate: Understanding complexities of taste, smell could lead to improved diet
6. Smell and taste experts to discuss new discoveries
7. Modest alcohol intake associated with less inflammation in patients with common liver disease
8. Bartonella infection associated with rheumatoid illnesses in humans
9. Researcher awarded $1 million for stress-associated disease and aging research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mice have distinct subsystem to handle smell associated with fear
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) ... Global Watermarking and Fingerprinting Markets" report to ... This insight provides an overview ... markets. Watermarking aims to control and monitor piracy ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... Prof. Nathan Nelson of Tel Aviv University,s Department ... has been awarded the 2012 Israel Prize in the ... in Jerusalem on the eve of Israel,s Independence Day ... molecular biology, Prof. Nelson is internationally renowned for his ...
... soon become a thing of the past. Instead, with ... painless injection four times a year would be enough. ... and is delivered by an injection into the outer layer ... The nanocarrier will then slowly release the drug over ...
... receive this year,s Charles Rodolphe Brupbacher Prize for Cancer ... of chronic inflammation in the development of tumors. The ... considered one of the highest accolades for cancer researchers ... Thursday in the framework of an international symposium on ...
Cached Biology News:NTU launches new centre to develop new eye-deas for occular therapeutics 2NTU launches new centre to develop new eye-deas for occular therapeutics 3Brupbacher Prize goes to cancer researcher Michael Karin 2
(Date:1/22/2015)... 2015 Selexis SA, a serial innovation ... Banks (RCBs) used for drug discovery to commercial manufacturing, ... include Next-Generation Sequencing (NGS) data packages. The ... manufacturing by ensuring the integrity of the gene, validation ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
(Date:1/22/2015)... 22, 2015  Derma Sciences, Inc. (Nasdaq: ... advanced wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, ... added to the Premier, Inc. Regenerative Skin Grafting ... the AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... Embryo Donation International (EDI), one of the few, ... officially opened today to provide cost-effective embryo donation options ... family.     (Logo: http://photos.prnewswire.com/prnh/20110405/FL76876LOGO) ... number of frozen embryos abandoned or discarded ...
... 2011 Champions Oncology, Inc. (OTC: CSBR) ("the Company", formerly ... the private placement of 12.5 million shares of its common ... gross proceeds to the company of $9.4 million. ... in: Sales resources dedicated to growing its ...
... Caliper Life Sciences, Inc. (NASDAQ: CALP ), ... discovery and life-sciences research, today announced that its Caliper ... research collaboration with Denver-based Catholic Health Initiatives (CHI), one ... health care system,s Center for Translational Research (CTR), which ...
Cached Biology Technology:A New Company Is Born - Embryo Donation International 2Champions Oncology (formerly Champions Biotechnology) Completes $9.4 Million Financing 2Champions Oncology (formerly Champions Biotechnology) Completes $9.4 Million Financing 3Caliper Announces New Oncology Research Collaboration 2Caliper Announces New Oncology Research Collaboration 3
... reports the data from any one of IITC ... recorder. The final data is sent from the ... is automatic for Systolic, Mean, Heart Rate while ... is always in the position to override the ...
... Custom DNA microarrays designed for your specific ... powerful Paraflo microfluidic synthesis platform. Thousands of ... and LC Sciences can provide assistance with ... as part of our comprehensive Custom DNA ...
... RNA aptamer screening and binding optimization and ... microfluidic on-chip synthesis platform. These microarrays are ... Aptamer Microarray Service. Probe Content ... contains greater than 1500 known aptamer sequences. ...
... for RNA aptamer screening and binding optimization ... Paraflo microfluidic on-chip synthesis platform. Thousands of ... on-chip and LC Sciences can provide assistance ... available as part of our comprehensive DNA/RNA ...
Biology Products: