Navigation Links
MiR-137, a new target for post-stroke depression?

MiRNAs likely play an important role in the occurrence and development of depression, and can be used as potential targets for treatment of depression. Studies have shown that miR-137 expression is downregulated in the brain from depression patients with suicidal behavior. Moreover, miR-137 expression is also downregulated in peripheral blood from stroke patients. However, it is not yet known if miRNAs are associated with post-stroke depression. To test this, Dr. Lixia Zhao and colleagues from Shandong Provincial Hospital, China used middle cerebral artery occlusion and chronic mild stress to establish a post-stroke depression model in rats. Compared with controls, the researchers found significantly lower miR-137 levels in the brain and peripheral blood from post-stroke depression rats. Injection of a miR-137 antagonist into the brain ventricles upregulated miR-137 levels, and improved behavioral changes in post-stroke depression rats. Luciferase assays showed miR-137 bound to the 3′UTR of Grin2A, regulating Grin2A expression in a neuronal cell line. Grin2A gene overexpression in the brain of post-stroke depression rats, noticeably suppressed the inhibitory effect of miR-137 on post-stroke depression. Overall, these results, published in the Neural Regeneration Research (Vol. 8, No. 26, 2013), show that miR-137 suppresses Grin2A protein expression through binding to Grin2A mRNA, thereby exerting an inhibitory effect on post-stroke depression. Our results offer a new therapeutic direction for post-stroke depression.


Contact: Meng Zhao
Neural Regeneration Research

Page: 1

Related biology news :

1. Targeting evolution: Could this be the next strategy to stop superbugs?
2. Newly identified proteins make promising targets for blocking graft-vs.-host disease
3. International collaboration finds 11 new Alzheimers genes to target for drug discovery
4. Single mutation gives virus new target
5. Targeted culling of deer controls disease with little effect on hunting
6. Targeting cancers sweet tooth
7. Trovagene Announces Abstracts to be Presented at Molecular Targets and Cancer Therapeutics Conference
8. Search tool for gene expression databases could uncover therapeutic targets, biological processes
9. New target to fight HIV infection identified
10. Target 2 forms of iron to control cystic fibrosis lung infection
11. UC Davis researchers discover molecular target for the bacterial infection brucellosis
Post Your Comments:
(Date:9/29/2015)... -- News facts: , ... , Minimized design shrinks PC footprint , ... embedded Fujitsu PalmSecure authentication enable enterprises to realize benefits ... that good things come in small packages, with the ... desktop and mobile portfolio. Featuring workplace design that favors ...
(Date:9/28/2015)... YORK , Sept. 28, 2015  The ... respiration rate and body temperature, is an essential ... can be indicators of deterioration in a patient,s ... hospital, vital signs are typically taken during routine ... hours. If a patient deteriorates between these observation ...
(Date:9/28/2015)... Synaptics Inc. (NASDAQ: SYNA ), the ... Lenovo has selected Synaptics , Natural ID ™ ... smartphone, the Vibe P1. The new Vibe P1 ... and provide swift access to applications and mobile payments ... FS4202 sensor solution utilizes AES256-bit encryption of the fingerprint ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... the United States , ... represents about 14% of all new cases of kidney cancer.   ... Canada and Europe .  PRCC represents ... --> Hutchison China MediTech Limited ("Chi-Med") (AIM: HCM) today announces ... AB (publ) ("AstraZeneca") have completed enrolment in a global Phase II ...
(Date:10/12/2015)... 2015  MiMedx Group, Inc. (NASDAQ: MDXG ), ... and patent-protected processes to develop and market advanced products ... Sports Medicine, Ophthalmic, and the Dental sectors of healthcare, ... filed against the Company has been dismissed by the ... and CEO, stated, "As we suspected, this case was ...
(Date:10/12/2015)... 12, 2015 cell surface marker detection ... 2022, according to a new report by Grand View Research, ... in incidence of oncology diseases and other cell-associated disorders. ... to reach USD 6.49 billion by 2022, according to a ... demand can be attributed to rise in incidence of oncology ...
(Date:10/12/2015)... DIEGO , Oct. 12, 2015  Patara ... debilitating allergic and inflammatory diseases and conditions, today ... A preferred stock financing. Concurrent with the close ... entered into a Loan and Security Agreement with ... up to $7 million. Patara will use the ...
Breaking Biology Technology: