Dr Andrew Johnson is speaking today (12 July) at the UK National Stem Cell Network annual conference. He and his team from the University of Nottingham have been using a Mexican aquatic salamander called an axolotl to study the evolution and genetics of stem cells - research that supports the development of regenerative medicine to treat the consequences of disease and injury using stem cell therapies. This team has found that there are extraordinary similarities in the development of axolotls and mammals that provide unique opportunities to study the properties of embryonic stem cells and germ cells. These findings are underpinned by a novel theory of evolution that unifies the diversity of mechanisms in animal developmental into a single conceptual framework.
Dr Johnson said "We've produced evidence that pluripotency the ability of an embryonic stem cell to become absolutely any kind of cell is actually very ancient in evolutionary terms. Even though received wisdom is that it evolved with mammals, our research suggests that it was there all along, just not in many of the species that people use in the lab. In fact, pluripotent cells probably exist in the embryos of the simple animals from which amphibians evolved.
"Axolotls, unlike many of the frogs, fish, flies and worms that are used in the lab, have pluripotent cells in their embryos that are the equivalent to those found in embryos from mammals, in that they can produce germ cells, in addition to somatic cells, a property known as ground-state pluripotency. And from a practical perspective, axolotl embryos will provide a very useful tool for understanding how to manipulate embryonic stem cells for modern regenerative medicine."
Axolotls are salamanders that retained primitive characteristics of the first amphibians, the animals descended from fish that moved onto land about 385 million years ago. These early amphibians were the ancestors of every land dwelling vertebrate, in
|Contact: Nancy Mendoza|
Biotechnology and Biological Sciences Research Council