Navigation Links
Methylation signaling controls angiogenesis and cancer growth
Date:11/28/2013

(Boston) A study led by researchers at Boston University School of Medicine (BUSM) demonstrates a new mechanism involving a signaling protein and its receptor that may block the formation of new blood vessels and cancer growth. The findings are published in the December issue of Science Signaling.

Angiogenesis creates new blood vessels in a process that can lead to the onset and progression of several diseases such as cancer and age-related macular degeneration.

Vascular endothelial growth factor (VEGF) is a signaling protein produced by damaged cells, which binds to one of its receptors VEGFR-2, located on the surface of blood vessel cells. Once VEGF is bound to its receptor, it is activated and sends a biochemical signal to the inside of the blood vessel cell to initiate angiogenesis. There are currently multiple Federal Drug Administration-approved medications that target this process. However these medications are limited by insufficient efficacy and the development of resistance.

The researchers demonstrated that a biochemical process called methylation, which can regulate gene expression, also affects VEGFR-2, and this can lead to angiogenesis. Using multiple methods, the researchers were able to interfere with the methylation process of VEGFR-2 and subsequently block angiogenesis and tumor growth.

"The study points to the methylation of VEGFR-2 as an exciting, yet unexplored drug target for cancer and ocular angiogenesis, ushering in a new paradigm in anti-angiogenesis therapy," said Nader Rahimi, PhD, associate professor of pathology, BUSM, who served as the study's senior investigator.


'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. The secret of DNA methylation
2. The first ant methylomes uncover the relationship between DNA methylation and caste differentiation
3. mTOR: A key brain signaling mechanism for rapidly acting antidepressants
4. New book on Signaling by Receptor Tyrosine Kinases by Cold Spring Harbor Laboratory Press
5. Scientists construct visual of intracellular zip code signaling linked to learning, memory
6. Memorial Sloan-Kettering researchers develop new method for tracking cell signaling
7. Structure of cell signaling molecule suggests general on-off switch
8. Signaling pathway linked to fetal alcohol risk
9. FASEB SRC announces conference: TGF-β Superfamily: Signaling in Development & Disease
10. FASEB SRC announces conference registration open for: NAD Metabolism & Signaling
11. FASEB SRC announces conference registration open for: Histone Deacetylases, Sirtuins, and Reversible Acetylation in Signaling and Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... DUBLIN , Dec 16, 2016 Research ... Access System Market - Global Forecast to 2021" report to ... ... projected to grow at a CAGR of 14.06% from 2016 to ... 2016, and is projected to reach 854.8 Million by 2021. The ...
(Date:12/15/2016)... Germany , December 15, 2016 ... today announced an agreement with NuData Security, an award-winning ... The partnership will enable clients to focus on good customer ... data protection regulation. ... In order to provide a one-stop fraud prevention ...
(Date:12/15/2016)... ... announced the addition of the "Global Military Biometrics Market 2016-2020" ... military biometrics market to grow at a CAGR of 7.5% during the ... an in-depth market analysis with inputs from industry experts. The report covers ... report also includes a discussion of the key vendors operating in this ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... La. (PRWEB) , ... January 11, 2017 , ... ... European business development professional has joined its team. Bernhard Bartylla will lead European ... “We’re working with Bernhard to introduce ACOMP and ARGEN to European manufacturers and ...
(Date:1/11/2017)... 2017 AnaptysBio, Inc., a clinical-stage biotechnology ... unmet medical needs in inflammation, today announced the ... financial officer.  Mr. Piscitelli will play a key ... overseeing the company,s accounting and SEC reporting functions. ... Dominic to the senior management team at AnaptysBio," ...
(Date:1/11/2017)... MINNEAPOLIS , Jan. 11, 2017 ... today announced that it has partnered with the ... life science research and diagnostics. The partnership was ... soluble form of receptor for advanced glycation end ... support subject selection for clinical trials in emphysema. ...
(Date:1/11/2017)... ... January 11, 2017 , ... Enabling ... technologies, with on premise functionality, from the cloud. MacDonald-Miller Facility Solutions, a Seattle, ... their existing Microsoft Office 365 E5 licensing to its maximum potential. The firm ...
Breaking Biology Technology: