Navigation Links
Methadone even at therapeutic levels can kill
Date:1/9/2008

PORTLAND, Ore. Methadone is a possible cause of sudden cardiac death even when it isnt overdosed but is taken at therapeutic levels primarily for relief of chronic pain or drug addiction withdrawal, a new study by Oregon Health & Science University researchers suggests.

The studys findings, described in the January 2008 issue of The American Journal of Medicine, are based on an evaluation of all sudden cardiac deaths in the greater Portland, Ore., metropolitan area between 2002 and 2006 where detailed autopsies were performed.

The analysis was based on a comparison of two case groups. One group consisted of 22 sudden cardiac deaths in which toxicology screens turned up 1 milligram or less of methadone defined as a therapeutic level. These cases were compared with a second group of 106 cases where no evidence of methadone was found. Seventeen of the first case group of 22 or 77 percent had no significant cardiac abnormalities, while five had evidence of significant coronary artery disease. By contrast, 60 percent of the case group where no methadone was present had identifiable evidence of cardiac disease or structural abnormalities, all of which are established potential causes of sudden cardiac death.

The unexpectedly high proportion of otherwise unexplained sudden deaths in the therapeutic methadone group points to a significant contribution of this drug toward the occurrence of sudden cardiac death among these patients, said Sumeet Chugh, M.D., lead investigator, director of OHSUs Cardiac Arrhythmia Center, and associate professor of cardiovascular medicine in the OHSU School of Medicine.

The findings lend support to a growing body of individual case reports linking methadone to a rare ventricular arrhythmia, known as torsade de pointes, which can degenerate into ventricular fibrillation leading to sudden death in the absence of medical intervention.

The studys authors conceded that they could not rule out the
'/>"/>

Contact: Harry Lenhart
lenharth@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
2. Potential new therapeutic molecular target to fight cancer
3. The endocannabinoids: Functional roles and therapeutic opportunities
4. Using evolution, UW team creates a template for many new therapeutic agents
5. Dartmouth researchers alarmed by levels of mercury and arsenic in Chinese freshwater ecosystem
6. Manure management reduces levels of antibiotics and antibiotic resistance genes
7. Even minute levels of lead cause brain damage in children
8. Wildfire drives carbon levels in northern forests
9. Folic acid lowers blood arsenic levels in Bangladesh
10. Study finds that even aloof husbands have lower testosterone levels than unmarried men
11. Folic acid lowers blood arsenic levels, according to Mailman School of Public Health study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 26, 2015 The Granite Club, ... and athletic club, today announced it has implemented a ... of movement for members and staff, while restricting access ... process, we selected FST,s IMID Access system because it ... our members and staff, in addition to unparalleled security," ...
(Date:3/24/2015)... , March 24, 2015   Crossmatch ... solutions, today announced that its U.are.U ® ... retailer Goorin Bros . to achieve PCI ... solution secures access to the POS terminal, protecting ... risk of data breaches. With ...
(Date:3/23/2015)... Conn. , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces its ... new advertising campaign on CNBC television starting March 30 th ... will commence airing in New York ... Officer said: "We are excited about our new ad campaign ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... EMBO today announces the selection of seven scientists as ... will assist the researchers to relocate and set up ... "The EMBO Installation Grants directly support young scientists ... Wallon, Installation Grants Programme Manager and EMBO Deputy Director. ...
... bioprocessing engineers with Kansas State University,s Advanced Manufacturing Institute ... removes phosphorus from wastewater and addresses environmental regulations. ... an important environmental problem. It can pollute water resources ... in many Kansas lakes and reservoirs this summer. ...
... This press release is available in German ... Foundation) will establish eight Collaborative Research Centres (CRC) as of ... Committee at its autumn meeting in Bonn. The new CRCs ... 20 percent programme allowance for indirect project costs) in their ...
Cached Biology News:Benefits abound with recently patented system that reduces phosphorus in wastewater 2Benefits abound with recently patented system that reduces phosphorus in wastewater 3DFG to fund 8 new collaborative research centers 2DFG to fund 8 new collaborative research centers 3DFG to fund 8 new collaborative research centers 4DFG to fund 8 new collaborative research centers 5
(Date:3/27/2015)... SHANGHAI , March 27, 2015 ... a leading open-access R&D capability and technology platform ... device industries, announced today that an Investigational New ... monoclonal antibody for rheumatoid arthritis has been accepted ... Administration (CFDA).  In September 2012, ...
(Date:3/27/2015)... Governor Andrew M. Cuomo today announced the ... the world’s largest business idea competition with $5 million ... million, six $500,000 awards and four $250,000 awards. The ... for prizes that will turn ideas with high growth ... region. , "Last year's successful 43North competition brought ...
(Date:3/26/2015)... 26, 2015 PRC Clinical, a Silicon-Valley ... several management and executive appointments effective immediately. , Mike ... (CFO) and member of the Board of Directors. Daniel ... and Sue Dowden will assume the position of Senior ... Chief Operations Officer (COO), has been appointed to the ...
(Date:3/26/2015)... 26, 2015 The Market Element LLC, ... strategic alliance with Designing Gig LLC to provide website ... , “Forging this alliance with Designing Gig represents ... can extend a comprehensive, end-to-end, digital solution for our ... execution,” said Chuck Miller, president of The Market Element. ...
Breaking Biology Technology:Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2
... isn,t a very powerful force, but it matters for small ... Nanowires are so tiny that a human hair would ... meter. Because of their small size, surface tension that occurs ... This is a problem because the wires are seen as ...
... July 21 The Lucian Leape Institute at ... discussion and special evening program at its Third Annual ... .  David Blumenthal, M.D., M.P.P., will deliver a keynote address ... as a patient safety lever and the focus placed on ...
... N.C. , July 21 Chimerix, Inc., a biotechnology ... its clinical management team with the appointment of Timothy King ... MD, as Vice President of Clinical Research.   , ... In these new roles, Mr. ...
Cached Biology Technology:Engineering researchers simplify process to make world's tiniest wires 2David Blumenthal, HHS National Coordinator for Health Information Technology, to Speak at Lucian Leape Institute Third Annual Forum & Gala on Sept. 16 2David Blumenthal, HHS National Coordinator for Health Information Technology, to Speak at Lucian Leape Institute Third Annual Forum & Gala on Sept. 16 3David Blumenthal, HHS National Coordinator for Health Information Technology, to Speak at Lucian Leape Institute Third Annual Forum & Gala on Sept. 16 4Chimerix Appoints Two New Vice Presidents to Clinical Management Team 2Chimerix Appoints Two New Vice Presidents to Clinical Management Team 3
Mouse NOV/CCN3 Affinity Purified Polyclonal Ab...
HiTrap NHS-activated HP, 1 x 5 ml. Category: Chromatography Systems & Accessories, Systems....
Human CXCL14/BRAK Affinity Purified Polyclonal Ab...
mIGSF4A Aff Pur PAb...
Biology Products: