Navigation Links
Meth exposure in young adults leads to long-term behavioral consequences
Date:8/14/2007

WASHINGTON, DC August 13, 2007 Young adults who use methamphetamine may be more vulnerable to age-related brain degeneration when they grow older, new animal research suggests.

The emergence of behavioral deficits in animals months after methamphetamine discontinuation may be relevant to human methamphetamine abusers, says Nora Volkow, MD, director of the National Institute for Drug Abuse. It suggests that even though their current use may not result in deficits, as they age these deficits will become manifest. Volkow did not participate in the study.

The new work examines the idea that methamphetamine puts young users at risk of developing deficits later in life that are symptomatic of Parkinsons disease in individuals with depletion of glial derived neurotrophic factor (GDNF), a protein that protects and repairs dopamine in areas of the brain related to movement control. Loss of nerve cells that produce dopamine is a major factor in the disease.

In their work, published August 15 in The Journal of Neuroscience, Jacqueline McGinty, PhD, at the Medical University of South Carolina, and her colleagues examined the role of GDNF in mice. At 2.5 months of age, the equivalent of adolescence in humans, mice with a partial GDNF gene deletion were compared to mice without the gene deletion; both were given either methamphetamine or saline injections four times over an eight-hour period. McGintys team discovered that the effects of this methamphetamine binge were exacerbated in the mice with the GDNF deletion. In addition, at 12 months, the GDNF-depleted mice moved significantly less than genetically normal mice treated with methamphetamine.

Methamphetamine intoxication in any young adult may have deleterious consequences later in life, although they may not be apparent until many decades after the exposure, says McGinty. These studies speak directly to the possibility of long-term public health consequences resulting from the current epidemic of methamphetamine abuse among young adults.

Future studies might involve identifying the reasons for increased vulnerability to methamphetamine in GDNF-depleted mice in order to help minimize the harm methamphetamine causes to the brain..


'/>"/>
Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
Source:Eurekalert

Related biology news :

1. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
2. Any exposure to tobacco smoke during pregnancy is risky
3. Scalpel-free surgery could reduce risk of HIV and hepatitis exposure for health care workers
4. Prenatal exposure to famine increases risk of schizophrenia
5. Prenatal exposure to marine toxin causes lasting damage
6. Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
7. Exposure to volcanic mineral associated with increased mesothelioma incidence in Turkey
8. Prenatal nicotine exposure reduces breathing response of newborns...
9. Nicotine exposure during development leads to hearing problems
10. Bird brains shrink from exposure to contaminants
11. Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... 20, 2016  VoiceIt is excited to announce ... By working together, VoiceIt and VoicePass ... and VoicePass take slightly different approaches to voice ... security and usability. ... new partnership. "This marketing and technology ...
(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com ... just published the overview results from the Q1 wave ... the recent wave was consumers, receptivity to a program ... data with a health insurance company. "We ... to share," says Michael LaColla , CEO of ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... , ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension ... are higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... bottom of the cuvette holder. , FireflySci has developed several Agilent flow cell ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the launch of the Supplyframe Design Lab . Located in Pasadena, Calif., ... the future of how hardware projects are designed, built and brought to market. ...
Breaking Biology Technology: