Navigation Links
Metastatic movements in 3-D
Date:10/5/2008

Caswell et al.report in the Journal of Cell Biology how the altered behavior of integrins can prompt metastatic movement in tumor cells.

On 2D surfaces, cells may migrate randomly, or be strongly unidirectional. Integrins, which link the cell to the extracellular matrix, are known to influence the mode of migration, but exactly how has been unclear. Recent work has suggested that an integrin called a5b1 drives random movement, while an integrin called avb3 has been associated with unidirectional migrationthe balance of activity between the two determining the type of movement. To further explore the contribution of a5b1 to random migration, the authors thus blocked avb3.

The treated cells changed their mode of migration from unidirectional to random, and their ability to invade 3D gels increased. The changed behavior correlated with an increase in trafficking of a5b1 from intracellular compartments to anterior membrane protrusions. But this increase in trafficking did not significantly alter a5b1's contribution to cell adhesionthe ease with which cells were dislodged from a spinning disk increased as the amount of avb3 was reduced, but was not correlated with any change in a5b1. This suggested that the cells' increased invasive ability was due to alteration in some other property. That property turned out to be activation of a proinvasive pathway headed by a kinase called Akt.

In avb3-blocked cells, a5b1 became associated with epidermal growth factor receptor 1 (EGFR1), which increased EGFR1's abundance at the membrane protrusions, as well as its autophosphorylation. Because EGFR1 is an activator of the Akt pathway, hey presto, the cells took on some new moves.


'/>"/>

Contact: Sati Motieram
motierd@mail.rockefeller.edu
212-327-8581
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. $2.7 million awarded for metastatic colon cancer research
2. Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors
3. Population movements and money remittances spur forest regrowth
4. Paleozoic sediment curve provides new tool for tracking sea-floor sediment movements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
(Date:3/24/2017)... 24, 2017 Research and Markets has announced ... Analysis & Trends - Industry Forecast to 2025" report to ... The ... a CAGR of around 15.1% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... DuPont Pioneer today ... website (openinnovation.pioneer.com) dedicated to connecting third-party innovators with DuPont Pioneer scientists ... breeding, enabling technologies, biologicals and digital solutions. , “DuPont Pioneer is building on ...
(Date:7/15/2017)... NY (PRWEB) , ... July 15, 2017 , ... ... over 5 years. During this time, the people at FFS have learned that ... their customers, engineers at FFS are able to launch new products to meet the ...
(Date:7/14/2017)... ... July 13, 2017 , ... LGC ... kit has received US FDA 510 (k) clearance for use on Siemens Sysmex® ... D-Dimer. Each VALIDATE® D-Dimer kit, prepared using the CLSI EP06-A “equal delta” sample ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... ... URAC accreditation in Specialty Pharmacy. URAC is the independent leader in promoting healthcare ... demonstrated a comprehensive commitment to quality care, improved processes and better patient outcomes. ...
Breaking Biology Technology: