Navigation Links
Metastatic bone disease patients can walk in Lazarus' footsteps
Date:3/9/2009

SAN DIEGO, Calif. (March 9, 2009)Osteoplastya highly effective minimally invasive procedure to treat the painful effects of metastatic bone disease by injecting bone cement to support weakened bonesprovides immediate and substantial pain relief, often presenting individuals who are suffering terribly with the miraculous so-called "Lazarus effect," according to researchers at the Society of Interventional Radiology's 34th Annual Scientific Meeting. Interventional radiologists often couple osteoplasty with heat or cold treatments to kill tumor nerves, if needed.

"The immediate good clinical results observed in our patients should encourage more widespread application of this palliative interventional radiology treatment," said Giovanni C. Anselmetti, M.D., interventional radiologist at the Institute for Cancer Research and Treatment in Turin, Italy. "A patient's quality of life can be severely affected when they have metastatic bone disease. Normal daily activities can become difficult when the metastases become painful, and many patients report that their sleep patterns change, appetite diminishes and the need to take pain relief medications increases," he noted. "Osteoplasty is not a first-line treatment. It is a highly effective minimally invasive procedure that provides pain relief for patients not responding to conventional pain medication treatments," he said. "Metastatic bone disease patientswho have no other options, who are in pain, who have short life expectancies and who have dismal quality of lifeshould be referred to interventional radiologists for osteoplasty treatment. Interventional radiologists can improve the quality of life for patients who have very large metastases and who are going to die because of their primary cancers," added Anselmetti.

Metastatic bone disease is a painful condition that can develop in conjunction with cancers of the breast, bladder, kidney, lung or other organs. It occurs when cancer cells at an original site metastasize or travel to the bone. These metastases can become widespread throughout the skeletal system. Some bone metastases become painful because the tumor eats away at the bone (ostelolysis), creating holes that make the bone thin and weak. As the bones are replaced with tumor, nerve endings in and around the bone send pain signals to the brain and the bone loses its functional strength. If left untreated, bone metastases can eventually cause the bone to fracture and seriously affect a patient's quality of life. Each year, about 100,000 cases of bone metastasis are reported in the United States.

In treating cancer patients with painful bone metastases, interventional radiologists may also use radiofrequency ablation (RFA) or cryoablation. These treatments use heat or cold to desensitize the bone by killing the nerve endings in the vicinity of the metastasis. Once the nerve endings are dead, interventional radiologists can perform osteoplasty. Osteoplasty involves the injection of semi-liquid bone cement (in this case, polymethyl-methacrylate or PMMA) into a bone lesion under constant and precise visual monitoring by CT or digital fluoroscopy imaging. The technique is similar to vertebroplasty, an interventional radiology treatment that has been used extensively in the spine to treat the pain of compression fractures.

In the study, the average pain intensity score for patients based on the 11-point visual analog scale dropped significantly from 8.8 +/1.4 to 1.8 +/2.1 within 24 hours of osteoplasty, said Anselmetti. "These patients experienced immediate and substantial pain relief. They did not require pain medication during the time of follow-up, and there were no clinically significant complications," said Anselmetti. Of 81 patients (59 women, 12 men), 64 (79 percent) were able to stop taking narcotic drugs for their pain, and 43 (53 percent) could stop taking other pain medication. In this study, pelvic, femur, sacrum, ribs, homerus, scapula, tibia, pubis and knee bones were treated.

In one case, Anselmetti recounted, a 79-year-old Roman Catholic nun had severe pain and was bedridden because of cancerous osteolytic lesions (thyroid cancer metastases) located deep in her pelvispreviously treated unsuccessfully with chemotherapy and radiotherapy. She underwent osteoplasty and experienced significant relief of pain and was able to walk two hours after the procedure. "This is the Lazarus effect," said Anselmetti, referring to the term often used to connote an apparent restoration to life, with Lazarus being the subject of the miracle recounted in the New Testament in which Jesus raises him from the dead. The nun, like other patients, was able to be discharged from the hospital on the same day.

"I cannot emphasize enough how important it is to provide relief to patients who are dying from their cancers. In most cases we can provide pain relief, restore function for them to do daily activities and help them to stay ambulatory," said Anselmetti. He noted that osteoplasty provided effective pain regression for individuals with both painful bone metastases and benign lytic lesions that didn't respond to conventional analgesic treatment.

Bones are the third most common location where cancer cells spread and metastasize. Bone metastases occur when cancer cells gain access to the blood stream, reach the bone marrow, begin to multiply and then grow new blood vessels to obtain oxygen and foodwhich in turn causes the cancer cells to grow more and spread. For the most part, the goal of treating bone tumors is not curative, but rather palliative by reducing pain, preventing additional bone destruction and improving function.


'/>"/>

Contact: Maryann Verrillo
mverrillo@SIRweb.org
703-460-5572
Society of Interventional Radiology
Source:Eurekalert

Related biology news :

1. $2.7 million awarded for metastatic colon cancer research
2. Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors
3. Metastatic movements in 3-D
4. Antioxidant overload may underlie a heritable human disease
5. Gender, coupled with diabetes, affects vascular disease development
6. Study links cat disease to flame retardants in furniture and to pet food
7. Humans fostering forest-destroying disease
8. Emerging (disease) markets
9. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
10. Clemson chemists discover new way antioxidants fight debilitating diseases
11. Finding that 1-in-a-billion that could lead to disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/23/2017)... PUNE, India , March 23, 2017 The report ... Equipment, Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by ... growing at a CAGR of 29.63% between 2017 and 2022. ... ... Logo ...
(Date:3/22/2017)... March 21, 2017   Neurotechnology , a ... technologies, today announced the release of the ... provides improved facial recognition using up to 10 ... single computer. The new version uses deep neural-network-based ... and it utilizes a Graphing Processing Unit (GPU) ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... MONTREAL , July 26th, 2017 /PRNewswire/ - Caprion Biosciences Inc., ... novel study identifying host blood proteins predictive of early stage ... spectrometry (MS) and multiple reaction monitoring (MRM-MS) platform. ... Caprion ... ...
(Date:7/26/2017)... ... July 25, 2017 , ... Proscia Inc. , a software ... a featured panelist at 2017 MedCity CONVERGE. His talk, “The Davids vs. the Cancer ... technology, and emerging technology (AI, VR, Big Data) sectors are taking aim at cancer ...
(Date:7/26/2017)... ... July 25, 2017 , ... In this ... better understanding of the considerations needed for designing ideal guide RNAs and DNA ... CRISPR-Cas9 to create targeted double-strand breaks in genomic DNA has greatly simplified strategies ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... problems we face every day. This unique capability combines high resolution imaging ... and manufacturers to deliver unprecedented datasets for chemical analysis, quality control, and decision-making. ...
Breaking Biology Technology: