Navigation Links
Metagenomics of skin reveals insights into the human microbiome

Friday, May 23, 2008 The human body is home to a diverse range of microorganisms, estimated to outnumber human cells in a healthy adult by ten fold. The importance of characterizing human microbiota for understanding health and disease is highlighted by the recent launch of the Human Microbiome Project by the National Institutes of Health. This report, published online today in Genome Research (, describes the investigation of healthy human skin for microbiota diversity and establishes the basis for determining a core microbiome.

The Human Microbiome Project aims to characterize the microbial communities of several regions of the body, including skin, where determining the core microbiome is essential to understanding and developing new treatments for skin conditions and diseases such as acne and atopic dermatitis (eczema). In this study, researchers led by Dr. Julie Segre of the National Human Genome Research Institute have generated a diversity profile of human skin microbiota by sequencing 16S rRNA, a component of the prokaryotic ribosome, isolated from a specific region of skin. We focused this study on the inner elbow to inform future clinical studies of the extremely common inflammatory skin disorder atopic dermatitis, which affects this area of the skin and is associated with Staphylococcus infections, explains Segre.

The researchers find that in the healthy subjects tested, Proteobacteria (predominantly Pseudomonas and Janthinobacterium) constituted the majority of inner elbow microbiota. Furthermore, this survey indicated that a common core skin microbiome exists between these individuals. Segre adds that this finding is critical for studying disease. Our long-term goal is to clarify the microbial contribution to a myriad of skin disorders both with known and suspected bacterial infections. Segres group also found that the microbiota of mouse skin is comparable to that of the human inner elbow, suggesting a potential model for human skin disorders related to microbiota.

Segre explains that this work has established a foundation for answering questions about microbiota and skin disease, with the potential for novel drugs and treatments. It's not surprising that microbes play a vital role in human health and disease, says Segre. Unfortunately the public is conditioned to view microbes antagonistically, when in fact they may hold the key to a whole new array of therapeutic options.


Contact: Peggy Calicchia
Cold Spring Harbor Laboratory

Related biology news :

1. Metagenomics of the deep Mediterranean
2. Metagenomics of the deep Mediterranean
3. A study reveals how cells communicate to activate the cell division machinery
4. Lean and mean biomass-degrading fungus reveals capabilities for improved biofuel production
5. First nanoscale image of soil reveals an incredible variety, rich with patterns
6. Power of molecular imaging reveals secrets of the heart
7. Isotope analysis reveals foraging area dichotomy for Atlantic leatherback turtles
8. Smithsonians National Museum of Natural History reveals ants as fungus farmers
9. Mantis shrimp vision reveals new way that animals can see
10. Research at Argonnes Advanced Photon Source reveals structure and behavior of collagen
11. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
Post Your Comments:
(Date:11/12/2015)... , Nov. 12, 2015  Arxspan has ... of MIT and Harvard for use of its ... information management tools. The partnership will support the ... biological and chemical research information internally and with ... be used for managing the Institute,s electronic laboratory ...
(Date:11/9/2015)... ) ... "Global Law Enforcement Biometrics Market 2015-2019" ... ) has announced the addition of ... 2015-2019" report to their offering. ... ) has announced the addition of the ...
(Date:10/29/2015)... 2015  The J. Craig Venter Institute (JCVI) policy ... and Biosecurity: Lessons Learned and Options for the Future," ... Human Services guidance for synthetic biology providers has worked ... --> --> Synthetic biology promises ... to pose unique biosecurity threats. It now is easier ...
Breaking Biology News(10 mins):
(Date:11/26/2015)... , England , November 26, 2015 ... Lightpoint Medical, an innovative medical device company specializing in imaging ... grant from the European Commission as part of the Horizon ... the company to carry out a large-scale clinical trial in ... -->      (Logo: , --> ...
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... a biotechnology company developing bioengineered organ implants for life-threatening ... will present at the LD Micro "Main Event" investor ... PT. The presentation will be webcast live and posted ... also be available at the conference for one-on-one meetings ...
(Date:11/25/2015)... 25, 2015 The Global ... a professional and in-depth study on the current ... (Logo: ) , The ... including definitions, classifications, applications and industry chain structure. ... international markets including development trends, competitive landscape analysis, ...
(Date:11/24/2015)... Therapeutics, Inc. (NASDAQ: HALO ) will be presenting at the ... on Wednesday, December 2 at 9:30 a.m. ET/6:30 a.m. PT . ... a corporate overview. th Annual Oppenheimer Healthcare Conference ... a.m. PT . Jim Mazzola , vice president of ... --> th Annual Oppenheimer Healthcare Conference in ...
Breaking Biology Technology: