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A new study has revealed that immature neurons taken from healthy mouse embryos can repair damaged brain circuitry and partially normalize metabolism when transplanted into adult mice that have grown morbidly obese due to a genetic deficiency. This proof-of-principle discovery represents one step down a long road toward neuronal replacement therapy, which researchers hope might one day be used to repair brains that have been injured by trauma or disease.
Artur Czupryn and colleagues took the immature neurons from the hypothalamus of wild-type mouse embryos and transplanted them into the hypothalamus of adult mice lacking a receptor for the hormone, leptin, which is known to regulate body weight. The researchers observed that the donor neurons were able to differentiate into four distinct neuronal types that then formed functional connections in the brains of the obese mice.
Their study appears in the 25 November 2011 issue of the journal Science, which is published by AAAS, the nonprofit science society.
"We chose this problem not because, even for a moment, we would pursue the idea of neuron transplantation for the treatment of obesity," explained Jeffrey Macklis from Harvard University, a corresponding author of the report. "What we did was take this very complicated circuitry in the hypothalamus that has a very clear, measurable outcomenot only obesity in the mice, but changes in their serum glucose (like diabetic human beings have), changes in their insulin levels and changes in their fat vs. lean body weightsand we used that complex circuitry as a test case for whether precisely selected and controlled neuron transplants could really rewire the brain."
The transplanted neurons did apparently restore leptin signaling in the brains of the obese mice because the rodents sl
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American Association for the Advancement of Science