Navigation Links
Metabolic defects in mice corrected with transplanted embryonic neurons
Date:11/24/2011

This release is available in Polish.

A new study has revealed that immature neurons taken from healthy mouse embryos can repair damaged brain circuitry and partially normalize metabolism when transplanted into adult mice that have grown morbidly obese due to a genetic deficiency. This proof-of-principle discovery represents one step down a long road toward neuronal replacement therapy, which researchers hope might one day be used to repair brains that have been injured by trauma or disease.

Artur Czupryn and colleagues took the immature neurons from the hypothalamus of wild-type mouse embryos and transplanted them into the hypothalamus of adult mice lacking a receptor for the hormone, leptin, which is known to regulate body weight. The researchers observed that the donor neurons were able to differentiate into four distinct neuronal types that then formed functional connections in the brains of the obese mice.

Their study appears in the 25 November 2011 issue of the journal Science, which is published by AAAS, the nonprofit science society.

"We chose this problem not because, even for a moment, we would pursue the idea of neuron transplantation for the treatment of obesity," explained Jeffrey Macklis from Harvard University, a corresponding author of the report. "What we did was take this very complicated circuitry in the hypothalamus that has a very clear, measurable outcomenot only obesity in the mice, but changes in their serum glucose (like diabetic human beings have), changes in their insulin levels and changes in their fat vs. lean body weightsand we used that complex circuitry as a test case for whether precisely selected and controlled neuron transplants could really rewire the brain."

The transplanted neurons did apparently restore leptin signaling in the brains of the obese mice because the rodents sl
'/>"/>

Contact: Natasha Pinol
npinol@aaas.org
202-326-7088
American Association for the Advancement of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. New inherited neurometabolic disorder discovered
2. Cell dysfunction linked to obesity and metabolic disorders
3. Cardiotrophin 1 shows promising results for treatment of obesity and metabolic syndrome
4. Metabolic state of brain cancer stem cells significantly different than the cancer cells they create
5. Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: U of A study
6. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
7. Metabolic syndrome increases risk of both major types of primary liver cancer
8. Key metabolic pathway implicated in intractable form of breast cancer
9. Hold your breath: Air pollution plays role in cardiac, metabolic diseases
10. Study shows pine bark naturally improves kidney function in patients with metabolic syndrome
11. Metabolic cost of human sleep deprivation quantified by University of Colorado team
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... of Utah biologist agan Sekercioglu, who campaigns to save ... highest science prize, which is similar to the U.S. ... researchers picked for 2014 the top awards by TUBITAK, ... researchers won the Science Award and two including ... to the Science Award but for scientists who are ...
(Date:8/27/2014)... what is described by the Volunteer Wildfire Services of ... Cape provincial government warned residents in certain parts of ... veld fires. A high veld fire danger rating ... coast in the Great Kei and Mnquma area. ... thunderstorms. The thunderstorms bring lightning strikes and subsequent ...
(Date:8/27/2014)... . , Charcot-Marie-Tooth ... affecting the peripheral nervous system. Researchers from the Department ... Medicine and University Medical Centre Gttingen have discovered that ... with the disease. These cells enwrap the nerve fibres ... the rapid transfer of electrical impulses. If Schwann cells ...
Breaking Biology News(10 mins):University of Utah biologist wins Turkey's top science prize 2Potential therapy for incurable Charcot-Marie-Tooth disease 2
... development and software company, has secured an exclusive ... deal has potential to enhance various forms of ... Proteomics is the scientific next step in vital ... founded in 2006 in Cleveland near Case Western ...
... In one of the most comprehensive studies of its kind, ... with the Harvard School of Global Health have found that people ... ischemic heart disease and tend to live longer than others. ... Colorado mountains helps reduce the risk of dying from heart ...
... ORLANDO, Fla. The American Association for Cancer Research ... Education Award for Undergraduate Students at the AACR 102nd Annual ... The primary purpose of the AACR-Thomas J. Bardos Science Education ... the undergraduate level to enter the field of cancer research. ...
Cached Biology News:Case Western Reserve and NeoProteomics announce exclusive option 2Study shows living at high altitude reduces risk of dying from heart disease 2AACR awards AACR-Thomas J. Bardos Science Education Award for Undergraduate Students 2AACR awards AACR-Thomas J. Bardos Science Education Award for Undergraduate Students 3
(Date:8/27/2014)... 2014 Remcom announces an update to ... features for the biomedical industry. The central biomedical ... Sensor, exclusive to the Bio-Pro version of the software. ... developed to calculate the biological effects of electromagnetic fields. ... to all versions to expand engineers’ post-processing options. , ...
(Date:8/27/2014)... Hunting Valley, Ohio (PRWEB) August 27, 2014 ... five students from Cleveland's University School ... at Case Western Reserve University’s School of ... program provides students with an unparalleled professional experience ... with the School of Medicine faculty and students ...
(Date:8/26/2014)...  NeuroSigma, Inc., a Los Angeles ... today announced that it has filed a registration statement ... Commission relating to a proposed initial public offering of ... offered and the price range for the proposed offering ... will act as the book-running manager for the proposed ...
(Date:8/26/2014)... , Aug. 26, 2014 An analysis ... structures of all Mers CoV virus strains ... structures back to 2012.  This conservation and sharing of ... a Synthetic Mers CoV Blocker-Vaccine™ candidate, as it did for ... vaccine, both of which have been found to be ...
Breaking Biology Technology:Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2
... 28 Neurotech Pharmaceuticals, Inc. today announced that the ... biologic effect in two Phase 2 clinical trials for ... developing condition that causes the progressive degeneration of rod ... time diminishes night and peripheral vision and eventually leads ...
... SpyGlass(R) Direct Visualization System can now be used ... NATICK, Mass., May 28 Boston Scientific Corporation ... it has received 510(k) clearance from the U.S. ... SpyScope(R) Access and Delivery Catheter for diagnostic and ...
... presenting at the Global Crop Protection Summit and exposition on 15-17th ... ... London, UK (PRWeb UK) - Pira International and ... Protection Summit in Edinburgh, Scotland on 15 - 17 September 2009. ...
Cached Biology Technology:Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors 2Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors 3Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors 4Results From Neurotech's NT-501 Phase 2 Retinitis Pigmentosa Studies Demonstrate Consistent Biological Effect on Photoreceptors 5FDA Clears Boston Scientific's SpyScope(R) Access and Delivery Catheter for Use in Endoscopic Procedures Throughout Pancreatico-Biliary System 2FDA Clears Boston Scientific's SpyScope(R) Access and Delivery Catheter for Use in Endoscopic Procedures Throughout Pancreatico-Biliary System 3FDA Clears Boston Scientific's SpyScope(R) Access and Delivery Catheter for Use in Endoscopic Procedures Throughout Pancreatico-Biliary System 4Call for papers for Pira International's Global Crop Protection Summit 2009 2
... Ham's F-12 was developed for culturing hybrid ... The modification consists of doubling the amino ... The salt concentrations have been altered as ... sulfate per liter, which may render it ...
... peptide whose sequence corresponds to residues 1-18 from rat rab 3D. ... M(1) - A - S - A - S - E ... R - D - A - A - D - Q ... and control experiments with the polyclonal antibody that reacts with this ...
... Bisulfite Kit enables complete conversion of ... than 6 hours. The highly sensitive ... DNA degradation and a spin-column-based purification ... and reliable results for all downstream ...
... or individual RNA sequences from high throughput synthesis ... RNAs from LC Sciences. These products provide a ... of DESIGNED sequences delivered in a microtube as ... a single verified RNA sequence. This is a ...
Biology Products: