Navigation Links
Metabolic defects in mice corrected with transplanted embryonic neurons
Date:11/24/2011

This release is available in Polish.

A new study has revealed that immature neurons taken from healthy mouse embryos can repair damaged brain circuitry and partially normalize metabolism when transplanted into adult mice that have grown morbidly obese due to a genetic deficiency. This proof-of-principle discovery represents one step down a long road toward neuronal replacement therapy, which researchers hope might one day be used to repair brains that have been injured by trauma or disease.

Artur Czupryn and colleagues took the immature neurons from the hypothalamus of wild-type mouse embryos and transplanted them into the hypothalamus of adult mice lacking a receptor for the hormone, leptin, which is known to regulate body weight. The researchers observed that the donor neurons were able to differentiate into four distinct neuronal types that then formed functional connections in the brains of the obese mice.

Their study appears in the 25 November 2011 issue of the journal Science, which is published by AAAS, the nonprofit science society.

"We chose this problem not because, even for a moment, we would pursue the idea of neuron transplantation for the treatment of obesity," explained Jeffrey Macklis from Harvard University, a corresponding author of the report. "What we did was take this very complicated circuitry in the hypothalamus that has a very clear, measurable outcomenot only obesity in the mice, but changes in their serum glucose (like diabetic human beings have), changes in their insulin levels and changes in their fat vs. lean body weightsand we used that complex circuitry as a test case for whether precisely selected and controlled neuron transplants could really rewire the brain."

The transplanted neurons did apparently restore leptin signaling in the brains of the obese mice because the rodents slimmed down and their metabolism began returning to normal levels, according to Czupryn and his colleagues.

"What we found is that these neurons not only turned into the right kinds of cells, but that they sent signals to the recipients' brain and received signals from the recipients' brain," said Macklis.

Although the researchers say that neuronal replacement is certainly not a practical approach to treating obesity, their study nonetheless provides evidence that the transplantation of donor neurons at the appropriate stage of development can promote functional recovery of a brain region that controls a complex phenotype.


'/>"/>

Contact: Natasha Pinol
npinol@aaas.org
202-326-7088
American Association for the Advancement of Science
Source:Eurekalert

Related biology news :

1. New inherited neurometabolic disorder discovered
2. Cell dysfunction linked to obesity and metabolic disorders
3. Cardiotrophin 1 shows promising results for treatment of obesity and metabolic syndrome
4. Metabolic state of brain cancer stem cells significantly different than the cancer cells they create
5. Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: U of A study
6. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
7. Metabolic syndrome increases risk of both major types of primary liver cancer
8. Key metabolic pathway implicated in intractable form of breast cancer
9. Hold your breath: Air pollution plays role in cardiac, metabolic diseases
10. Study shows pine bark naturally improves kidney function in patients with metabolic syndrome
11. Metabolic cost of human sleep deprivation quantified by University of Colorado team
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2016)... 23, 2016 ... Gesichts- und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler ... mit SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie ... die Möglichkeit angeboten, im Rahmen mobiler Apps ...
(Date:3/22/2016)... and SANDY, Utah , ... which operates the highest sample volume laboratory in ... Genomics and UNIConnect, leaders in clinical sequencing informatics and ... launch of a project to establish the informatics infrastructure ... NSO has been contracted by the Ontario ...
(Date:3/18/2016)... --> --> ... & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & Detection ... border security market and the continuing migration crisis in the ... has led visiongain to publish this unique report, ... defence & security companies in the border security ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of the ... brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing ... to its list of well-respected retailers. This list includes such fine stores as ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
Breaking Biology Technology: